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Canine presumed glial brain tumours treated with radiotherapy: Is there an inferior outcome in tumours contacting the subventricular zone?

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Τίτλος: Canine presumed glial brain tumours treated with radiotherapy: Is there an inferior outcome in tumours contacting the subventricular zone?
Συγγραφείς: Rohrer Bley C., Staudinger C., Bley T., Marconato L., Sabattini S., Beckmann K.
Συνεισφορές: Rohrer Bley C., Staudinger C., Bley T., Marconato L., Sabattini S., Beckmann K.
Έτος έκδοσης: 2021
Συλλογή: IRIS Università degli Studi di Bologna (CRIS - Current Research Information System)
Θεματικοί όροι: brain tumour, dog, drop metastasi, glioma, neuroepithelial tumour, radiation therapy
Περιγραφή: Post-treatment outcome in canine glial tumours is described with a broad range of survival times between 2 and 28 months. After surgery or radiation therapy, the tumours may progress locally or spread within the central nervous system. It is unknown if tumour- or patient-specific factors influence prognosis. In humans, glioblastoma involving the subventricular zone has been found to recur distantly, with shortened time to progression and overall survival. We included 32 dogs irradiated for a presumptive primary glial brain tumour in this retrospective cohort study. Tumours were grouped relative to subventricular zone contact and overt ventricular invasion assessing pre-treatment magnetic resonance images. Median time to progression (TTP) for all cases was 534 days (95%CI, 310–758), with a significantly shorter TTP in dogs with lesions at the subventricular zone (median TTP, 260 vs. 687 days; p=.049). Tumours at the subventricular zone progressed more often (p=.001), and more likely as CNS-metastasis (52.9% vs. 13.3%, p=.028). Median overall survival (OS) was 489 days (95%CI, 147–831) and median tumour-specific survival 609 days (95%CI, 382–835). Involvement of the subventricular zone was significantly associated with a shorter tumour-specific survival (median, 306 vs. 719 days; p=.044). Glial tumours contacting the subventricular zone in dogs have a shorter tumour-specific survival and a higher rate of progression and CNS-metastasis. Despite local tumour control, metastasis must be considered and should prompt further treatment approaches.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: ELETTRONICO
Γλώσσα: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/33900018; info:eu-repo/semantics/altIdentifier/wos/WOS:000648563300001; volume:20; firstpage:29; lastpage:37; numberofpages:9; journal:VETERINARY AND COMPARATIVE ONCOLOGY; https://hdl.handle.net/11585/893851
DOI: 10.1111/vco.12703
Διαθεσιμότητα: https://hdl.handle.net/11585/893851
https://doi.org/10.1111/vco.12703
Rights: info:eu-repo/semantics/openAccess ; license:Licenza per accesso libero gratuito ; license uri:iris.PUB01
Αριθμός Καταχώρησης: edsbas.4A927635
Βάση Δεδομένων: BASE
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  – Url: https://hdl.handle.net/11585/893851#
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  Data: Canine presumed glial brain tumours treated with radiotherapy: Is there an inferior outcome in tumours contacting the subventricular zone?
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  Data: <searchLink fieldCode="AR" term="%22Rohrer+Bley+C%2E%22">Rohrer Bley C.</searchLink><br /><searchLink fieldCode="AR" term="%22Staudinger+C%2E%22">Staudinger C.</searchLink><br /><searchLink fieldCode="AR" term="%22Bley+T%2E%22">Bley T.</searchLink><br /><searchLink fieldCode="AR" term="%22Marconato+L%2E%22">Marconato L.</searchLink><br /><searchLink fieldCode="AR" term="%22Sabattini+S%2E%22">Sabattini S.</searchLink><br /><searchLink fieldCode="AR" term="%22Beckmann+K%2E%22">Beckmann K.</searchLink>
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  Data: Rohrer Bley C.<br />Staudinger C.<br />Bley T.<br />Marconato L.<br />Sabattini S.<br />Beckmann K.
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  Data: IRIS Università degli Studi di Bologna (CRIS - Current Research Information System)
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  Data: <searchLink fieldCode="DE" term="%22brain+tumour%22">brain tumour</searchLink><br /><searchLink fieldCode="DE" term="%22dog%22">dog</searchLink><br /><searchLink fieldCode="DE" term="%22drop+metastasi%22">drop metastasi</searchLink><br /><searchLink fieldCode="DE" term="%22glioma%22">glioma</searchLink><br /><searchLink fieldCode="DE" term="%22neuroepithelial+tumour%22">neuroepithelial tumour</searchLink><br /><searchLink fieldCode="DE" term="%22radiation+therapy%22">radiation therapy</searchLink>
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  Data: Post-treatment outcome in canine glial tumours is described with a broad range of survival times between 2 and 28 months. After surgery or radiation therapy, the tumours may progress locally or spread within the central nervous system. It is unknown if tumour- or patient-specific factors influence prognosis. In humans, glioblastoma involving the subventricular zone has been found to recur distantly, with shortened time to progression and overall survival. We included 32 dogs irradiated for a presumptive primary glial brain tumour in this retrospective cohort study. Tumours were grouped relative to subventricular zone contact and overt ventricular invasion assessing pre-treatment magnetic resonance images. Median time to progression (TTP) for all cases was 534 days (95%CI, 310–758), with a significantly shorter TTP in dogs with lesions at the subventricular zone (median TTP, 260 vs. 687 days; p=.049). Tumours at the subventricular zone progressed more often (p=.001), and more likely as CNS-metastasis (52.9% vs. 13.3%, p=.028). Median overall survival (OS) was 489 days (95%CI, 147–831) and median tumour-specific survival 609 days (95%CI, 382–835). Involvement of the subventricular zone was significantly associated with a shorter tumour-specific survival (median, 306 vs. 719 days; p=.044). Glial tumours contacting the subventricular zone in dogs have a shorter tumour-specific survival and a higher rate of progression and CNS-metastasis. Despite local tumour control, metastasis must be considered and should prompt further treatment approaches.
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  Data: info:eu-repo/semantics/altIdentifier/pmid/33900018; info:eu-repo/semantics/altIdentifier/wos/WOS:000648563300001; volume:20; firstpage:29; lastpage:37; numberofpages:9; journal:VETERINARY AND COMPARATIVE ONCOLOGY; https://hdl.handle.net/11585/893851
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  Data: 10.1111/vco.12703
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  Data: https://hdl.handle.net/11585/893851<br />https://doi.org/10.1111/vco.12703
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    Subjects:
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      – SubjectFull: drop metastasi
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