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A Perspective on the Added Value of Red Blood Cells during Cardiac Hypothermic Oxygenated Perfusion

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Τίτλος: A Perspective on the Added Value of Red Blood Cells during Cardiac Hypothermic Oxygenated Perfusion
Συγγραφείς: Vervoorn, Mats T, Ballan, Elisa M, Kaffka Genaamd Dengler, Selma E, Meijborg, Veronique M F, de Jager, Saskia C A, Van Wijk, Richard, van der Kaaij, Niels P, Arts Assistenten CTC, Innovatie CTC, Experimentele Afd. Cardiologie 2, Circulatory Health, Infection & Immunity, CDL Cluster Speciële Diagnostiek, Child Health, Regenerative Medicine and Stem Cells, CTC
Έτος έκδοσης: 2025
Θεματικοί όροι: cardiac HOPE, donor heart preservation, ex-situ heart perfusion, heart transplantation, red blood cells, Taverne, Cardiology and Cardiovascular Medicine, Transplantation, Pulmonary and Respiratory Medicine, Surgery
Περιγραφή: Hypothermic oxygenated perfusion (HOPE) is an emerging technique for donor heart preservation that is currently being studied in multiple clinical trials with promising results. When compared to HOPE for other organs, cardiac protocols involve red blood cell (RBC) supplementation, despite absence of comparative evidence for its benefits. In this perspective paper, we discuss the pros and cons of the addition of RBCs during cardiac HOPE. Although the current clinical results with RBC supplementation during HOPE seem promising, potential downsides of RBC supplementation cannot be ruled out. The impact of supplemented RBCs during cardiac HOPE requires further investigation to improve HOPE protocols, to optimize heart preservation using this promising technology.
Τύπος εγγράφου: other non-article part of journal/newspaper
Περιγραφή αρχείου: text/plain
Γλώσσα: English
ISSN: 1053-2498
Relation: https://dspace.library.uu.nl/handle/1874/458349
Διαθεσιμότητα: https://dspace.library.uu.nl/handle/1874/458349
Rights: info:eu-repo/semantics/OpenAccess
Αριθμός Καταχώρησης: edsbas.2BEB0804
Βάση Δεδομένων: BASE
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  Data: <searchLink fieldCode="AR" term="%22Vervoorn%2C+Mats+T%22">Vervoorn, Mats T</searchLink><br /><searchLink fieldCode="AR" term="%22Ballan%2C+Elisa+M%22">Ballan, Elisa M</searchLink><br /><searchLink fieldCode="AR" term="%22Kaffka+Genaamd+Dengler%2C+Selma+E%22">Kaffka Genaamd Dengler, Selma E</searchLink><br /><searchLink fieldCode="AR" term="%22Meijborg%2C+Veronique+M+F%22">Meijborg, Veronique M F</searchLink><br /><searchLink fieldCode="AR" term="%22de+Jager%2C+Saskia+C+A%22">de Jager, Saskia C A</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Wijk%2C+Richard%22">Van Wijk, Richard</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Kaaij%2C+Niels+P%22">van der Kaaij, Niels P</searchLink><br /><searchLink fieldCode="AR" term="%22Arts+Assistenten+CTC%22">Arts Assistenten CTC</searchLink><br /><searchLink fieldCode="AR" term="%22Innovatie+CTC%22">Innovatie CTC</searchLink><br /><searchLink fieldCode="AR" term="%22Experimentele+Afd%2E+Cardiologie+2%22">Experimentele Afd. Cardiologie 2</searchLink><br /><searchLink fieldCode="AR" term="%22Circulatory+Health%22">Circulatory Health</searchLink><br /><searchLink fieldCode="AR" term="%22Infection+%26+Immunity%22">Infection & Immunity</searchLink><br /><searchLink fieldCode="AR" term="%22CDL+Cluster+Speciële+Diagnostiek%22">CDL Cluster Speciële Diagnostiek</searchLink><br /><searchLink fieldCode="AR" term="%22Child+Health%22">Child Health</searchLink><br /><searchLink fieldCode="AR" term="%22Regenerative+Medicine+and+Stem+Cells%22">Regenerative Medicine and Stem Cells</searchLink><br /><searchLink fieldCode="AR" term="%22CTC%22">CTC</searchLink>
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  Data: 2025
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  Data: <searchLink fieldCode="DE" term="%22cardiac+HOPE%22">cardiac HOPE</searchLink><br /><searchLink fieldCode="DE" term="%22donor+heart+preservation%22">donor heart preservation</searchLink><br /><searchLink fieldCode="DE" term="%22ex-situ+heart+perfusion%22">ex-situ heart perfusion</searchLink><br /><searchLink fieldCode="DE" term="%22heart+transplantation%22">heart transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22red+blood+cells%22">red blood cells</searchLink><br /><searchLink fieldCode="DE" term="%22Taverne%22">Taverne</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiology+and+Cardiovascular+Medicine%22">Cardiology and Cardiovascular Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Transplantation%22">Transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+and+Respiratory+Medicine%22">Pulmonary and Respiratory Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink>
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  Data: Hypothermic oxygenated perfusion (HOPE) is an emerging technique for donor heart preservation that is currently being studied in multiple clinical trials with promising results. When compared to HOPE for other organs, cardiac protocols involve red blood cell (RBC) supplementation, despite absence of comparative evidence for its benefits. In this perspective paper, we discuss the pros and cons of the addition of RBCs during cardiac HOPE. Although the current clinical results with RBC supplementation during HOPE seem promising, potential downsides of RBC supplementation cannot be ruled out. The impact of supplemented RBCs during cardiac HOPE requires further investigation to improve HOPE protocols, to optimize heart preservation using this promising technology.
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      – SubjectFull: cardiac HOPE
        Type: general
      – SubjectFull: donor heart preservation
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      – SubjectFull: ex-situ heart perfusion
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      – SubjectFull: heart transplantation
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