Academic Journal

The power of genetic diversity in genome-wide association studies of lipids

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The power of genetic diversity in genome-wide association studies of lipids
Συγγραφείς: Graham S. E., Clarke S. L., Wu K. -H. H., Kanoni S., Zajac G. J. M., Ramdas S., Surakka I., Ntalla I., Vedantam S., Winkler T. W., Locke A. E., Marouli E., Hwang M. Y., Han S., Narita A., Choudhury A., Bentley A. R., Ekoru K., Verma A., Trivedi B., Martin H. C., Hunt K. A., Hui Q., Klarin D., Zhu X., Thorleifsson G., Helgadottir A., Gudbjartsson D. F., Holm H., Olafsson I., Akiyama M., Sakaue S., Terao C., Kanai M., Zhou W., Brumpton B. M., Rasheed H., Ruotsalainen S. E., Havulinna A. S., Veturi Y., Feng Q. P., Rosenthal E. A., Lingren T., Pacheco J. A., Pendergrass S. A., Haessler J., Giulianini F., Bradford Y., Miller J. E., Campbell A., Lin K., Millwood I. Y., Hindy G., Rasheed A., Faul J. D., Zhao W., Weir D. R., Turman C., Huang H., Graff M., Mahajan A., Brown M. R., Zhang W., Yu K., Schmidt E. M., Pandit A., Gustafsson S., Yin X., Luan J., Zhao J. -H., Matsuda F., Jang H. -M., Yoon K., Medina-Gomez C., Pitsillides A., Hottenga J. J., Willemsen G., Wood A. R., Ji Y., Gao Z., Haworth S., Mitchell R. E., Chai J. F., Aadahl M., Yao J., Manichaikul A., Warren H. R., Ramirez J., Bork-Jensen J., Karhus L. L., Goel A., Sabater-Lleal M., Noordam R., Sidore C., Fiorillo E., McDaid A. F., Marques-Vidal P., Wielscher M., Trompet S., Sattar N., Mollehave L. T., Thuesen B. H., Munz M., Zeng L., Huang J., Yang B., Poveda A., Kurbasic A., Lamina C., Forer L., Scholz M., Galesloot T. E., Bradfield J. P., Daw E. W., Zmuda J. M., Mitchell J. S., Fuchsberger C., Christensen H., Brody J. A., Feitosa M. F., Wojczynski M. K., Preuss M., Mangino M., Christofidou P., Verweij N., Benjamins J. W., Engmann J., Kember R. L., Slieker R. C., Lo K. S., Zilhao N. R., Le P., Kleber M. E., Delgado G. E., Huo S., Ikeda D. D., Iha H., Yang J., Liu J., Leonard H. L., Marten J., Schmidt B., Arendt M., Smyth L. J., Canadas-Garre M., Wang C., Nakatochi M., Wong A., Hutri-Kahonen N., Sim X., Xia R., Huerta-Chagoya A., Fernandez-Lopez J. C., Lyssenko V., Ahmed M., Jackson A. U., Irvin M. R., Oldmeadow C., Kim H. -N., Ryu S., Timmers P. R. H. J., Arbeeva L., Dorajoo R., Lange L. A., Chai X., Prasad G., Lores-Motta L., Pauper M., Long J., Li X., Theusch E., Takeuchi F., Spracklen C. N., Loukola A., Bollepalli S., Warner S. C., Wang Y. X., Wei W. B., Nutile T., Ruggiero D., Sung Y. J., Hung Y. -J., Chen S., Liu F., Kentistou K. A., Gorski M., Brumat M., Meidtner K., Bielak L. F., Smith J. A., Hebbar P., Farmaki A. -E., Hofer E., Lin M., Xue C., Zhang J., Concas M. P., Vaccargiu S., van der Most P. J., Pitkanen N., Cade B. E., Lee J., van der Laan S. W., Chitrala K. N., Weiss S., Zimmermann M. E., Lee J. Y., Choi H. S., Nethander M., Freitag-Wolf S., Southam L., Rayner N. W., Wang C. A., Lin S. -Y., Wang J. -S., Couture C., Lyytikainen L. -P., Nikus K., Cuellar-Partida G., Vestergaard H., Hildalgo B., Giannakopoulou O., Cai Q., Obura M. O., van Setten J., Schwander K., Terzikhan N., Shin J. H., Jackson R. D., Reiner A. P., Martin L. W., Chen Z., Li L., Highland H. M., Young K. L., Kawaguchi T., Thiery J., Bis J. C., Nadkarni G. N., Launer L. J., Li H., Nalls M. A., Raitakari O. T., Ichihara S., Wild S. H., Nelson C. P., Campbell H., Jager S., Nabika T., Al-Mulla F., Niinikoski H., Braund P. S., Kolcic I., Kovacs P., Giardoglou T., Katsuya T., Bhatti K. F., de Kleijn D., de Borst G. J., Kim E. K., Adams H. H. H., Ikram M. A., Asselbergs F. W., Kraaijeveld A. O., Beulens J. W. J., Shu X. -O., Rallidis L. S., Pedersen O., Hansen T., Mitchell P., Hewitt A. W., Kahonen M., Perusse L., Bouchard C., Tonjes A., Chen Y. -D. I., Pennell C. E., Mori T. A., Lieb W., Franke A., Ohlsson C., Mellstrom D., Cho Y. S., Lee H., Yuan J. -M., Koh W. -P., Rhee S. Y., Woo J. -T., Heid I. M., Stark K. J., Volzke H., Homuth G., Evans M. K., Zonderman A. B., Polasek O., Pasterkamp G., Hoefer I. E., Redline S., Pahkala K., Oldehinkel A. J., Snieder H., Biino G., Schmidt R., Schmidt H., Chen Y. E., Bandinelli S., Dedoussis G., Thanaraj T. A., Kardia S. L. R., Kato N., Schulze M. B., Girotto G., Jung B., Boger C. A., Joshi P. K., Bennett D. A., De Jager P. L., Lu X., Mamakou V., Brown M., Caulfield M. J., Munroe P. B., Guo X., Ciullo M., Jonas J. B., Samani N. J., Kaprio J., Pajukanta P., Adair L. S., Bechayda S. A., de Silva H. J., Wickremasinghe A. R., Krauss R. M., Wu J. -Y., Zheng W., den Hollander A. I., Bharadwaj D., Correa A., Wilson J. G., Lind L., Heng C. -K., Nelson A. E., Golightly Y. M., Wilson J. F., Penninx B., Kim H. -L., Attia J., Scott R. J., Rao D. C., Arnett D. K., Walker M., Koistinen H. A., Chandak G. R., Yajnik C. S., Mercader J. M., Tusie-Luna T., Aguilar-Salinas C. A., Villalpando C. G., Orozco L., Fornage M., Tai E. S., van Dam R. M., Lehtimaki T., Chaturvedi N., Yokota M., Reilly D. F., McKnight A. J., Kee F., Jockel K. -H., McCarthy M. I., Palmer C. N. A., Vitart V., Hayward C., Simonsick E., van Duijn C. M., Lu F., Qu J., Hishigaki H., Lin X., Marz W., Parra E. J., Cruz M., Gudnason V., Tardif J. -C., Lettre G., 't Hart L. M., Elders P. J. M., Damrauer S. M., Kumari M., Kivimaki M., van der Harst P., Spector T. D., Loos R. J. F., Province M. A., Psaty B. M., Brandslund I., Pramstaller P. P., Christensen K., Ripatti S., Widen E., Hakonarson H., Grant S. F. A., Kiemeney L. A. L. M., de Graaf J., Loeffler M., Kronenberg F., Gu D., Erdmann J., Schunkert H., Franks P. W., Linneberg A., Jukema J. W., Khera A. V., Mannikko M., Jarvelin M. -R., Kutalik Z., Cucca F., Mook-Kanamori D. O., van Dijk K. W., Watkins H., Strachan D. P., Grarup N., Sever P., Poulter N., Rotter J. I., Dantoft T. M., Karpe F., Neville M. J., Timpson N. J., Cheng C. -Y., Wong T. -Y., Khor C. C., Sabanayagam C., Peters A., Gieger C., Hattersley A. T., Pedersen N. L., Magnusson P. K. E., Boomsma D. I., de Geus E. J. C., Cupples L. A., van Meurs J. B. J., Ghanbari M., Gordon-Larsen P., Huang W., Kim Y. J., Tabara Y., Wareham N. J., Langenberg C., Zeggini E., Kuusisto J., Laakso M., Ingelsson E., Abecasis G., Chambers J. C., Kooner J. S., de Vries P. S., Morrison A. C., North K. E., Daviglus M., Kraft P., Martin N. G., Whitfield J. B., Abbas S., Saleheen D., Walters R. G., Holmes M. V., Black C., Smith B. H., Justice A. E., Baras A., Buring J. E., Ridker P. M., Chasman D. I., Kooperberg C., Wei W. -Q., Jarvik G. P., Namjou B., Hayes M. G., Ritchie M. D., Jousilahti P., Salomaa V., Hveem K., Asvold B. O., Kubo M., Kamatani Y., Okada Y., Murakami Y., Thorsteinsdottir U., Stefansson K., Ho Y. -L., Lynch J. A., Rader D. J., Tsao P. S., Chang K. -M., Cho K., O'Donnell C. J., Gaziano J. M., Wilson P., Rotimi C. N., Hazelhurst S., Ramsay M., Trembath R. C., van Heel D. A., Tamiya G., Yamamoto M., Kim B. -J., Mohlke K. L., Frayling T. M., Hirschhorn J. N., Kathiresan S., Boehnke M., Natarajan P., Peloso G. M., Brown C. D., Morris A. P., Assimes T. L., Deloukas P., Sun Y. V., Willer C. J.
Συνεισφορές: Graham, S. E., Clarke, S. L., Wu, K. -H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Hwang, M. Y., Han, S., Narita, A., Choudhury, A., Bentley, A. R., Ekoru, K., Verma, A., Trivedi, B., Martin, H. C., Hunt, K. A., Hui, Q., Klarin, D., Zhu, X., Thorleifsson, G., Helgadottir, A., Gudbjartsson, D. F., Holm, H., Olafsson, I., Akiyama, M., Sakaue, S., Terao, C., Kanai, M., Zhou, W., Brumpton, B. M., Rasheed, H., Ruotsalainen, S. E., Havulinna, A. S., Veturi, Y., Feng, Q. P., Rosenthal, E. A., Lingren, T., Pacheco, J. A., Pendergrass, S. A., Haessler, J., Giulianini, F., Bradford, Y., Miller, J. E., Campbell, A., Lin, K., Millwood, I. Y., Hindy, G., Rasheed, A., Faul, J. D., Zhao, W., Weir, D. R., Turman, C., Huang, H., Graff, M., Mahajan, A., Brown, M. R., Zhang, W., Yu, K., Schmidt, E. M., Pandit, A., Gustafsson, S., Yin, X., Luan, J., Zhao, J. -H., Matsuda, F., Jang, H. -M., Yoon, K., Medina-Gomez, C., Pitsillides, A., Hottenga, J. J., Willemsen, G., Wood, A. R., Ji, Y., Gao, Z., Haworth, S., Mitchell, R. E., Chai, J. F., Aadahl, M., Yao, J., Manichaikul, A., Warren, H. R., Ramirez, J., Bork-Jensen, J., Karhus, L. L., Goel, A., Sabater-Lleal, M., Noordam, R., Sidore, C., Fiorillo, E., Mcdaid, A. F., Marques-Vidal, P., Wielscher, M., Trompet, S., Sattar, N.
Έτος έκδοσης: 2021
Συλλογή: Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste)
Θεματικοί όροι: GWAS, blood lipid level, cardiovascular disease
Περιγραφή: Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS4–23 have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns24. Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine25, we anticipate that increased diversity of participants will lead to more accurate and equitable26 application of polygenic scores in clinical practice.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/34887591; info:eu-repo/semantics/altIdentifier/wos/WOS:000728504500001; volume:600; issue:7890; firstpage:675; lastpage:679; numberofpages:5; journal:NATURE; https://hdl.handle.net/11368/3010901
DOI: 10.1038/s41586-021-04064-3
Διαθεσιμότητα: https://hdl.handle.net/11368/3010901
https://doi.org/10.1038/s41586-021-04064-3
https://www.nature.com/articles/s41586-021-04064-3
Rights: info:eu-repo/semantics/openAccess ; license:Copyright Editore ; license:Digital Rights Management non definito
Αριθμός Καταχώρησης: edsbas.3AEE7223
Βάση Δεδομένων: BASE