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Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues

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Title: Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues
Authors: Brunner, Martin, Hollenstein, Ursula, Delacher, Simon, Jäger, Dorothea, Schmid, Rainer, Lackner, Edith, Georgopoulos, Apostoulos, Eichler, Hans Georg, Müller, Markus
Source: Antimicrobial Agents and Chemotherapy ; volume 43, issue 5, page 1307-1309 ; ISSN 0066-4804 1098-6596
Publisher Information: American Society for Microbiology
Publication Year: 1999
Description: Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.
Document Type: article in journal/newspaper
Language: English
DOI: 10.1128/aac.43.5.1307
DOI: 10.1128/AAC.43.5.1307
Availability: https://doi.org/10.1128/aac.43.5.1307
https://journals.asm.org/doi/pdf/10.1128/AAC.43.5.1307
Rights: https://journals.asm.org/non-commercial-tdm-license
Accession Number: edsbas.54D2CDAF
Database: BASE
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  – Url: https://doi.org/10.1128/aac.43.5.1307#
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  Data: <searchLink fieldCode="AR" term="%22Brunner%2C+Martin%22">Brunner, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Hollenstein%2C+Ursula%22">Hollenstein, Ursula</searchLink><br /><searchLink fieldCode="AR" term="%22Delacher%2C+Simon%22">Delacher, Simon</searchLink><br /><searchLink fieldCode="AR" term="%22Jäger%2C+Dorothea%22">Jäger, Dorothea</searchLink><br /><searchLink fieldCode="AR" term="%22Schmid%2C+Rainer%22">Schmid, Rainer</searchLink><br /><searchLink fieldCode="AR" term="%22Lackner%2C+Edith%22">Lackner, Edith</searchLink><br /><searchLink fieldCode="AR" term="%22Georgopoulos%2C+Apostoulos%22">Georgopoulos, Apostoulos</searchLink><br /><searchLink fieldCode="AR" term="%22Eichler%2C+Hans+Georg%22">Eichler, Hans Georg</searchLink><br /><searchLink fieldCode="AR" term="%22Müller%2C+Markus%22">Müller, Markus</searchLink>
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  Data: Antimicrobial Agents and Chemotherapy ; volume 43, issue 5, page 1307-1309 ; ISSN 0066-4804 1098-6596
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  Data: 1999
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  Data: Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.
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