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Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain.

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Τίτλος: Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain.
Συγγραφείς: Nguyen-Duc, J., de Riedmatten, I., Spencer, APC, Perot, J.B., Olszowy, W., Jelescu, I.
Έτος έκδοσης: 2025
Συλλογή: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
Θεματικοί όροι: Humans, Male, Adult, Visual Pathways/diagnostic imaging, Visual Pathways/physiology, Female, Brain Mapping/methods, Magnetic Resonance Imaging/methods, Oxygen/blood, Young Adult, Brain/diagnostic imaging, Brain/physiology, Photic Stimulation/methods, Efferent Pathways/physiology, Efferent Pathways/diagnostic imaging, Diffusion Magnetic Resonance Imaging/methods, Image Processing, Computer-Assisted/methods, BOLD, apparent diffusion coefficient, diffusion MRI, fMRI, functional connectivity, visual cortex
Περιγραφή: In contrast to blood-oxygenation level-dependent (BOLD) functional MRI (fMRI), which relies on changes in blood flow and oxygenation levels to infer brain activity, diffusion fMRI (DfMRI) investigates brain dynamics by monitoring alterations in the apparent diffusion coefficient (ADC) of water. These ADC changes may arise from fluctuations in neuronal morphology, providing a distinctive perspective on neural activity. The potential of ADC as an fMRI contrast (ADC-fMRI) lies in its capacity to reveal neural activity independently of neurovascular coupling, thus yielding complementary insights into brain function. To demonstrate the specificity and value of ADC-fMRI, both ADC- and BOLD-fMRI data were collected at 3 T in human subjects during visual stimulation and motor tasks. The first aim of this study was to identify an acquisition design for ADC that minimises BOLD contributions. By examining the timings in responses, we report that ADC 0/1 timeseries (acquired with b values of 0 and 1 ms/ ) exhibit residual vascular contamination, while ADC 0.2/1 timeseries (with b values of 0.2 and 1 ms/ ) show minimal BOLD influence and higher sensitivity to neuromorphological coupling. Second, a general linear model was employed to identify activation clusters for ADC 0.2/1 and BOLD, from which the average ADC and BOLD responses were calculated. The negative ADC response exhibited a significantly reduced delay relative to the task onset and offset as compared to BOLD. This early onset further supports the notion that ADC is sensitive to neuromorphological rather than neurovascular coupling. Remarkably, in the group-level analysis, positive BOLD activation clusters were detected in the visual and motor cortices, while the negative ADC clusters mainly highlighted pathways in white matter connected to the motor cortex. In the averaged individual level analysis, negative ADC activation clusters were also present in the visual cortex. This finding confirmed the reliability of negative ADC as an indicator of brain function, even ...
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
ISSN: 1097-0193
Relation: Human Brain Mapping; https://iris.unil.ch/handle/iris/194726; serval:BIB_81668D5482EF; 001400631100001
DOI: 10.1002/hbm.70110
Διαθεσιμότητα: https://iris.unil.ch/handle/iris/194726
https://doi.org/10.1002/hbm.70110
Αριθμός Καταχώρησης: edsbas.5F4EC244
Βάση Δεδομένων: BASE
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  Data: Mapping Activity and Functional Organisation of the Motor and Visual Pathways Using ADC-fMRI in the Human Brain.
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  Data: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
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  Data: In contrast to blood-oxygenation level-dependent (BOLD) functional MRI (fMRI), which relies on changes in blood flow and oxygenation levels to infer brain activity, diffusion fMRI (DfMRI) investigates brain dynamics by monitoring alterations in the apparent diffusion coefficient (ADC) of water. These ADC changes may arise from fluctuations in neuronal morphology, providing a distinctive perspective on neural activity. The potential of ADC as an fMRI contrast (ADC-fMRI) lies in its capacity to reveal neural activity independently of neurovascular coupling, thus yielding complementary insights into brain function. To demonstrate the specificity and value of ADC-fMRI, both ADC- and BOLD-fMRI data were collected at 3 T in human subjects during visual stimulation and motor tasks. The first aim of this study was to identify an acquisition design for ADC that minimises BOLD contributions. By examining the timings in responses, we report that ADC 0/1 timeseries (acquired with b values of 0 and 1 ms/ ) exhibit residual vascular contamination, while ADC 0.2/1 timeseries (with b values of 0.2 and 1 ms/ ) show minimal BOLD influence and higher sensitivity to neuromorphological coupling. Second, a general linear model was employed to identify activation clusters for ADC 0.2/1 and BOLD, from which the average ADC and BOLD responses were calculated. The negative ADC response exhibited a significantly reduced delay relative to the task onset and offset as compared to BOLD. This early onset further supports the notion that ADC is sensitive to neuromorphological rather than neurovascular coupling. Remarkably, in the group-level analysis, positive BOLD activation clusters were detected in the visual and motor cortices, while the negative ADC clusters mainly highlighted pathways in white matter connected to the motor cortex. In the averaged individual level analysis, negative ADC activation clusters were also present in the visual cortex. This finding confirmed the reliability of negative ADC as an indicator of brain function, even ...
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