Academic Journal
Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia
| Τίτλος: | Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia |
|---|---|
| Συγγραφείς: | Chu, TW, Hu, SW, Wei, B, Wang, Y, Liu, XQ, Wang, XY |
| Συνεισφορές: | Wang, XY (reprint author), Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China., Peking Univ, Coll Chem & Mol Engn, Dept Appl Chem, Beijing 100871, Peoples R China., Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China. |
| Πηγή: | SCI ; PubMed |
| Στοιχεία εκδότη: | 生物有机化学与医药化学通讯 |
| Έτος έκδοσης: | 2004 |
| Συλλογή: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| Θεματικοί όροι: | 4-nitroimidazole, hypoxia imaging agent, biodistribution, tumor, TC-99M COMPLEXES, IN-VITRO, NITROIMIDAZOLES, METRONIDAZOLE, BEARING |
| Περιγραφή: | 1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N41PA) was synthesized. The biodistribution of Tc-99m-N41PA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that Tc-99m-N41PA would be a marker for imaging tumor hypoxia. (C) 2003 Elsevier Ltd. All rights reserved. ; Chemistry, Medicinal ; Chemistry, Organic ; SCI(E) ; PubMed ; 34 ; ARTICLE ; 3 ; 747-749 ; 14 |
| Τύπος εγγράφου: | journal/newspaper |
| Γλώσσα: | English |
| Relation: | 678148; https://hdl.handle.net/20.500.11897/200011; WOS:000188611500038 |
| DOI: | 10.1016/j/bmcl.2003.11.017 |
| Διαθεσιμότητα: | https://hdl.handle.net/20.500.11897/200011 https://doi.org/10.1016/j/bmcl.2003.11.017 |
| Αριθμός Καταχώρησης: | edsbas.5434A221 |
| Βάση Δεδομένων: | BASE |
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