Academic Journal
Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure
| Τίτλος: | Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure |
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| Συγγραφείς: | Zymlinski R., Sierpinski R., Metra M., Cotter G., Sokolski M., Siwolowski P., Garus M., Gajewski P., Tryba J., Samorek M., Jankowska E. A., Biegus J., Ponikowski P. |
| Συνεισφορές: | Zymlinski, R., Sierpinski, R., Metra, M., Cotter, G., Sokolski, M., Siwolowski, P., Garus, M., Gajewski, P., Tryba, J., Samorek, M., Jankowska, E. A., Biegus, J., Ponikowski, P. |
| Έτος έκδοσης: | 2020 |
| Θεματικοί όροι: | Congestion, Endothelin-1, Natriuresis, Renal function, Spot urine sodium |
| Περιγραφή: | Aims: Endothelin-1 (ET-1) is a potent vasoconstrictor, which regulates renal and vascular function. We aimed to relate plasma levels of ET-1 with the clinical picture and outcomes in acute heart failure (AHF). Methods and results: We studied 113 patients with AHF [mean age 65 ± 13 (years), median (upper and lower quartiles) N-terminal pro-B-type natriuretic peptide, 5422 (2689; 8582) (pg/mL)], in whom plasma levels of ET-1 were serially measured at admission (10.8 ± 5.2), Day 1 (9.5 ± 3.4), and Day 2 (8.9 ± 3.8) (pg/mL). The population was divided into tertiles across baseline ET-1 levels. Patients in the highest ET-1 tertile had predominant clinical signs of peripheral congestion; however, no difference was observed in pulmonary congestion and severity of dyspnoea. They also presented lower spot urine sodium at admission (75 ± 35 vs. 99 ± 43 vs. 108 ± 30), 6 h (84 ± 34 vs. 106 ± 43 vs. 106 ± 35), and Day 1 (75 ± 38 vs. 96 ± 36 vs. 100 ± 35) (mmol/L), when compared with the second and first tertile, respectively (all P < 0.05); furthermore, they received higher doses of intravenous furosemide from Day 2 and had longer intravenous diuretics, as median switch to oral furosemide was 4 (3; 4) vs. 3 (2; 4) vs. 2 (2; 3) (days), respectively, P < 0.05. There was no difference in serum creatinine, urea, and renal injury biomarkers (kidney injury molecule-1, serum cystatin C, and urine neutrophil gelatinase-associated lipocalin) between the ET-1 tertiles. Higher values of ET-1 measured at each time point were related with a higher risk of 1 year mortality. Conclusions: Elevation of ET-1 is related to clinical signs of peripheral congestion, low urine sodium excretion, and poor outcome in AHF. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33063475; info:eu-repo/semantics/altIdentifier/wos/WOS:000578233700001; volume:7; issue:6; firstpage:3536; lastpage:3544; numberofpages:9; journal:ESC HEART FAILURE; https://hdl.handle.net/20.500.11768/193901 |
| DOI: | 10.1002/ehf2.13064 |
| Διαθεσιμότητα: | https://hdl.handle.net/20.500.11768/193901 https://doi.org/10.1002/ehf2.13064 |
| Αριθμός Καταχώρησης: | edsbas.5CD9DAB7 |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://hdl.handle.net/20.500.11768/193901# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
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| Header | DbId: edsbas DbLabel: BASE An: edsbas.5CD9DAB7 RelevancyScore: 824 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 823.994323730469 |
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| Items | – Name: Title Label: Title Group: Ti Data: Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zymlinski+R%2E%22">Zymlinski R.</searchLink><br /><searchLink fieldCode="AR" term="%22Sierpinski+R%2E%22">Sierpinski R.</searchLink><br /><searchLink fieldCode="AR" term="%22Metra+M%2E%22">Metra M.</searchLink><br /><searchLink fieldCode="AR" term="%22Cotter+G%2E%22">Cotter G.</searchLink><br /><searchLink fieldCode="AR" term="%22Sokolski+M%2E%22">Sokolski M.</searchLink><br /><searchLink fieldCode="AR" term="%22Siwolowski+P%2E%22">Siwolowski P.</searchLink><br /><searchLink fieldCode="AR" term="%22Garus+M%2E%22">Garus M.</searchLink><br /><searchLink fieldCode="AR" term="%22Gajewski+P%2E%22">Gajewski P.</searchLink><br /><searchLink fieldCode="AR" term="%22Tryba+J%2E%22">Tryba J.</searchLink><br /><searchLink fieldCode="AR" term="%22Samorek+M%2E%22">Samorek M.</searchLink><br /><searchLink fieldCode="AR" term="%22Jankowska+E%2E+A%2E%22">Jankowska E. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Biegus+J%2E%22">Biegus J.</searchLink><br /><searchLink fieldCode="AR" term="%22Ponikowski+P%2E%22">Ponikowski P.</searchLink> – Name: Author Label: Contributors Group: Au Data: Zymlinski, R.<br />Sierpinski, R.<br />Metra, M.<br />Cotter, G.<br />Sokolski, M.<br />Siwolowski, P.<br />Garus, M.<br />Gajewski, P.<br />Tryba, J.<br />Samorek, M.<br />Jankowska, E. A.<br />Biegus, J.<br />Ponikowski, P. – Name: DatePubCY Label: Publication Year Group: Date Data: 2020 – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Congestion%22">Congestion</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelin-1%22">Endothelin-1</searchLink><br /><searchLink fieldCode="DE" term="%22Natriuresis%22">Natriuresis</searchLink><br /><searchLink fieldCode="DE" term="%22Renal+function%22">Renal function</searchLink><br /><searchLink fieldCode="DE" term="%22Spot+urine+sodium%22">Spot urine sodium</searchLink> – Name: Abstract Label: Description Group: Ab Data: Aims: Endothelin-1 (ET-1) is a potent vasoconstrictor, which regulates renal and vascular function. We aimed to relate plasma levels of ET-1 with the clinical picture and outcomes in acute heart failure (AHF). Methods and results: We studied 113 patients with AHF [mean age 65 ± 13 (years), median (upper and lower quartiles) N-terminal pro-B-type natriuretic peptide, 5422 (2689; 8582) (pg/mL)], in whom plasma levels of ET-1 were serially measured at admission (10.8 ± 5.2), Day 1 (9.5 ± 3.4), and Day 2 (8.9 ± 3.8) (pg/mL). The population was divided into tertiles across baseline ET-1 levels. Patients in the highest ET-1 tertile had predominant clinical signs of peripheral congestion; however, no difference was observed in pulmonary congestion and severity of dyspnoea. They also presented lower spot urine sodium at admission (75 ± 35 vs. 99 ± 43 vs. 108 ± 30), 6 h (84 ± 34 vs. 106 ± 43 vs. 106 ± 35), and Day 1 (75 ± 38 vs. 96 ± 36 vs. 100 ± 35) (mmol/L), when compared with the second and first tertile, respectively (all P < 0.05); furthermore, they received higher doses of intravenous furosemide from Day 2 and had longer intravenous diuretics, as median switch to oral furosemide was 4 (3; 4) vs. 3 (2; 4) vs. 2 (2; 3) (days), respectively, P < 0.05. There was no difference in serum creatinine, urea, and renal injury biomarkers (kidney injury molecule-1, serum cystatin C, and urine neutrophil gelatinase-associated lipocalin) between the ET-1 tertiles. Higher values of ET-1 measured at each time point were related with a higher risk of 1 year mortality. Conclusions: Elevation of ET-1 is related to clinical signs of peripheral congestion, low urine sodium excretion, and poor outcome in AHF. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Language Label: Language Group: Lang Data: English – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: info:eu-repo/semantics/altIdentifier/pmid/33063475; info:eu-repo/semantics/altIdentifier/wos/WOS:000578233700001; volume:7; issue:6; firstpage:3536; lastpage:3544; numberofpages:9; journal:ESC HEART FAILURE; https://hdl.handle.net/20.500.11768/193901 – Name: DOI Label: DOI Group: ID Data: 10.1002/ehf2.13064 – Name: URL Label: Availability Group: URL Data: https://hdl.handle.net/20.500.11768/193901<br />https://doi.org/10.1002/ehf2.13064 – Name: AN Label: Accession Number Group: ID Data: edsbas.5CD9DAB7 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.5CD9DAB7 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/ehf2.13064 Languages: – Text: English Subjects: – SubjectFull: Congestion Type: general – SubjectFull: Endothelin-1 Type: general – SubjectFull: Natriuresis Type: general – SubjectFull: Renal function Type: general – SubjectFull: Spot urine sodium Type: general Titles: – TitleFull: Elevated plasma endothelin-1 is related to low natriuresis, clinical signs of congestion, and poor outcome in acute heart failure Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zymlinski R. – PersonEntity: Name: NameFull: Sierpinski R. – PersonEntity: Name: NameFull: Metra M. – PersonEntity: Name: NameFull: Cotter G. – PersonEntity: Name: NameFull: Sokolski M. – PersonEntity: Name: NameFull: Siwolowski P. – PersonEntity: Name: NameFull: Garus M. – PersonEntity: Name: NameFull: Gajewski P. – PersonEntity: Name: NameFull: Tryba J. – PersonEntity: Name: NameFull: Samorek M. – PersonEntity: Name: NameFull: Jankowska E. A. – PersonEntity: Name: NameFull: Biegus J. – PersonEntity: Name: NameFull: Ponikowski P. – PersonEntity: Name: NameFull: Zymlinski, R. – PersonEntity: Name: NameFull: Sierpinski, R. – PersonEntity: Name: NameFull: Metra, M. – PersonEntity: Name: NameFull: Cotter, G. – PersonEntity: Name: NameFull: Sokolski, M. – PersonEntity: Name: NameFull: Siwolowski, P. – PersonEntity: Name: NameFull: Garus, M. – PersonEntity: Name: NameFull: Gajewski, P. – PersonEntity: Name: NameFull: Tryba, J. – PersonEntity: Name: NameFull: Samorek, M. – PersonEntity: Name: NameFull: Jankowska, E. A. – PersonEntity: Name: NameFull: Biegus, J. – PersonEntity: Name: NameFull: Ponikowski, P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2020 Identifiers: – Type: issn-locals Value: edsbas |
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