Academic Journal
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile
| Τίτλος: | Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile |
|---|---|
| Συγγραφείς: | Merz, J., Nettesheim, A., von Garlen, S., Albrecht, P., Saller, B. S., Engelmann, J., Hertle, L., Schäfer, I., Dimanski, D., König, S., Karnbrock, L., Bulatova, K., Peikert, A., Hoppe, N., Hilgendorf, I., von zur Mühlen, C., Wolf, D., Groß, O., Bode, C., Zirlik, A., Stachon, Peter |
| Πηγή: | http://lobid.org/resources/99370675973806441#!, 17(3):481-492. |
| Έτος έκδοσης: | 2021 |
| Συλλογή: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| Θεματικοί όροι: | Transcriptome/physiology [MeSH], Macrophages, Inflammation Mediators/metabolism [MeSH], Macrophages/metabolism [MeSH], Animals [MeSH], Original Article, Mice [MeSH], Receptors, Purinergic/biosynthesis [MeSH], Purinergic/genetics [MeSH], Purinergic receptor: Inflammation, Cells, Cultured [MeSH], Cell Polarity/physiology [MeSH], Polarization |
| Περιγραφή: | Extracellular nucleotides act as danger signals that orchestrate inflammation by purinergic receptor activation. The expression pattern of different purinergic receptors may correlate with a pro- or anti-inflammatory phenotype. Macrophages function as pro-inflammatory M1 macrophages (M1) or anti-inflammatory M2 macrophages (M2). The present study found that murine bone marrow-derived macrophages express a unique purinergic receptor profile during in vitro polarization. As assessed by real-time polymerase chain reaction (PCR), Gαs-coupled P1 receptors A2A and A2B are upregulated in M1 and M2 compared to M0, but A2A 15 times higher in M1. The ionotropic P2 receptor P2X |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | https://repository.publisso.de/resource/frl:6444736; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410913/ |
| DOI: | 10.1007/s11302-021-09798-3 |
| Διαθεσιμότητα: | https://repository.publisso.de/resource/frl:6444736 https://doi.org/10.1007/s11302-021-09798-3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410913/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Αριθμός Καταχώρησης: | edsbas.6223405 |
| Βάση Δεδομένων: | BASE |
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