Loss of Upk1a and Upk1b expression is linked to stage progression in urothelial carcinoma of the bladder

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Loss of Upk1a and Upk1b expression is linked to stage progression in urothelial carcinoma of the bladder
Συγγραφείς:	Kaczmarek, Krystian, Plage, Henning, Furlano, Kira, Hofbauer, Sebastian, Weinberger, Sarah, Ralla, Bernhard, Franz, Antonia, Fendler, Annika, de Martino, Michela, Roßner, Florian, Schallenberg, Simon, Elezkurtaj, Sefer, Kluth, Martina, Lennartz, Maximilian, Blessin, Niclas C., Marx, Andreas H., Samtleben, Henrik, Fisch, Margit, Rink, Michael, Slojewski, Marcin, Ecke, Thorsten, Hallmann, Steffen, Koch, Stefan, Adamini, Nico, Minner, Sarah, Simon, Ronald, Sauter, Guido, Weischenfeldt, Joachim, Klatte, Tobias, Schlomm, Thorsten, Horst, David, Zecha, Henrik
Πηγή:	http://lobid.org/resources/99370672450506441#!, 56(2):499-508.
Έτος έκδοσης:	2023
Συλλογή:	Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Θεματικοί όροι:	Upk1a, Urinary Bladder/pathology [MeSH], Urothelial carcinoma, Immunohistochemistry, Upk1b, Humans [MeSH], Diagnostic marker, Uroplakin Ib/metabolism [MeSH], Urinary Bladder Neoplasms/pathology [MeSH], Tissue microarray, Carcinoma, Transitional Cell/pathology [MeSH], Biomarkers, Tumor/metabolism [MeSH], Uroplakin Ia/metabolism [MeSH], Urology - Original Paper
Περιγραφή:	Abstract Background Uroplakin-1a (Upk1a) and uroplakin-1b (Upk1b) have recently been identified as diagnostic markers for the distinction of urothelial carcinomas from other solid tumor entities. Both proteins play an important role in the stabilization and strengthening of epithelial cells that line the bladder. Methods To evaluate the prognostic role of uroplakin expression in urothelial carcinomas, more than 2700 urothelial neoplasms were analyzed in a tissue microarray format by immunohistochemistry. To further assess the diagnostic role of uroplakin immunohistochemistry, results were compared with preexisting GATA3 data. Result The fraction of Upk1a/Upk1b positive cases decreased slightly from pTaG2 low-grade (88% positive for Upk1a/87% positive for Upk1b) and pTaG2 high-grade (92%/89%) to pTaG3 (83%/88%; p > 0.05) and was lower in muscle-invasive (pT2-4) carcinomas (42%/64%; p < 0.0001/p < 0.0001 for pTa vs. pT2-4). Within pT2-4 carcinomas, high expression of Upk1a and Upk1b was linked to nodal metastasis and lymphatic vessel infiltration (p < 0.05) but unrelated to patient outcome. There were significant associations between Upk1a, Upk1b and GATA3 immunostaining (p < 0.0001 each), but 11% of GATA3 negative cancers were Upk1a/b positive and 8% of Upk1a/b negative cancers were GATA3 positive. Absence of GATA3/Upk1a/b staining was significantly linked to poor patient survival in the subgroup of 126 pT4 carcinomas (p = 0.0004) but not in pT2 and pT3 ...
Τύπος εγγράφου:	article in journal/newspaper
Γλώσσα:	English
Relation:	https://repository.publisso.de/resource/frl:6500065; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808463/
DOI:	10.1007/s11255-023-03800-0
Διαθεσιμότητα:	https://repository.publisso.de/resource/frl:6500065 https://doi.org/10.1007/s11255-023-03800-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808463/
Rights:	https://creativecommons.org/licenses/by/4.0/
Αριθμός Καταχώρησης:	edsbas.56AD654D
Βάση Δεδομένων:	BASE

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