Academic Journal
Προβολή σε EDS

Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression
Συγγραφείς: Cha, Jiook, Guffanti, Guia, Gingrich, Jay A., Talati, Ardesheer, Wickramaratne, Priya J., Weissman, Myrna M., Posner, Jonathan Eric
Έτος έκδοσης: 2018
Συλλογή: Columbia University: Academic Commons
Θεματικοί όροι: Serotoninergic mechanisms, Impulse control disorders, Brain--Physiology, Genetics, Human genetics--Variation
Περιγραφή: Serotonergic neurotransmission, potentially through effects on the brain’s default mode network (DMN), may regulate aspects of attention including impulse control. Indeed, genetic variants of the serotonin transporter (5-HTT) have been implicated in impulsivity and related psychopathology. Yet it remains unclear the mechanism by which the 5-HTT genetic variants contribute to individual variability in impulse control. Here, we tested whether DMN connectivity mediates an association between the 5-HTT genetic variants and impulsivity. Participants (N = 92) were from a family cohort study of depression in which we have previously shown a broad distribution of 5-HTT variants. We genotyped for 5-HTTLPR and rs25531 (stratified by transcriptional efficiency: 8 low/low, 53 low/high, and 31 high/high), estimated DMN structural connectivity using diffusion probabilistic tractography, and assessed behavioral measures of impulsivity (from 12 low/low, 48 low/high, and 31 high/high) using the Continuous Performance Task. We found that low transcriptional efficiency genotypes were associated with decreased connection strength between the posterior DMN and the superior frontal gyrus (SFG). Path modeling demonstrated that decreased DMN–SFG connectivity mediated the association between low-efficiency genotypes and increased impulsivity. Taken together, this study suggests a gene-brain-behavior pathway that perhaps underlies the role of the serotonergic neuromodulation in impulse control.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
DOI: 10.7916/d8-744g-7e82
Διαθεσιμότητα: https://doi.org/10.7916/d8-744g-7e82
Αριθμός Καταχώρησης: edsbas.48C455F8
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doi.org/10.7916/d8-744g-7e82#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.48C455F8
RelevancyScore: 872
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 872.436645507813
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Cha%2C+Jiook%22">Cha, Jiook</searchLink><br /><searchLink fieldCode="AR" term="%22Guffanti%2C+Guia%22">Guffanti, Guia</searchLink><br /><searchLink fieldCode="AR" term="%22Gingrich%2C+Jay+A%2E%22">Gingrich, Jay A.</searchLink><br /><searchLink fieldCode="AR" term="%22Talati%2C+Ardesheer%22">Talati, Ardesheer</searchLink><br /><searchLink fieldCode="AR" term="%22Wickramaratne%2C+Priya+J%2E%22">Wickramaratne, Priya J.</searchLink><br /><searchLink fieldCode="AR" term="%22Weissman%2C+Myrna+M%2E%22">Weissman, Myrna M.</searchLink><br /><searchLink fieldCode="AR" term="%22Posner%2C+Jonathan+Eric%22">Posner, Jonathan Eric</searchLink>
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2018
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Columbia University: Academic Commons
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Serotoninergic+mechanisms%22">Serotoninergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Impulse+control+disorders%22">Impulse control disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Brain--Physiology%22">Brain--Physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genetics--Variation%22">Human genetics--Variation</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Serotonergic neurotransmission, potentially through effects on the brain’s default mode network (DMN), may regulate aspects of attention including impulse control. Indeed, genetic variants of the serotonin transporter (5-HTT) have been implicated in impulsivity and related psychopathology. Yet it remains unclear the mechanism by which the 5-HTT genetic variants contribute to individual variability in impulse control. Here, we tested whether DMN connectivity mediates an association between the 5-HTT genetic variants and impulsivity. Participants (N = 92) were from a family cohort study of depression in which we have previously shown a broad distribution of 5-HTT variants. We genotyped for 5-HTTLPR and rs25531 (stratified by transcriptional efficiency: 8 low/low, 53 low/high, and 31 high/high), estimated DMN structural connectivity using diffusion probabilistic tractography, and assessed behavioral measures of impulsivity (from 12 low/low, 48 low/high, and 31 high/high) using the Continuous Performance Task. We found that low transcriptional efficiency genotypes were associated with decreased connection strength between the posterior DMN and the superior frontal gyrus (SFG). Path modeling demonstrated that decreased DMN–SFG connectivity mediated the association between low-efficiency genotypes and increased impulsivity. Taken together, this study suggests a gene-brain-behavior pathway that perhaps underlies the role of the serotonergic neuromodulation in impulse control.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.7916/d8-744g-7e82
– Name: URL
  Label: Availability
  Group: URL
  Data: https://doi.org/10.7916/d8-744g-7e82
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.48C455F8
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.48C455F8
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.7916/d8-744g-7e82
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Serotoninergic mechanisms
        Type: general
      – SubjectFull: Impulse control disorders
        Type: general
      – SubjectFull: Brain--Physiology
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Human genetics--Variation
        Type: general
    Titles:
      – TitleFull: Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Cha, Jiook
      – PersonEntity:
          Name:
            NameFull: Guffanti, Guia
      – PersonEntity:
          Name:
            NameFull: Gingrich, Jay A.
      – PersonEntity:
          Name:
            NameFull: Talati, Ardesheer
      – PersonEntity:
          Name:
            NameFull: Wickramaratne, Priya J.
      – PersonEntity:
          Name:
            NameFull: Weissman, Myrna M.
      – PersonEntity:
          Name:
            NameFull: Posner, Jonathan Eric
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
ResultId 1