Academic Journal
Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues
| Τίτλος: | Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues |
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| Συγγραφείς: | Brunner, Martin, Hollenstein, Ursula, Delacher, Simon, Jäger, Dorothea, Schmid, Rainer, Lackner, Edith, Georgopoulos, Apostoulos, Eichler, Hans Georg, Müller, Markus |
| Πηγή: | Antimicrobial Agents and Chemotherapy ; volume 43, issue 5, page 1307-1309 ; ISSN 0066-4804 1098-6596 |
| Στοιχεία εκδότη: | American Society for Microbiology |
| Έτος έκδοσης: | 1999 |
| Περιγραφή: | Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.1128/aac.43.5.1307 |
| DOI: | 10.1128/AAC.43.5.1307 |
| Διαθεσιμότητα: | https://doi.org/10.1128/aac.43.5.1307 https://journals.asm.org/doi/pdf/10.1128/AAC.43.5.1307 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| Αριθμός Καταχώρησης: | edsbas.54D2CDAF |
| Βάση Δεδομένων: | BASE |
| DOI: | 10.1128/aac.43.5.1307 |
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