Dissertation/ Thesis
Development of novel quantitative medical imaging techniques for MPI and MRI
| Τίτλος: | Development of novel quantitative medical imaging techniques for MPI and MRI |
|---|---|
| Συγγραφείς: | Nothnagel, Nils Dennis |
| Συνεισφορές: | Sánchez González, Javier, Ibáñez Cabeza, Borja, Desco Menéndez, Manuel, UC3M. Departamento de Bioingeniería e Ingeniería Aeroespacial |
| Έτος έκδοσης: | 2016 |
| Συλλογή: | Universidad Carlos III de Madrid: e-Archivo |
| Θεματικοί όροι: | Medical imaging techniques, Cardiac imaging, Magnetic resonance imaging, MRI, Very fast 3D breath-hold isotropic imaging using spatio-temporal acceleration, VF 3D-BRISA, Magnetic particle imaging, MPI, Electrónica, Medicina |
| Περιγραφή: | Tomographic imaging has become indispensable in the clinical routine. In a tomographic scan, images of the inner human body are produced without the need of dissecting the human skin. The common types of medical images are two-dimensional slices and entire three-dimensional volumes. To image dynamic processes such as organ function or perfusion, time series are produced at multiple spatial locations. To date, the most common medical imaging modalities are X-ray imaging, Computed Tomography (CT), Magnetic Resonance Imaging (MRI) or tracer-based imaging such as Positron-Emission Tomography (PET) or Single-Photon Emission Tomography (SPECT). Next to the common modalities, a novel medical imaging modality called Magnetic Particle Imaging (MPI) has been introduced, and its position between the established modalities still needs to be defined. In general, cardiovascular applications impose specific challenges on medical imaging. Imaging speed is required to compensate for respiratory and cardiac motions, and to capture rapid uptake rates of contrast agents in the heart tissue. At the same time, high spatial resolution is demanded to accurately assess cardiac anatomy. In this work, we focus on two main cardiovascular applications: cardiac perfusion imaging and cardiac function imaging. Each imaging modality stands out with particular advantages and drawbacks for cardiovascular imaging. Magnetic Resonance Imaging (MRI), for example, has its main advantage in the use of non-ionizing radiation and its superb soft-tissue contrast and is hence suitable for cardiac function assessment. However, due to non-linearity of the MR signal with the contrast concentration, an application such as cardiac perfusion imaging is challenging and requires complex mathematical and practical treatment to measure the arterial input function. A more adequate tool for application on perfusion imaging would be Magnetic Particle Imaging (MPI) since its signal is linear with the contrast concentration over a wide range of concentration. Yet, a ... |
| Τύπος εγγράφου: | doctoral or postdoctoral thesis |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| Relation: | http://hdl.handle.net/10016/23851 |
| Διαθεσιμότητα: | http://hdl.handle.net/10016/23851 |
| Rights: | Atribución-NoComercial-SinDerivadas 3.0 España ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; open access |
| Αριθμός Καταχώρησης: | edsbas.350182A1 |
| Βάση Δεδομένων: | BASE |
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