Academic Journal
Predictors of poststroke aphasia recovery: a systematic review-informed individual participant data meta-analysis
| Title: | Predictors of poststroke aphasia recovery: a systematic review-informed individual participant data meta-analysis |
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| Authors: | Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Pietro-Bachmann, Marie di, Enderby, Pamela, Fillingham, Joanne, Lucia Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Charlotte Laska, Ann, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcus, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F, Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Harris Wright, Heather, Brady, Marian C. |
| Contributors: | Ali, Myzoon, Vandenberg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank, Bowen, Audrey, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie, Copland, David A., Cranfill, Tamara B., Pietro-Bachmann, Marie di, Enderby, Pamela, Fillingham, Joanne, Lucia Galli, Federica, Gandolfi, Marialuisa, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kyoung Kang, Eun, Khedr, Eman M., Pak-Hin Kong, Anthony, Kukkonen, Tarja, Laganaro, Marina, Lambon Ralph, Matthew A., Charlotte Laska, Ann, Leemann, Béatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Shisler Marshall, Rebecca, Mattioli, Flavia, Maviş, İlknur, Meinzer, Marcu, Nilipour, Reza, Noé, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilia, Patricio, Brigida F, Pavão Martins, Isabel, Price, Cathy, Prizl Jakovac, Tatjana, Rochon, Elizabeth, Rose, Miranda L, Rosso, Charlotte, Rubi-Fessen, Ilona, Ruiter, Marina B., Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., van de Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Harris Wright, Heather, Brady, Marian C. |
| Publication Year: | 2021 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: | aphasia, comprehension, demography, language, survivor |
| Description: | BACKGROUND AND PURPOSE: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants' age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset.METHODS: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level.RESULTS: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4-165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3-26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0-20.9], +6.1 correct on AAT Token Test [CI, 3.2-8.9]; +9.3 Boston Naming Test points [CI, 4.7-13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5-1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9-24.4]; +5.3 correct on AAT Token Test [CI, 1.7-8.8]; +11.1 Boston Naming Test points [CI, 5.7-16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7-1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from ... |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33719515; info:eu-repo/semantics/altIdentifier/wos/WOS:000644656300040; volume:52; issue:5; firstpage:1778; lastpage:1787; numberofpages:10; journal:STROKE; https://hdl.handle.net/11562/1040156; https://doi.org/10.1161/STROKEAHA.120.031162 |
| DOI: | 10.1161/STROKEAHA.120.031162 |
| Availability: | https://hdl.handle.net/11562/1040156 https://doi.org/10.1161/STROKEAHA.120.031162 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.5461CF07 |
| Database: | BASE |
| DOI: | 10.1161/STROKEAHA.120.031162 |
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