Academic Journal

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission
Συγγραφείς: Aggarwal, D, Warne, B, Jahun, AS, Hamilton, WL, Fieldman, T, du Plessis, L, Hill, V, Blane, B, Watkins, E, Wright, E, Hall, G, Ludden, C, Myers, R, Hosmillo, M, Chaudhry, Y, Pinckert, ML, Georgana, I, Izuagbe, R, Leek, D, Nsonwu, O, Hughes, GJ, Packer, S, Page, AJ, Metaxaki, M, Fuller, S, Weale, G, Holgate, J, Brown, CA, Orton, A, Douthwaite, J, Rees, S, Brown, C, Clark, R, Jones, DR, Kuenzi, F, Rankin, J, Waddell, I, Maxwell, P, Matheson, N, Abell, C, Braithwaite, V, Brierley, C, Crowcroft, J, Dahal, A, Faulkner, K, Glover, M, Goodfellow, I, Greatorex, J, James, L, Lehner, P, Leslie, I, Liddell, K, Margolis, B, Morgan, S, Sheridan, L, Valletta, S, Vignoles, A, Vinnell, M, Wills, M, Hilborne, S, Berry, S, Kahkeshi, MB, Hancock, D, Winster, J, Enright, J, Samworth, R, Samtani, V, Ahmadi-Assalemi, G, Feather, T, Goodall, R, Hoensch, S, Johnson, D, Hunt, M, Mathieson, N, Nikitina, K, Sheldrake, Z, Keen, M, Sato, A, Connor, D, Tolhurst, J, Williman, J, Hollamby, V, Jordan, S, Fatseas, T, Taylor, P, Georgiou, C, Caspersz, M, McNulty, C, Davies, R, Clarke, R, Danaei, D, Dyer, R, Glew, R, Lambson, O, Gibbs, K, Mozdzen, B, Raub, G, Radecki, A, White, P, Hughes, R, Gransden, L, Ceaser, M, Sing, R, Wilson, K, Parlikad, A, Dhada, M, Ridgman, T, Mungovan, D, Matthews, S, Searle, P, Mills, J, Neely, A, Henderson, R, Murphy, E, Russell, M, Freeling, A, Poppitt, S, Tynan, J, Knapton, J, Marchetti, F, Angelis, DD, Feltwell, T, Hadjirin, NF, Jahun, A, Pinckert, M, Shaw, A, Chaudhry, A, Brown, NM, Mactavous, L, Hannan, S, Hosaja, A, Leong, C, Wright, J, Quinnell, N, Workman, C, Ferris, M, Wright, G, Brooks, E, Carabelli, AM, Churcher, CM, Galai, K, Girgis, ST, Gupta, RK, McManus, GM, Palmer, S, Peacock, SJ, Smith, KS, Allara, E, Bibby, D, Bishop, C, Bosworth, A, Bradshaw, D, Chalker, V, Chand, M, Dabrera, G, Ellaby, N, Gallagher, E, Groves, N, Harrison, I, Hartman, H, Hopes, R, Hubb, J, Hutchings, S, Lackenby, A, Ledesma, J, Lee, D, Manesis, N, Manso, C, Mbisa, T, Miah, S, Muir, P, Osman, H, Patel, V, Pearson, C, Platt, S, Pymont, HM, Ramsay, M, Robinson, E, Schaefer, U, Thornton, A, Twohig, KA, Vipond, IB, Williams, D, Aigrain, L, Alderton, A, Amato, R, Ariani, CV, Barrett, J, Bassett, AR, Beale, MA, Beaver, C, Bellis, KL, Betteridge, E, Bonfield, J, Bronner, IF, Chapman, MHS, Danesh, J, Dorman, MJ, Drury, E, Durham, J, Farr, BW, Foulser, L, Goncalves, S, Goodwin, S, Gourtovaia, M, Jackson, DK, James, K, Jamrozy, D, Johnston, I, Kane, L, Kay, S, Keatley, J-P, Kwiatkowski, D, Langford, CF, Lawniczak, M, Lensing, SV, Leonard, S, Letchford, L, Lewis, K, Liddle, J, Livett, R, Lo, S, Makunin, A, Martincorena, I, McCarthy, S, McGuigan, S, Moll, RJ, Nelson, R, Oliver, K, Park, NR, Patel, M, Prestwood, L, Puethe, C, Quail, MA, Rajan, D, Rajatileka, S, Redshaw, NM, Scott, C, Shirley, L, Sillitoe, J, Thurston, SAJ, Tonkin-Hill, G, Tovar-Corona, JM, Weldon, D, Whitwham, A, Attwood, SW, Zamudio, ME, Francois, S, Gutierrez, B, Kraemer, MUG, Raghwani, J, Vasylyeva, TI, Zarebski, AE, Alikhan, N-F, Aydin, A, Baker, DJ, de Oliveira Martins, L, Kay, GL, Le-Viet, T, Mather, AE, Meadows, L, O’Grady, J, Rudder, S, Trotter, AJ, Illingworth, CJ, Jackson, C, Aranday-Cortes, E, Asamaphan, P, Broos, A, Carmichael, SN, da Silva Filipe, A, Hughes, J, Jesudason, NG, Johnson, N, Li, KK, Mair, D, Nichols, J, Nickbakhsh, S, Niebel, MO, Nomikou, K, Orton, RJ, Robertson, DL, Shah, RN, Shepherd, JG, Singer, JB, Starinskij, I, Thomson, EC, Tong, L, Vattipally, S, Ash, A, Koshy, C, Cortes, N, Kidd, S, Lynch, J, Moore, N, Mori, M, Wise, E, Curran, T, Fairley, DJ, McKenna, JP, Adams, H, Bonsall, D, Fraser, C, Golubchik, T, Cogger, BJ, Hassan-Ibrahim, MO, Malone, CS, Reynolds, N, Wantoch, M, Afifi, S, Beer, R, John, M, Maksimovic, J, McCluggage, K, Spellman, K, Bresner, C, Connor, TR, Fuller, W, Guest, M, Gulliver, H, Kitchen, C, Marchbank, A, Merrick, I, Munn, R, Price, A, Southgate, J, Workman, T, Patel, A, Snell, LB, Batra, R, Charalampous, T, Edgeworth, J, Nebbia, G, Beckett, AH, Robson, SC, Aanensen, DM, Abudahab, K, Menegazzo, M, Taylor, BEW, Underwood, AP, Yeats, CA, Berry, L, Boswell, T, Clark, G, Fleming, VM, Howson-Wells, HC, Jones, C, Joseph, A, Khakh, M, Lister, MM, Smith, W, Willingham, I, Bird, P, Fallon, K, Helmer, T, Holmes, C, Tang, J, Blakey, V, Campbell, S, Raviprakash, V, Sheriff, N, Williams, L-A, Carlile, M, Debebe, J, Holmes, N, Loose, MW, Moore, C, Sang, F, Wright, V, Coll, F, Betancor, G, Signell, AW, Wilson, HD, Davis, T, Eldirdiri, S, Kenyon, A, Torok, ME, Lowe, H, Moses, S, Bedford, L, Moore, J, Stonehouse, S, Awan, AR, Fisher, CL, BoYes, J, Atkinson, L, Breuer, J, Brown, JR, Harris, KA, Lee, JCD, Shah, D, Storey, N, Flaviani, F, Alcolea-Medina, A, Vernet, G, Williams, R, Chapman, MR, Chatterton, W, Heaney, J, Levett, LJ, Pusok, M, Xu-McCrae, L, Bashton, M, Smith, DL, Young, GR, Bolt, F, Cox, A, Holmes, A, Madona, P, Mookerjee, S, Price, J, Randell, PA, Boyd, O, Nascimento, FF, Geidelberg, L, Johnson, R, Jorgensen, D, Ragonnet-Cronin, M, Rowan, A, Siveroni, I, Taylor, GP, Volz, EM, Smollett, KL, Loman, NJ, McMurray, C, McNally, A, Nicholls, S, Poplawski, R, Quick, J, Rowe, W, Stockton, J, Nunez, RTM, Breen, C, Cowell, A, Mason, J, O’Toole, E, Robinson, TI, Watts, J, Sluga, G, Ahmad, SSY, George, RP, Machin, NW, Halstead, F, Hogsden, W, Sivaprakasam, V, Carden, H, Hale, AD, Harper, KL, Macfarlane-Smith, LR, Burton-Fanning, S, Collins, J, Eltringham, G, Payne, BAI, Taha, Y, Waugh, S, O’Brien, S, Rushton, S, Blacow, R, Bradley, A, Maclean, A, Mollett, G, Dewar, R, McHugh, MP, Templeton, KE, Wastenge, E, Coupland, L, Dervisevic, S, Meader, EJ, Stanley, R, Smith, L, Barton, E, Graham, C, Padgett, D, Scott, G, Greenaway, J, Swindells, E, McCann, CM, Nelson, A, Yew, WC, Andersson, M, Crook, D, Eyre, D, Justice, A, Peto, T, Duckworth, N, Sloan, TJ, Walsh, S, Bicknell, K, Chauhan, AJ, Elliott, S, Glaysher, S, Impey, R, Lloyd, A, Wyllie, S, Levene, N, Monaghan, L, Bradley, DT, Wyatt, T, Curran, MD, Parmar, S, Holden, MTG, Shaaban, S, Adams, A, Asad, H, Birchley, A, Bull, M, Coombes, J, Corden, S, Cottrell, S, Craine, N, Cronin, M, Davies, A, Lacy, ED, Downing, F, Edwards, S, Evans, JM, Fina, L, Gaskin, A, Gatica-Wilcox, B, Gifford, L, Gilbert, L, Graham, L, Heyburn, D, Hilvers, E, Howe, R, Jones, H, Jones, R, Jones, S, Kumziene-SummerhaYes, S, McKerr, C, Morgan, M, Pacchiarini, N, Perry, M, Plimmer, A, Rey, S, Shankar, G, Taylor, S, Watkins, J, Williams, C, Casey, A, Ratcliffe, L, Acheson, E, Molnar, Z, Simpson, DA, Thompson, T, Auckland, C, Ellard, S, Jones, CR, Knight, BA, Masoli, JAH, Haque, T, Hart, J, Irish-Tavares, D, Mahungu, TW, Witele, E, Dadrah, A, Fenton, ML, Saluja, T, Symmonds, A, Bourgeois, Y, Scarlett, GP, Cook, K, Dent, H, Fearn, C, Goudarzi, S, Loveson, KF, Paul, H, Evans, C, Johnson, K, Partridge, DG, Raza, M, Baker, P, Bonner, S, Essex, S, Liggett, S, Lyons, RA, Mahanama, AIK, Saeed, K, Samaraweera, B, Silveira, S, Wilson-Davies, E, Emanuela, P, Bayzid, N, Cotic, M, Ensell, L, Hartley, JA, Jannoo, R, Karamani, A, Kristiansen, M, Lowe, HL, Roy, S, Westhorpe, AP, Williams, RJ, Williams, CA, Jeremiah, S, Prieto, JA, Grammatopoulos, D, Jones, K, Pandey, S, Beggs, A, Richter, A, Ashcroft, F, Best, A, Crawford, L, Cumley, N, Mayhew, M, Megram, O, Mirza, J, Moles-Garcia, E, Percival, B, Bucca, G, Hesketh, AR, Smith, CP, Davidson, RK, Balcazar, CE, Gallagher, MD, O’Toole, Á, Rambaut, A, Rooke, S, Stanton, TD, Williams, T, Williamson, KA, Bewshea, CM, Farbos, A, Harrison, JW, Jeffries, AR, Manley, R, Michell, SL, Michelsen, ML, Sambles, CM, Studholme, DJ, Temperton, B, Warwick-Dugdale, J, Darby, AC, Eccles, R, Gemmell, M, Gregory, R, Haldenby, ST, Hiscox, JA, Hughes, M, Iturriza-Gomara, M, Jackson, KA, Lucaci, AO, Nelson, C, Paterson, S, Rainbow, L, Turtle, L, Vamos, EE, Webster, HJ, Whitehead, M, Wierzbicki, C, Angyal, A, Brown, R, de Silva, TI, Freeman, TM, Gallis, M, Green, LR, Groves, DC, Keeley, AJ, Lindsey, BB, Louka, SF, Parker, MD, Parsons, PJ, Smith, N, Tucker, RM, Wang, D, Whiteley, M, Wyles, M, Zhang, P, Alam, MT, Baxter, L, Bridgewater, HE, Brown, PE, Cheng, JKJ, Constantinidou, C, Frost, LR, Ott, S, Stark, R, Taylor-Joyce, G, Unnikrishnan, M, Cerda, AC, Merrill, TV, Wilson, RE, Ball, J, Chappell, JG, McClure, PC, Tsoleridis, T, Buck, D, de Cesare, M, Green, A, MacIntyre-Cockett, G, Todd, JA, Trebes, A, Gunson, RN, Cormie, C, Dias, J, Forrest, S, Gill, HK, Higginson, EE, Kermack, LM, Maes, M, Ruis, C, Sridhar, S, Young, J, Howes, R, McFarlane, D, Dougan, G, Pybus, OG, Maxwell, PH, Weekes, MP, Illingworth, C, Harrison, EM, Matheson, NJ, Goodfellow, IG
Στοιχεία εκδότη: Nature Research (part of Springer Nature)
Έτος έκδοσης: 2022
Συλλογή: White Rose Research Online (Universities of Leeds, Sheffield & York)
Περιγραφή: Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: text
Γλώσσα: English
ISSN: 2041-1723
Relation: https://eprints.whiterose.ac.uk/id/eprint/183970/1/s41467-021-27942-w.pdf; Aggarwal, D, Warne, B, Jahun, AS et al. (725 more authors) (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13 (1). 751. ISSN: 2041-1723
Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/183970/
Rights: cc_by_4
Αριθμός Καταχώρησης: edsbas.4637DB8B
Βάση Δεδομένων: BASE