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Type 2 diabetes and age-related cognitive decline over 40 years in Danish men-A cohort study based on the Danish Aging and Cognition (DanACo) cohort

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Τίτλος: Type 2 diabetes and age-related cognitive decline over 40 years in Danish men-A cohort study based on the Danish Aging and Cognition (DanACo) cohort
Συγγραφείς: Okholm, Gunhild Tidemann, Grønkjær, Marie, Rungby, Jørgen, Mortensen, Erik Lykke, Osler, Merete
Πηγή: Okholm , G T , Grønkjær , M , Rungby , J , Mortensen , E L & Osler , M 2026 , ' Type 2 diabetes and age-related cognitive decline over 40 years in Danish men-A cohort study based on the Danish Aging and Cognition (DanACo) cohort ' , PLoS ONE , vol. 21 , no. 1 , e0340622 . https://doi.org/10.1371/journal.pone.0340622
Έτος έκδοσης: 2026
Συλλογή: University of Copenhagen: Research / Forskning ved Københavns Universitet
Θεματικοί όροι: Humans, Diabetes Mellitus, Type 2/complications, Male, Middle Aged, Denmark/epidemiology, Cohort Studies, Aged, Cognitive Dysfunction/epidemiology, Cognition, Aging, Adult, Intelligence Tests, Follow-Up Studies
Περιγραφή: AIM: The extant literature on type 2 diabetes and cognitive decline is based on short cognitive follow-ups and assessments of baseline cognitive ability after diagnosis. The objective was to investigate the influence of type 2 diabetes on cognitive decline over a period of on average 44 years. MATERIALS AND METHODS: This cohort study included 5,147 men from the Danish Aging and Cognition cohort consisting of a late mid-life (mean age 64.2 years) follow-up of men with intelligence test scores (IQ) available from statutory conscription board examinations in young adulthood (mean age 20.4 years). Follow-up included re-administration of the conscription board intelligence test and a comprehensive questionnaire. Exposure was self-reported but register-based type 2 diabetes and duration of disease were also calculated. Cognitive decline was defined as both IQ change (baseline-follow-up) and significant IQ decline based on the reliable change index (cut-off: 13.2 IQ-points). Associations were analyzed in linear and logistic regression models. RESULTS: Men having type 2 diabetes had a 1.81 IQ points (95%CI:1.14,2.49) larger decline compared to men without diabetes when adjusting for baseline IQ, years of education, follow-up age, retest interval, depression, and smoking status. Moreover, type 2 diabetes was associated with 1.42 times higher odds of a significant IQ decline and longer duration was associated with a larger, though not statistically significant, decline. The participation rate was 13.4%, and the participants were healthier and more well-educated than non-participants. To account for potential selection bias, inverse probability weights (IPW) were calculated based on baseline characteristics. The analyses applying these weights yielded similar estimates. CONCLUSION: Type 2 diabetes was associated with modestly greater cognitive decline and higher odds of a statistically significant (>13.2 IQ points) and clinically relevant decline. Finally, the alignment between main and IPW results indicates the ...
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
DOI: 10.1371/journal.pone.0340622
Διαθεσιμότητα: https://researchprofiles.ku.dk/da/publications/bdc850aa-7a9b-4ed7-ba61-caeffc71d12f
https://doi.org/10.1371/journal.pone.0340622
https://curis.ku.dk/ws/files/531394153/journal.pone.0340622.pdf
Rights: info:eu-repo/semantics/openAccess
Αριθμός Καταχώρησης: edsbas.2FD7B4E8
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  Data: Type 2 diabetes and age-related cognitive decline over 40 years in Danish men-A cohort study based on the Danish Aging and Cognition (DanACo) cohort
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  Data: <searchLink fieldCode="AR" term="%22Okholm%2C+Gunhild+Tidemann%22">Okholm, Gunhild Tidemann</searchLink><br /><searchLink fieldCode="AR" term="%22Grønkjær%2C+Marie%22">Grønkjær, Marie</searchLink><br /><searchLink fieldCode="AR" term="%22Rungby%2C+Jørgen%22">Rungby, Jørgen</searchLink><br /><searchLink fieldCode="AR" term="%22Mortensen%2C+Erik+Lykke%22">Mortensen, Erik Lykke</searchLink><br /><searchLink fieldCode="AR" term="%22Osler%2C+Merete%22">Osler, Merete</searchLink>
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  Data: Okholm , G T , Grønkjær , M , Rungby , J , Mortensen , E L & Osler , M 2026 , ' Type 2 diabetes and age-related cognitive decline over 40 years in Danish men-A cohort study based on the Danish Aging and Cognition (DanACo) cohort ' , PLoS ONE , vol. 21 , no. 1 , e0340622 . https://doi.org/10.1371/journal.pone.0340622
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  Data: University of Copenhagen: Research / Forskning ved Københavns Universitet
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  Data: <searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+Mellitus%22">Diabetes Mellitus</searchLink><br /><searchLink fieldCode="DE" term="%22Type+2%2Fcomplications%22">Type 2/complications</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+Aged%22">Middle Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Denmark%2Fepidemiology%22">Denmark/epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+Studies%22">Cohort Studies</searchLink><br /><searchLink fieldCode="DE" term="%22Aged%22">Aged</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+Dysfunction%2Fepidemiology%22">Cognitive Dysfunction/epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br /><searchLink fieldCode="DE" term="%22Adult%22">Adult</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence+Tests%22">Intelligence Tests</searchLink><br /><searchLink fieldCode="DE" term="%22Follow-Up+Studies%22">Follow-Up Studies</searchLink>
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  Data: AIM: The extant literature on type 2 diabetes and cognitive decline is based on short cognitive follow-ups and assessments of baseline cognitive ability after diagnosis. The objective was to investigate the influence of type 2 diabetes on cognitive decline over a period of on average 44 years. MATERIALS AND METHODS: This cohort study included 5,147 men from the Danish Aging and Cognition cohort consisting of a late mid-life (mean age 64.2 years) follow-up of men with intelligence test scores (IQ) available from statutory conscription board examinations in young adulthood (mean age 20.4 years). Follow-up included re-administration of the conscription board intelligence test and a comprehensive questionnaire. Exposure was self-reported but register-based type 2 diabetes and duration of disease were also calculated. Cognitive decline was defined as both IQ change (baseline-follow-up) and significant IQ decline based on the reliable change index (cut-off: 13.2 IQ-points). Associations were analyzed in linear and logistic regression models. RESULTS: Men having type 2 diabetes had a 1.81 IQ points (95%CI:1.14,2.49) larger decline compared to men without diabetes when adjusting for baseline IQ, years of education, follow-up age, retest interval, depression, and smoking status. Moreover, type 2 diabetes was associated with 1.42 times higher odds of a significant IQ decline and longer duration was associated with a larger, though not statistically significant, decline. The participation rate was 13.4%, and the participants were healthier and more well-educated than non-participants. To account for potential selection bias, inverse probability weights (IPW) were calculated based on baseline characteristics. The analyses applying these weights yielded similar estimates. CONCLUSION: Type 2 diabetes was associated with modestly greater cognitive decline and higher odds of a statistically significant (>13.2 IQ points) and clinically relevant decline. Finally, the alignment between main and IPW results indicates the ...
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        Value: 10.1371/journal.pone.0340622
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    Subjects:
      – SubjectFull: Humans
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