Academic Journal
Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure
| Τίτλος: | Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure |
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| Συγγραφείς: | Zymlinski R., Sierpinski R., Metra M., Cotter G., Sokolski M., Siwolowski P., Garus M., Gajewski P., Tryba J., Samorek M., Jankowska E. A., Biegus J., Ponikowski P. |
| Συνεισφορές: | Zymlinski, R., Sierpinski, R., Metra, M., Cotter, G., Sokolski, M., Siwolowski, P., Garus, M., Gajewski, P., Tryba, J., Samorek, M., Jankowska, E. A., Biegus, J., Ponikowski, P. |
| Έτος έκδοσης: | 2020 |
| Θεματικοί όροι: | Congestion, Endothelin-1, Natriuresis, Renal function, Spot urine sodium |
| Περιγραφή: | Aims: Endothelin-1 (ET-1) is a potent vasoconstrictor, which regulates renal and vascular function. We aimed to relate plasma levels of ET-1 with the clinical picture and outcomes in acute heart failure (AHF). Methods and results: We studied 113 patients with AHF [mean age 65 ± 13 (years), median (upper and lower quartiles) N-terminal pro-B-type natriuretic peptide, 5422 (2689; 8582) (pg/mL)], in whom plasma levels of ET-1 were serially measured at admission (10.8 ± 5.2), Day 1 (9.5 ± 3.4), and Day 2 (8.9 ± 3.8) (pg/mL). The population was divided into tertiles across baseline ET-1 levels. Patients in the highest ET-1 tertile had predominant clinical signs of peripheral congestion; however, no difference was observed in pulmonary congestion and severity of dyspnoea. They also presented lower spot urine sodium at admission (75 ± 35 vs. 99 ± 43 vs. 108 ± 30), 6 h (84 ± 34 vs. 106 ± 43 vs. 106 ± 35), and Day 1 (75 ± 38 vs. 96 ± 36 vs. 100 ± 35) (mmol/L), when compared with the second and first tertile, respectively (all P < 0.05); furthermore, they received higher doses of intravenous furosemide from Day 2 and had longer intravenous diuretics, as median switch to oral furosemide was 4 (3; 4) vs. 3 (2; 4) vs. 2 (2; 3) (days), respectively, P < 0.05. There was no difference in serum creatinine, urea, and renal injury biomarkers (kidney injury molecule-1, serum cystatin C, and urine neutrophil gelatinase-associated lipocalin) between the ET-1 tertiles. Higher values of ET-1 measured at each time point were related with a higher risk of 1 year mortality. Conclusions: Elevation of ET-1 is related to clinical signs of peripheral congestion, low urine sodium excretion, and poor outcome in AHF. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33063475; info:eu-repo/semantics/altIdentifier/wos/WOS:000578233700001; volume:7; issue:6; firstpage:3536; lastpage:3544; numberofpages:9; journal:ESC HEART FAILURE; https://hdl.handle.net/20.500.11768/193901 |
| DOI: | 10.1002/ehf2.13064 |
| Διαθεσιμότητα: | https://hdl.handle.net/20.500.11768/193901 https://doi.org/10.1002/ehf2.13064 |
| Αριθμός Καταχώρησης: | edsbas.5CD9DAB7 |
| Βάση Δεδομένων: | BASE |
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