Academic Journal
Studies on the endogenous compounds targeting to nucleic acids
| Τίτλος: | Studies on the endogenous compounds targeting to nucleic acids |
|---|---|
| Συγγραφείς: | Zhang, LH, Zhang, LR, Min, JM, Lin, GC |
| Συνεισφορές: | Zhang, LH (reprint author), Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China., Peking Univ, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China. |
| Πηγή: | SCI |
| Στοιχεία εκδότη: | 有机化学 |
| Έτος έκδοσης: | 2001 |
| Συλλογή: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| Θεματικοί όροι: | octyl-8-chloroadenosine 3 ',5 '-cyclophosphate, 8-Cl-adenosine, isonucleoside, oligonucleotide, BIOLOGICAL-ACTIVITIES, ISONUCLEOSIDES |
| Περιγραφή: | (Sp)-octyl-8-chloroadenosine 3',5'-cyclophosphate inhibited die growth of tumor cells by regulating cell signaling pathways. Its metabolic compound, 8-Cl-adenosine, also demonstrated the behaviors of inducing differentiation and initiating apoptosis in some tumor cells. Starting from D ( L)-xylose, D-glucose, or 2-amino-2-deoxy-D-glucose, five types of isonucleosides were synthesized. The oligonucleotides containing isonucleosides showed remarkable stability to the degradation by phosphodiesterase and their capacities of hybridizing complementary sequence depended on the structure of the isonucleosides and the linkage mode of the phosphodiester. ; Chemistry, Organic ; SCI(E) ; 中文核心期刊要目总览(PKU) ; 中国科学引文数据库(CSCD) ; 2 ; 11 ; 798-804 ; 21 |
| Τύπος εγγράφου: | journal/newspaper |
| Γλώσσα: | English |
| Relation: | 771805; https://hdl.handle.net/20.500.11897/389057; WOS:000173075900003 |
| Διαθεσιμότητα: | https://hdl.handle.net/20.500.11897/389057 |
| Αριθμός Καταχώρησης: | edsbas.5F1F15FE |
| Βάση Δεδομένων: | BASE |
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