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Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial.

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Τίτλος: Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial.
Συγγραφείς: Knops, RE, van der Stuijt, W, Delnoy, PPHM, Boersma, LVA, Kuschyk, J, El-Chami, MF, Bonnemeier, H, Behr, ER, Brouwer, TF, Kääb, S, Mittal, S, Quast, A-FBE, Smeding, L, Tijssen, JGP, Bijsterveld, NR, Richter, S, Brouwer, MA, de Groot, JR, Kooiman, KM, Lambiase, PD, Neuzil, P, Vernooy, K, Alings, M, Betts, TR, Bracke, FALE, Burke, MC, de Jong, JSSG, Wright, DJ, Jansen, WPJ, Whinnet, ZI, Nordbeck, P, Knaut, M, Philbert, BT, van Opstal, JM, Chicos, AB, Allaart, CP, Borger van der Burg, AE, Clancy, JF, Dizon, JM, Miller, MA, Nemirovsky, D, Surber, R, Upadhyay, GA, Weiss, R, de Weger, A, Wilde, AAM, Olde Nordkamp, LRA, PRAETORIAN Investigators‡
Στοιχεία εκδότη: American Heart Association
Έτος έκδοσης: 2022
Συλλογή: St George's University of London: Repository
Περιγραφή: BACKGROUND: The PRAETORIAN trial (A Prospective, Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy) showed noninferiority of subcutaneous implantable cardioverter defibrillator (S-ICD) compared with transvenous implantable cardioverter defibrillator (TV-ICD) with regard to inappropriate shocks and complications. In contrast to TV-ICD, S-ICD cannot provide antitachycardia pacing for monomorphic ventricular tachycardia. This prespecified secondary analysis evaluates appropriate therapy and whether antitachycardia pacing reduces the number of appropriate shocks. METHODS: The PRAETORIAN trial was an international, investigator-initiated randomized trial that included patients with an indication for implantable cardioverter defibrillator (ICD) therapy. Patients with previous ventricular tachycardia <170 bpm or refractory recurrent monomorphic ventricular tachycardia were excluded. In 39 centers, 849 patients were randomized to receive an S-ICD (n=426) or TV-ICD (n=423) and were followed for a median of 49.1 months. ICD programming was mandated by protocol. Appropriate ICD therapy was defined as therapy for ventricular arrhythmias. Arrhythmias were classified as discrete episodes and storm episodes (≥3 episodes within 24 hours). Analyses were performed in the modified intention-to-treat population. RESULTS: In the S-ICD group, 86 of 426 patients received appropriate therapy, versus 78 of 423 patients in the TV-ICD group, during a median follow-up of 52 months (48-month Kaplan-Meier estimates 19.4% and 17.5%; P=0.45). In the S-ICD group, 83 patients received at least 1 shock, versus 57 patients in the TV-ICD group (48-month Kaplan-Meier estimates 19.2% and 11.5%; P=0.02). Patients in the S-ICD group had a total of 254 shocks, compared with 228 shocks in the TV-ICD group (P=0.68). First shock efficacy was 93.8% in the S-ICD group and 91.6% in the TV-ICD group (P=0.40). The first antitachycardia pacing attempt successfully terminated 46% of all monomorphic ventricular ...
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Γλώσσα: English
ISSN: 1524-4539
Relation: https://openaccess.sgul.ac.uk/id/eprint/113895/11/CIRCULATIONAHA.121.057816.pdf; https://openaccess.sgul.ac.uk/id/eprint/113895/6/10.1161circulationaha.121.057816_supplemental%20data.pdf; https://openaccess.sgul.ac.uk/id/eprint/113895/1/CIRCULATIONAHA.121.057816.pdf; Knops, RE; van der Stuijt, W; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; Kääb, S; et al. Knops, RE; van der Stuijt, W; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; Kääb, S; Mittal, S; Quast, A-FBE; Smeding, L; Tijssen, JGP; Bijsterveld, NR; Richter, S; Brouwer, MA; de Groot, JR; Kooiman, KM; Lambiase, PD; Neuzil, P; Vernooy, K; Alings, M; Betts, TR; Bracke, FALE; Burke, MC; de Jong, JSSG; Wright, DJ; Jansen, WPJ; Whinnet, ZI; Nordbeck, P; Knaut, M; Philbert, BT; van Opstal, JM; Chicos, AB; Allaart, CP; Borger van der Burg, AE; Clancy, JF; Dizon, JM; Miller, MA; Nemirovsky, D; Surber, R; Upadhyay, GA; Weiss, R; de Weger, A; Wilde, AAM; Olde Nordkamp, LRA; PRAETORIAN Investigators‡ (2022) Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial. Circulation, 145 (5). pp. 321-329. ISSN 1524-4539 https://doi.org/10.1161/CIRCULATIONAHA.121.057816 SGUL Authors: Behr, Elijah Raphael
DOI: 10.1161/CIRCULATIONAHA.121.057816
Διαθεσιμότητα: https://openaccess.sgul.ac.uk/id/eprint/113895/
https://openaccess.sgul.ac.uk/id/eprint/113895/11/CIRCULATIONAHA.121.057816.pdf
https://openaccess.sgul.ac.uk/id/eprint/113895/6/10.1161circulationaha.121.057816_supplemental%20data.pdf
https://openaccess.sgul.ac.uk/id/eprint/113895/1/CIRCULATIONAHA.121.057816.pdf
https://doi.org/10.1161/CIRCULATIONAHA.121.057816
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  Data: BACKGROUND: The PRAETORIAN trial (A Prospective, Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy) showed noninferiority of subcutaneous implantable cardioverter defibrillator (S-ICD) compared with transvenous implantable cardioverter defibrillator (TV-ICD) with regard to inappropriate shocks and complications. In contrast to TV-ICD, S-ICD cannot provide antitachycardia pacing for monomorphic ventricular tachycardia. This prespecified secondary analysis evaluates appropriate therapy and whether antitachycardia pacing reduces the number of appropriate shocks. METHODS: The PRAETORIAN trial was an international, investigator-initiated randomized trial that included patients with an indication for implantable cardioverter defibrillator (ICD) therapy. Patients with previous ventricular tachycardia &lt;170 bpm or refractory recurrent monomorphic ventricular tachycardia were excluded. In 39 centers, 849 patients were randomized to receive an S-ICD (n=426) or TV-ICD (n=423) and were followed for a median of 49.1 months. ICD programming was mandated by protocol. Appropriate ICD therapy was defined as therapy for ventricular arrhythmias. Arrhythmias were classified as discrete episodes and storm episodes (≥3 episodes within 24 hours). Analyses were performed in the modified intention-to-treat population. RESULTS: In the S-ICD group, 86 of 426 patients received appropriate therapy, versus 78 of 423 patients in the TV-ICD group, during a median follow-up of 52 months (48-month Kaplan-Meier estimates 19.4% and 17.5%; P=0.45). In the S-ICD group, 83 patients received at least 1 shock, versus 57 patients in the TV-ICD group (48-month Kaplan-Meier estimates 19.2% and 11.5%; P=0.02). Patients in the S-ICD group had a total of 254 shocks, compared with 228 shocks in the TV-ICD group (P=0.68). First shock efficacy was 93.8% in the S-ICD group and 91.6% in the TV-ICD group (P=0.40). The first antitachycardia pacing attempt successfully terminated 46% of all monomorphic ventricular ...
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  Data: https://openaccess.sgul.ac.uk/id/eprint/113895/11/CIRCULATIONAHA.121.057816.pdf; https://openaccess.sgul.ac.uk/id/eprint/113895/6/10.1161circulationaha.121.057816_supplemental%20data.pdf; https://openaccess.sgul.ac.uk/id/eprint/113895/1/CIRCULATIONAHA.121.057816.pdf; Knops, RE; van der Stuijt, W; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; K&#228;&#228;b, S; et al. Knops, RE; van der Stuijt, W; Delnoy, PPHM; Boersma, LVA; Kuschyk, J; El-Chami, MF; Bonnemeier, H; Behr, ER; Brouwer, TF; K&#228;&#228;b, S; Mittal, S; Quast, A-FBE; Smeding, L; Tijssen, JGP; Bijsterveld, NR; Richter, S; Brouwer, MA; de Groot, JR; Kooiman, KM; Lambiase, PD; Neuzil, P; Vernooy, K; Alings, M; Betts, TR; Bracke, FALE; Burke, MC; de Jong, JSSG; Wright, DJ; Jansen, WPJ; Whinnet, ZI; Nordbeck, P; Knaut, M; Philbert, BT; van Opstal, JM; Chicos, AB; Allaart, CP; Borger van der Burg, AE; Clancy, JF; Dizon, JM; Miller, MA; Nemirovsky, D; Surber, R; Upadhyay, GA; Weiss, R; de Weger, A; Wilde, AAM; Olde Nordkamp, LRA; PRAETORIAN Investigators‡ (2022) Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial. Circulation, 145 (5). pp. 321-329. ISSN 1524-4539 https://doi.org/10.1161/CIRCULATIONAHA.121.057816 SGUL Authors: Behr, Elijah Raphael
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            NameFull: Whinnet, ZI
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            NameFull: Chicos, AB
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      – PersonEntity:
          Name:
            NameFull: PRAETORIAN Investigators‡
    IsPartOfRelationships:
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 15244539
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
ResultId 1