Academic Journal
Clinical implications of lowering episcleral venous pressure in the management of glaucoma and the use of Rho kinase inhibitors
| Τίτλος: | Clinical implications of lowering episcleral venous pressure in the management of glaucoma and the use of Rho kinase inhibitors |
|---|---|
| Συγγραφείς: | Sit, AJ, Aihara, M, Khawaja, AP, Lin, SC, Mansouri, K, Miki, A, Park, KH, Pfeiffer, N, Weinreb, RN |
| Πηγή: | Survey of Ophthalmology (2025) (In press). |
| Έτος έκδοσης: | 2025 |
| Συλλογή: | University College London: UCL Discovery |
| Θεματικοί όροι: | Episcleral venous pressure, EVP, Glaucoma, Netarsudil, Ripasudil, ROCK inhibition, Aqueous humor outflow, IOP lowering |
| Περιγραφή: | There has been limited success in both measuring and modifying episcleral venous pressure (EVP) in clinical practice. Understanding the potential role of EVP in the management of glaucoma for different patients may allow for more individualized treatment approaches. To explore the clinical implications of lowering EVP, an international group of 9 glaucoma experts (the ENGAGE Global Expert Working Group) convened to bridge the gap between the current literature and evidence with clinical opinion and best practices. This review summarizes insights from the group on the effect of current medical therapies on EVP and its potential impact. It also discusses unmet investigational needs to enhance the understanding of EVP, as well as the challenges associated with the measurement and treatment of EVP. Regardless of the relatively modest EVP reductions achieved with current treatments, EVP lowering may have clinical significance in patients with glaucoma, particularly those with low intraocular pressure (IOP). Those who might benefit include patients with elevated EVP; normal-tension glaucoma; undergoing trabecular meshwork bypass surgery, goniotomy, or selective laser trabeculoplasty; or requiring additional IOP lowering to the low teens or with a lower-than-usual target IOP. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10207398/ |
| Διαθεσιμότητα: | https://discovery.ucl.ac.uk/id/eprint/10207398/1/1-s2.0-S0039625725000529-main.pdf https://discovery.ucl.ac.uk/id/eprint/10207398/ |
| Rights: | open |
| Αριθμός Καταχώρησης: | edsbas.539DA33B |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://discovery.ucl.ac.uk/id/eprint/10207398/1/1-s2.0-S0039625725000529-main.pdf# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
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| Header | DbId: edsbas DbLabel: BASE An: edsbas.539DA33B RelevancyScore: 970 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 969.935607910156 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Clinical implications of lowering episcleral venous pressure in the management of glaucoma and the use of Rho kinase inhibitors – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sit%2C+AJ%22">Sit, AJ</searchLink><br /><searchLink fieldCode="AR" term="%22Aihara%2C+M%22">Aihara, M</searchLink><br /><searchLink fieldCode="AR" term="%22Khawaja%2C+AP%22">Khawaja, AP</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+SC%22">Lin, SC</searchLink><br /><searchLink fieldCode="AR" term="%22Mansouri%2C+K%22">Mansouri, K</searchLink><br /><searchLink fieldCode="AR" term="%22Miki%2C+A%22">Miki, A</searchLink><br /><searchLink fieldCode="AR" term="%22Park%2C+KH%22">Park, KH</searchLink><br /><searchLink fieldCode="AR" term="%22Pfeiffer%2C+N%22">Pfeiffer, N</searchLink><br /><searchLink fieldCode="AR" term="%22Weinreb%2C+RN%22">Weinreb, RN</searchLink> – Name: TitleSource Label: Source Group: Src Data: Survey of Ophthalmology (2025) (In press). – Name: DatePubCY Label: Publication Year Group: Date Data: 2025 – Name: Subset Label: Collection Group: HoldingsInfo Data: University College London: UCL Discovery – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Episcleral+venous+pressure%22">Episcleral venous pressure</searchLink><br /><searchLink fieldCode="DE" term="%22EVP%22">EVP</searchLink><br /><searchLink fieldCode="DE" term="%22Glaucoma%22">Glaucoma</searchLink><br /><searchLink fieldCode="DE" term="%22Netarsudil%22">Netarsudil</searchLink><br /><searchLink fieldCode="DE" term="%22Ripasudil%22">Ripasudil</searchLink><br /><searchLink fieldCode="DE" term="%22ROCK+inhibition%22">ROCK inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22Aqueous+humor+outflow%22">Aqueous humor outflow</searchLink><br /><searchLink fieldCode="DE" term="%22IOP+lowering%22">IOP lowering</searchLink> – Name: Abstract Label: Description Group: Ab Data: There has been limited success in both measuring and modifying episcleral venous pressure (EVP) in clinical practice. Understanding the potential role of EVP in the management of glaucoma for different patients may allow for more individualized treatment approaches. To explore the clinical implications of lowering EVP, an international group of 9 glaucoma experts (the ENGAGE Global Expert Working Group) convened to bridge the gap between the current literature and evidence with clinical opinion and best practices. This review summarizes insights from the group on the effect of current medical therapies on EVP and its potential impact. It also discusses unmet investigational needs to enhance the understanding of EVP, as well as the challenges associated with the measurement and treatment of EVP. Regardless of the relatively modest EVP reductions achieved with current treatments, EVP lowering may have clinical significance in patients with glaucoma, particularly those with low intraocular pressure (IOP). Those who might benefit include patients with elevated EVP; normal-tension glaucoma; undergoing trabecular meshwork bypass surgery, goniotomy, or selective laser trabeculoplasty; or requiring additional IOP lowering to the low teens or with a lower-than-usual target IOP. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Format Label: File Description Group: SrcInfo Data: application/pdf – Name: Language Label: Language Group: Lang Data: English – Name: NoteTitleSource Label: Relation Group: SrcInfo Data: https://discovery.ucl.ac.uk/id/eprint/10207398/ – Name: URL Label: Availability Group: URL Data: https://discovery.ucl.ac.uk/id/eprint/10207398/1/1-s2.0-S0039625725000529-main.pdf<br />https://discovery.ucl.ac.uk/id/eprint/10207398/ – Name: Copyright Label: Rights Group: Cpyrght Data: open – Name: AN Label: Accession Number Group: ID Data: edsbas.539DA33B |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.539DA33B |
| RecordInfo | BibRecord: BibEntity: Languages: – Text: English Subjects: – SubjectFull: Episcleral venous pressure Type: general – SubjectFull: EVP Type: general – SubjectFull: Glaucoma Type: general – SubjectFull: Netarsudil Type: general – SubjectFull: Ripasudil Type: general – SubjectFull: ROCK inhibition Type: general – SubjectFull: Aqueous humor outflow Type: general – SubjectFull: IOP lowering Type: general Titles: – TitleFull: Clinical implications of lowering episcleral venous pressure in the management of glaucoma and the use of Rho kinase inhibitors Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sit, AJ – PersonEntity: Name: NameFull: Aihara, M – PersonEntity: Name: NameFull: Khawaja, AP – PersonEntity: Name: NameFull: Lin, SC – PersonEntity: Name: NameFull: Mansouri, K – PersonEntity: Name: NameFull: Miki, A – PersonEntity: Name: NameFull: Park, KH – PersonEntity: Name: NameFull: Pfeiffer, N – PersonEntity: Name: NameFull: Weinreb, RN IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2025 Identifiers: – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa Titles: – TitleFull: Survey of Ophthalmology (2025) (In press Type: main |
| ResultId | 1 |