Academic Journal
근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구 ; Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth
| Τίτλος: | 근관 삼출액에서의 기질금속단백분해효소-8과 substance P의 수준에 관한 연구 ; Matrix metalloproteinase-8 and substance P levels in root canal exudates of nonvital teeth |
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| Συνεισφορές: | Shin, Su Jung |
| Πηγή: | T201103906.pdf |
| Έτος έκδοσης: | 2011 |
| Θεματικοί όροι: | Adult, Female, Follow-Up Studies, Gingival Crevicular Fluid/chemistry, Humans, Inflammation Mediators/analysis, Male, Matrix Metalloproteinase 8/analysis, Neurotransmitter Agents/analysis, Pain Measurement, Periapical Periodontitis/metabolism, Prospective Studies, Root Canal Irrigants/therapeutic use, Root Canal Obturation/methods, Root Canal Preparation/instrumentation, Root Canal Therapy, Sodium Hypochlorite/therapeutic use, Substance P/analysis, Tooth, Nonvital/metabolism, Nonvital/therapy, Toothache/metabolism |
| Περιγραφή: | OBJECTIVES: The aim of this study was to investigate levels of matrix metalloproteinase-8 (MMP-8) and substance P (SP) in root canal exudates during root canal treatment (RCT) of nonvital, painful teeth. MATERIALS AND METHODS: Patients scheduled for nonsurgical RCT were prospectively selected; the study was performed after obtaining informed consent from the patients and was approved by the Institutional Review Board for Clinical Research of Gangnam Severance Hospital, Yonsei University (3-2008-0118). Canal exudates samples were collected using sterilized paper points from teeth scheduled for RCT across three different time periods. MMP-8 and SP levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed using a mixed model analysis and the Pearson correlation analysis (p < 0.05). RESULTS: MMP-8 and SP levels in GCF were decreased during RCT (p < 0.0001), and they showed a weak positive correlation to each other (p < 0.05). Patients'subjective pain levels and the response from percussion test were significantly related to SP level. CONCLUSIONS: This study demonstrated that periradicular inflammation endodontic origin can elevate SP and MMP-8 levels in root canal exudates. Interestingly, SP level of canal exudates showed a possibility of being used as an indicator of pain due to periapical pathosis ; open |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | 196~202 |
| Γλώσσα: | unknown |
| Relation: | Journal of Korean Academy of Operative Dentistry (대한치과보존학회지); J01488; https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545; T201103906; 27404 |
| DOI: | 10.5395/JKACD.2011.36.3.196 |
| Διαθεσιμότητα: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94545 https://doi.org/10.5395/JKACD.2011.36.3.196 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; free |
| Αριθμός Καταχώρησης: | edsbas.55361E3D |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.5395/JKACD.2011.36.3.196 |
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