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Calcium supplementation during trauma resuscitation: a propensity score-matched analysis from the TraumaRegister DGU®

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Title: Calcium supplementation during trauma resuscitation: a propensity score-matched analysis from the TraumaRegister DGU®
Authors: Helsloot, Dries, Fitzgerald, Mark, Lefering, Rolf, Groombridge, Christopher, Becaus, Nathalie, Verelst, Sandra, Missant, Carlo, The TraumaRegister DGU
Source: http://lobid.org/resources/99370670818906441#!, 28(1):222.
Publication Year: 2024
Collection: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Subject Terms: Aged [MeSH], Wounds and Injuries/mortality [MeSH], Calcium, Trauma resuscitation, Hospital Mortality [MeSH], Cohort Studies [MeSH], Calcium/blood [MeSH], Mortality, Male [MeSH], Dietary Supplements [MeSH], Resuscitation/statistics, Calcium/therapeutic use [MeSH], Registries/statistics, Propensity Score [MeSH], Calcium/analysis [MeSH], Wounds and Injuries/therapy [MeSH], Female [MeSH], Adult [MeSH], Humans [MeSH], Logistic Models [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Research, Hypocalcemia, Resuscitation/methods [MeSH]
Time: Trauma Care for the 21st Century
Description: Abstract Background In major trauma patients, hypocalcemia is associated with increased mortality. Despite the absence of strong evidence on causality, early calcium supplementation has been recommended. This study investigates whether calcium supplementation during trauma resuscitation provides a survival benefit. Methods We conducted a retrospective analysis using data from the TraumaRegister DGU® (2015–2019), applying propensity score matching to balance demographics, injury severity, and management between major trauma patients with and without calcium supplementation. 6 h mortality, 24 h mortality, and in-hospital mortality were considered as primary outcome parameters. Results Within a cohort of 28,323 directly admitted adult major trauma patients at a European trauma center, 1593 (5.6%) received calcium supplementation. Using multivariable logistic regression to generate propensity scores, two comparable groups of 1447 patients could be matched. No significant difference in early mortality (6 h and 24 h) was observed, while in-hospital mortality appeared higher in those with calcium supplementation (28.3% vs. 24.5%, P = 0.020), although this was not significant when adjusted for predicted mortality (P = 0.244). Conclusion In this matched cohort, no evidence was found for or against a survival benefit from calcium supplementation during trauma resuscitation. Further research should focus on understanding the dynamics and kinetics of ionized calcium levels in major trauma patients and identify if ...
Document Type: article in journal/newspaper
Language: English
ISBN: 978-9937-0-6708-9
9937-0-6708-1
Relation: https://repository.publisso.de/resource/frl:6524036; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227138/
DOI: 10.1186/s13054-024-05002-1
Availability: https://repository.publisso.de/resource/frl:6524036
https://doi.org/10.1186/s13054-024-05002-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227138/
Rights: https://creativecommons.org/licenses/by/4.0/
Accession Number: edsbas.47710485
Database: BASE
Description
ISBN:9789937067089
9937067081
DOI:10.1186/s13054-024-05002-1