Academic Journal
Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain.
| Τίτλος: | Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain. |
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| Συγγραφείς: | Nguyen-Duc, J., de Riedmatten, I., Spencer, APC, Perot, J.B., Olszowy, W., Jelescu, I. |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Θεματικοί όροι: | Humans, Male, Adult, Visual Pathways/diagnostic imaging, Visual Pathways/physiology, Female, Brain Mapping/methods, Magnetic Resonance Imaging/methods, Oxygen/blood, Young Adult, Brain/diagnostic imaging, Brain/physiology, Photic Stimulation/methods, Efferent Pathways/physiology, Efferent Pathways/diagnostic imaging, Diffusion Magnetic Resonance Imaging/methods, Image Processing, Computer-Assisted/methods, BOLD, apparent diffusion coefficient, diffusion MRI, fMRI, functional connectivity, visual cortex |
| Περιγραφή: | In contrast to blood-oxygenation level-dependent (BOLD) functional MRI (fMRI), which relies on changes in blood flow and oxygenation levels to infer brain activity, diffusion fMRI (DfMRI) investigates brain dynamics by monitoring alterations in the apparent diffusion coefficient (ADC) of water. These ADC changes may arise from fluctuations in neuronal morphology, providing a distinctive perspective on neural activity. The potential of ADC as an fMRI contrast (ADC-fMRI) lies in its capacity to reveal neural activity independently of neurovascular coupling, thus yielding complementary insights into brain function. To demonstrate the specificity and value of ADC-fMRI, both ADC- and BOLD-fMRI data were collected at 3 T in human subjects during visual stimulation and motor tasks. The first aim of this study was to identify an acquisition design for ADC that minimises BOLD contributions. By examining the timings in responses, we report that ADC 0/1 timeseries (acquired with b values of 0 and 1 ms/ ) exhibit residual vascular contamination, while ADC 0.2/1 timeseries (with b values of 0.2 and 1 ms/ ) show minimal BOLD influence and higher sensitivity to neuromorphological coupling. Second, a general linear model was employed to identify activation clusters for ADC 0.2/1 and BOLD, from which the average ADC and BOLD responses were calculated. The negative ADC response exhibited a significantly reduced delay relative to the task onset and offset as compared to BOLD. This early onset further supports the notion that ADC is sensitive to neuromorphological rather than neurovascular coupling. Remarkably, in the group-level analysis, positive BOLD activation clusters were detected in the visual and motor cortices, while the negative ADC clusters mainly highlighted pathways in white matter connected to the motor cortex. In the averaged individual level analysis, negative ADC activation clusters were also present in the visual cortex. This finding confirmed the reliability of negative ADC as an indicator of brain function, even ... |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1097-0193 |
| Relation: | Human Brain Mapping; https://iris.unil.ch/handle/iris/194726; serval:BIB_81668D5482EF; 001400631100001 |
| DOI: | 10.1002/hbm.70110 |
| Διαθεσιμότητα: | https://iris.unil.ch/handle/iris/194726 https://doi.org/10.1002/hbm.70110 |
| Αριθμός Καταχώρησης: | edsbas.5F4EC244 |
| Βάση Δεδομένων: | BASE |
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