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Immunosupressive phenolic constituents from Hypericum montbretii Spach

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Immunosupressive phenolic constituents from Hypericum montbretii Spach
Συγγραφείς: Demirkiran O., Ahmad Mesaik M., Beynek H., Abbaskhan A., Iqbal Choudhary M.
Έτος έκδοσης: 2013
Συλλογή: Trakya Üniversitesi: Açık Erişim Sistemi
Θεματικοί όροι: Hypericum Monbretii Spach., Il-2 Production, Immunomodulating Inhibitory Activity, Phenolics, Reactive Oxygen Species, T-Cell Proliferation, 5 O 4 Coumaroylquinic Acid, 8'' Biapigenin, Chlorogenic Acid, Hypericum Montbretii Extract, Hyperin, Immunosuppressive Agent, Interleukin 2, Kaempferol, Mangiferin, Methanol, Methyl Chlorogenate, Myricetin 3 Rhamnoside, Phenol Derivative, Phytohemagglutinin, Plant Extract, Quercetin, Quercitrin, Rutoside, Shikimic Acid, Unclassified Drug, Animal Cell, Article, Cell Activation, Controlled Study
Περιγραφή: The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8? biapigenin (7), methyl chlorogenate (8), 5-O-pcoumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 ?g/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: Records of Natural Products; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.14551/17572; 210; 219; Q3
Διαθεσιμότητα: https://hdl.handle.net/20.500.14551/17572
Rights: info:eu-repo/semantics/closedAccess
Αριθμός Καταχώρησης: edsbas.3CDE5837
Βάση Δεδομένων: BASE
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  Availability: 0
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  – Url: https://hdl.handle.net/20.500.14551/17572#
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An: edsbas.3CDE5837
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 775.314270019531
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Immunosupressive phenolic constituents from Hypericum montbretii Spach
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Demirkiran+O%2E%22">Demirkiran O.</searchLink><br /><searchLink fieldCode="AR" term="%22Ahmad+Mesaik+M%2E%22">Ahmad Mesaik M.</searchLink><br /><searchLink fieldCode="AR" term="%22Beynek+H%2E%22">Beynek H.</searchLink><br /><searchLink fieldCode="AR" term="%22Abbaskhan+A%2E%22">Abbaskhan A.</searchLink><br /><searchLink fieldCode="AR" term="%22Iqbal+Choudhary+M%2E%22">Iqbal Choudhary M.</searchLink>
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2013
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Trakya Üniversitesi: Açık Erişim Sistemi
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hypericum+Monbretii+Spach%2E%22">Hypericum Monbretii Spach.</searchLink><br /><searchLink fieldCode="DE" term="%22Il-2+Production%22">Il-2 Production</searchLink><br /><searchLink fieldCode="DE" term="%22Immunomodulating+Inhibitory+Activity%22">Immunomodulating Inhibitory Activity</searchLink><br /><searchLink fieldCode="DE" term="%22Phenolics%22">Phenolics</searchLink><br /><searchLink fieldCode="DE" term="%22Reactive+Oxygen+Species%22">Reactive Oxygen Species</searchLink><br /><searchLink fieldCode="DE" term="%22T-Cell+Proliferation%22">T-Cell Proliferation</searchLink><br /><searchLink fieldCode="DE" term="%225+O+4+Coumaroylquinic+Acid%22">5 O 4 Coumaroylquinic Acid</searchLink><br /><searchLink fieldCode="DE" term="%228''+Biapigenin%22">8'' Biapigenin</searchLink><br /><searchLink fieldCode="DE" term="%22Chlorogenic+Acid%22">Chlorogenic Acid</searchLink><br /><searchLink fieldCode="DE" term="%22Hypericum+Montbretii+Extract%22">Hypericum Montbretii Extract</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperin%22">Hyperin</searchLink><br /><searchLink fieldCode="DE" term="%22Immunosuppressive+Agent%22">Immunosuppressive Agent</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin+2%22">Interleukin 2</searchLink><br /><searchLink fieldCode="DE" term="%22Kaempferol%22">Kaempferol</searchLink><br /><searchLink fieldCode="DE" term="%22Mangiferin%22">Mangiferin</searchLink><br /><searchLink fieldCode="DE" term="%22Methanol%22">Methanol</searchLink><br /><searchLink fieldCode="DE" term="%22Methyl+Chlorogenate%22">Methyl Chlorogenate</searchLink><br /><searchLink fieldCode="DE" term="%22Myricetin+3+Rhamnoside%22">Myricetin 3 Rhamnoside</searchLink><br /><searchLink fieldCode="DE" term="%22Phenol+Derivative%22">Phenol Derivative</searchLink><br /><searchLink fieldCode="DE" term="%22Phytohemagglutinin%22">Phytohemagglutinin</searchLink><br /><searchLink fieldCode="DE" term="%22Plant+Extract%22">Plant Extract</searchLink><br /><searchLink fieldCode="DE" term="%22Quercetin%22">Quercetin</searchLink><br /><searchLink fieldCode="DE" term="%22Quercitrin%22">Quercitrin</searchLink><br /><searchLink fieldCode="DE" term="%22Rutoside%22">Rutoside</searchLink><br /><searchLink fieldCode="DE" term="%22Shikimic+Acid%22">Shikimic Acid</searchLink><br /><searchLink fieldCode="DE" term="%22Unclassified+Drug%22">Unclassified Drug</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+Cell%22">Animal Cell</searchLink><br /><searchLink fieldCode="DE" term="%22Article%22">Article</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+Activation%22">Cell Activation</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+Study%22">Controlled Study</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8? biapigenin (7), methyl chlorogenate (8), 5-O-pcoumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. Effects of compounds on whole blood phagocytes activity was found to be with IC50 ranging between 8.0-12.2 ?g/mL. Only compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: Records of Natural Products; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.14551/17572; 210; 219; Q3
– Name: URL
  Label: Availability
  Group: URL
  Data: https://hdl.handle.net/20.500.14551/17572
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: info:eu-repo/semantics/closedAccess
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.3CDE5837
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.3CDE5837
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Hypericum Monbretii Spach.
        Type: general
      – SubjectFull: Il-2 Production
        Type: general
      – SubjectFull: Immunomodulating Inhibitory Activity
        Type: general
      – SubjectFull: Phenolics
        Type: general
      – SubjectFull: Reactive Oxygen Species
        Type: general
      – SubjectFull: T-Cell Proliferation
        Type: general
      – SubjectFull: 5 O 4 Coumaroylquinic Acid
        Type: general
      – SubjectFull: 8'' Biapigenin
        Type: general
      – SubjectFull: Chlorogenic Acid
        Type: general
      – SubjectFull: Hypericum Montbretii Extract
        Type: general
      – SubjectFull: Hyperin
        Type: general
      – SubjectFull: Immunosuppressive Agent
        Type: general
      – SubjectFull: Interleukin 2
        Type: general
      – SubjectFull: Kaempferol
        Type: general
      – SubjectFull: Mangiferin
        Type: general
      – SubjectFull: Methanol
        Type: general
      – SubjectFull: Methyl Chlorogenate
        Type: general
      – SubjectFull: Myricetin 3 Rhamnoside
        Type: general
      – SubjectFull: Phenol Derivative
        Type: general
      – SubjectFull: Phytohemagglutinin
        Type: general
      – SubjectFull: Plant Extract
        Type: general
      – SubjectFull: Quercetin
        Type: general
      – SubjectFull: Quercitrin
        Type: general
      – SubjectFull: Rutoside
        Type: general
      – SubjectFull: Shikimic Acid
        Type: general
      – SubjectFull: Unclassified Drug
        Type: general
      – SubjectFull: Animal Cell
        Type: general
      – SubjectFull: Article
        Type: general
      – SubjectFull: Cell Activation
        Type: general
      – SubjectFull: Controlled Study
        Type: general
    Titles:
      – TitleFull: Immunosupressive phenolic constituents from Hypericum montbretii Spach
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Demirkiran O.
      – PersonEntity:
          Name:
            NameFull: Ahmad Mesaik M.
      – PersonEntity:
          Name:
            NameFull: Beynek H.
      – PersonEntity:
          Name:
            NameFull: Abbaskhan A.
      – PersonEntity:
          Name:
            NameFull: Iqbal Choudhary M.
    IsPartOfRelationships:
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          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-locals
              Value: edsbas
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