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A computer model of human atria with reasonable computation load and realistic anatomical properties

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Τίτλος: A computer model of human atria with reasonable computation load and realistic anatomical properties
Συγγραφείς: Blanc, O., Virag, N., Vesin, J. M., Kappenberger, L.
Έτος έκδοσης: 2001
Συλλογή: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
Θεματικοί όροι: Atrial Fibrillation/physiopathology Atrial Function Biomedical Engineering *Computer Simulation Electrophysiology Heart/*anatomy & histology/*physiology Heart Atria/anatomy & histology Humans Models, Anatomic *Models, Cardiovascular User-Computer Interface
Περιγραφή: Atrial fibrillation is the most frequent arrhythmia, provoking discomfort, heart failure and arterial embolisms. The aim of this work is to develop a simplified anatomical computer model of human atria for the study of atrial arrhythmias and the understanding of electrical propagation mechanisms. With the model we propose, up to 40 s of real-time propagation have been simulated on a single-processor computer. The size and the electrophysiological properties of the simulated atria are within realistic values and information about anatomy has been taken into account in a three-dimensional structure. Besides normal sinus beat, pathological phenomena such as flutter and fibrillation have been induced using a programmed stimulation protocol. One important observation in our model is that atrial arrhythmias are a combination of functional and anatomical reentries and that the geometry plays an important role. This virtual atrium can reproduce electrophysiological observations made in humans but with the advantage of showing in great detail how arrhythmias are initiated and sustained. Such details are difficult or impossible to study in humans. This model will serve us as a tool to evaluate the impact of new therapeutic strategies and to improve them.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: unknown
ISSN: 0018-9294
Relation: IEEE Transactions on Biomedical Engineering; https://iris.unil.ch/handle/iris/258598; serval:BIB_DB9C804FEACA; 000171680000002
DOI: 10.1109/10.959315
Διαθεσιμότητα: https://iris.unil.ch/handle/iris/258598
https://doi.org/10.1109/10.959315
Αριθμός Καταχώρησης: edsbas.5134C2F1
Βάση Δεδομένων: BASE
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  – Url: https://iris.unil.ch/handle/iris/258598#
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  Data: A computer model of human atria with reasonable computation load and realistic anatomical properties
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  Data: <searchLink fieldCode="AR" term="%22Blanc%2C+O%2E%22">Blanc, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Virag%2C+N%2E%22">Virag, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Vesin%2C+J%2E+M%2E%22">Vesin, J. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kappenberger%2C+L%2E%22">Kappenberger, L.</searchLink>
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  Data: 2001
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  Data: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
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  Data: <searchLink fieldCode="DE" term="%22Atrial+Fibrillation%2Fphysiopathology+Atrial+Function+Biomedical+Engineering+*Computer+Simulation+Electrophysiology+Heart%2F*anatomy+%26+histology%2F*physiology+Heart+Atria%2Fanatomy+%26+histology+Humans+Models%22">Atrial Fibrillation/physiopathology Atrial Function Biomedical Engineering *Computer Simulation Electrophysiology Heart/*anatomy & histology/*physiology Heart Atria/anatomy & histology Humans Models</searchLink><br /><searchLink fieldCode="DE" term="%22Anatomic+*Models%22">Anatomic *Models</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+User-Computer+Interface%22">Cardiovascular User-Computer Interface</searchLink>
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  Data: Atrial fibrillation is the most frequent arrhythmia, provoking discomfort, heart failure and arterial embolisms. The aim of this work is to develop a simplified anatomical computer model of human atria for the study of atrial arrhythmias and the understanding of electrical propagation mechanisms. With the model we propose, up to 40 s of real-time propagation have been simulated on a single-processor computer. The size and the electrophysiological properties of the simulated atria are within realistic values and information about anatomy has been taken into account in a three-dimensional structure. Besides normal sinus beat, pathological phenomena such as flutter and fibrillation have been induced using a programmed stimulation protocol. One important observation in our model is that atrial arrhythmias are a combination of functional and anatomical reentries and that the geometry plays an important role. This virtual atrium can reproduce electrophysiological observations made in humans but with the advantage of showing in great detail how arrhythmias are initiated and sustained. Such details are difficult or impossible to study in humans. This model will serve us as a tool to evaluate the impact of new therapeutic strategies and to improve them.
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