Academic Journal
근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구 ; Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth
| Τίτλος: | 근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구 ; Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth |
|---|---|
| Συνεισφορές: | Shin, Su Jung |
| Πηγή: | T201103906.pdf |
| Έτος έκδοσης: | 2011 |
| Θεματικοί όροι: | Adult, Female, Follow-Up Studies, Gingival Crevicular Fluid/chemistry, Humans, Inflammation Mediators/analysis, Male, Matrix Metalloproteinase 8/analysis, Neurotransmitter Agents/analysis, Pain Measurement, Periapical Periodontitis/metabolism, Prospective Studies, Root Canal Irrigants/therapeutic use, Root Canal Obturation/methods, Root Canal Preparation/instrumentation, Root Canal Therapy, Sodium Hypochlorite/therapeutic use, Substance P/analysis, Tooth, Nonvital/metabolism, Nonvital/therapy, Toothache/metabolism |
| Περιγραφή: | OBJECTIVES: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth. MATERIALS AND METHODS: Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05). RESULTS: MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level. CONCLUSIONS: This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis ; open |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | 196~202 |
| Γλώσσα: | unknown |
| Relation: | Journal of Korean Academy of Operative Dentistry (대한치과보존학회지); J01488; https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545; T201103906; 27404 |
| DOI: | 10.5395/JKACD.2011.36.3.196 |
| Διαθεσιμότητα: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545 https://doi.org/10.5395/JKACD.2011.36.3.196 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; free |
| Αριθμός Καταχώρησης: | edsbas.55361E3D |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
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| Header | DbId: edsbas DbLabel: BASE An: edsbas.55361E3D RelevancyScore: 843 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 842.654235839844 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: 근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구 ; Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth – Name: Author Label: Contributors Group: Au Data: Shin, Su Jung – Name: TitleSource Label: Source Group: Src Data: T201103906.pdf – Name: DatePubCY Label: Publication Year Group: Date Data: 2011 – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Follow-Up+Studies%22">Follow-Up Studies</searchLink><br /><searchLink fieldCode="DE" term="%22Gingival+Crevicular+Fluid%2Fchemistry%22">Gingival Crevicular Fluid/chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation+Mediators%2Fanalysis%22">Inflammation Mediators/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Matrix+Metalloproteinase+8%2Fanalysis%22">Matrix Metalloproteinase 8/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitter+Agents%2Fanalysis%22">Neurotransmitter Agents/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Pain+Measurement%22">Pain Measurement</searchLink><br /><searchLink fieldCode="DE" term="%22Periapical+Periodontitis%2Fmetabolism%22">Periapical Periodontitis/metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Prospective+Studies%22">Prospective Studies</searchLink><br /><searchLink fieldCode="DE" term="%22Root+Canal+Irrigants%2Ftherapeutic+use%22">Root Canal Irrigants/therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Root+Canal+Obturation%2Fmethods%22">Root Canal Obturation/methods</searchLink><br /><searchLink fieldCode="DE" term="%22Root+Canal+Preparation%2Finstrumentation%22">Root Canal Preparation/instrumentation</searchLink><br /><searchLink fieldCode="DE" term="%22Root+Canal+Therapy%22">Root Canal Therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Sodium+Hypochlorite%2Ftherapeutic+use%22">Sodium Hypochlorite/therapeutic use</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+P%2Fanalysis%22">Substance P/analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Tooth%22">Tooth</searchLink><br /><searchLink fieldCode="DE" term="%22Nonvital%2Fmetabolism%22">Nonvital/metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Nonvital%2Ftherapy%22">Nonvital/therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Toothache%2Fmetabolism%22">Toothache/metabolism</searchLink> – Name: Abstract Label: Description Group: Ab Data: OBJECTIVES: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth. MATERIALS AND METHODS: Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05). RESULTS: MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level. CONCLUSIONS: This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis ; open – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: 196~202 – Name: Language Label: Language Group: Lang Data: unknown – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: Journal of Korean Academy of Operative Dentistry (대한치과보존학회지); J01488; https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545; T201103906; 27404 – Name: DOI Label: DOI Group: ID Data: 10.5395/JKACD.2011.36.3.196 – Name: URL Label: Availability Group: URL Data: https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545<br />https://doi.org/10.5395/JKACD.2011.36.3.196 – Name: Copyright Label: Rights Group: Cpyrght Data: CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; free – Name: AN Label: Accession Number Group: ID Data: edsbas.55361E3D |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.55361E3D |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.5395/JKACD.2011.36.3.196 Languages: – Text: unknown Subjects: – SubjectFull: Adult Type: general – SubjectFull: Female Type: general – SubjectFull: Follow-Up Studies Type: general – SubjectFull: Gingival Crevicular Fluid/chemistry Type: general – SubjectFull: Humans Type: general – SubjectFull: Inflammation Mediators/analysis Type: general – SubjectFull: Male Type: general – SubjectFull: Matrix Metalloproteinase 8/analysis Type: general – SubjectFull: Neurotransmitter Agents/analysis Type: general – SubjectFull: Pain Measurement Type: general – SubjectFull: Periapical Periodontitis/metabolism Type: general – SubjectFull: Prospective Studies Type: general – SubjectFull: Root Canal Irrigants/therapeutic use Type: general – SubjectFull: Root Canal Obturation/methods Type: general – SubjectFull: Root Canal Preparation/instrumentation Type: general – SubjectFull: Root Canal Therapy Type: general – SubjectFull: Sodium Hypochlorite/therapeutic use Type: general – SubjectFull: Substance P/analysis Type: general – SubjectFull: Tooth Type: general – SubjectFull: Nonvital/metabolism Type: general – SubjectFull: Nonvital/therapy Type: general – SubjectFull: Toothache/metabolism Type: general Titles: – TitleFull: 근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구 ; Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shin, Su Jung IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2011 Identifiers: – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa Titles: – TitleFull: T201103906.pdf Type: main |
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