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The relationship between alcohol use and dementia in adults aged more than 60 years : a combined analysis of prospective, individual-participant data from 15 international studies

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Τίτλος: The relationship between alcohol use and dementia in adults aged more than 60 years : a combined analysis of prospective, individual-participant data from 15 international studies
Συγγραφείς: Mewton, L., Visontay, R., Hoy, N., Lipnicki, D., Sunderland, M., Lipton, R.B., Guerchet, Maëlenn, Ritchie, K., Najar, J., Scarmeas, N., Kim, K.W., Riedel Heller, S., van Boxtel, M., Jacobsen, E., Brodaty, H., Anstey, K.J., Haan, M., Scazufca, M., Lobo, E., Sachdev, P.S.
Συνεισφορές: Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), Institut de Recherche pour le Développement (IRD)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)
Πηγή: ISSN: 0965-2140.
Στοιχεία εκδότη: CCSD
Wiley
Έτος έκδοσης: 2022
Συλλογή: Inserm: HAL (Institut national de la santé et de la recherche médicale)
Θεματικοί όροι: AUSTRALIE, BRESIL, COREE DU SUD, PAYS BAS, ALLEMAGNE, GRECE, SUEDE, ESPAGNE, FRANCE, ETATS UNIS, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Περιγραφή: Aim : To synthesize international findings on the alcohol-dementia relationship, including representation from low and middle income countries. Methods : Individual participant data meta analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. Cox regression investigated the dementia risk associated with alcohol use in older adults aged over 60 years. Additional analyses assessed the alcohol-dementia relationship in the sample stratified by sex and by continent. Participants included 24 478 community dwelling individuals without a history of dementia at baseline and at least one follow up dementia assessment. The main outcome measure was all cause dementia as determined by clinical interview.Results : At baseline, the mean age across studies was 71.8 (standard deviation = 7.5, range = 60-102 years), 14 260 (58.3%) were female and 13 269 (54.2%) were current drinkers. During 151 636 person years of follow up, there were 2124 incident cases of dementia (14.0 per 1000 person years). When compared with abstainers, the risk for dementia was lower in occasional [hazard ratio (HR) = 0.78; 95% confidence interval (CI) = 0.68-0.89], light-moderate (HR = 0.78; 95% CI = 0.70-0.87) and moderate-heavy drinkers (HR = 0.62; 95% CI = 0.51-0.77). There was no evidence of differences between life time abstainers and former drinkers in terms of dementia risk (HR = 0.98; 95% CI = 0.81-1.18). In dose-response analyses, moderate drinking up to 40 g/day was associated with a lower risk of dementia when compared with lifetime abstaining. Among current drinkers, there was no consistent evidence for differences in terms of dementia risk. Results were similar when the sample was stratified by sex. When analysed at the continent level, there was considerable heterogeneity in the alcohol-dementia relationship. Conclusions : Abstinence from alcohol appears to be associated with an increased risk for all cause dementia. Among current drinkers, there appears to be no consistent evidence to suggest ...
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
Relation: IRD: fdi:010089018
DOI: 10.1111/add.16035
Διαθεσιμότητα: https://hal.science/hal-04330567
https://hal.science/hal-04330567v1/document
https://hal.science/hal-04330567v1/file/texto_completo.pdf
https://doi.org/10.1111/add.16035
Rights: https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess
Αριθμός Καταχώρησης: edsbas.2709DA3D
Βάση Δεδομένων: BASE
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  Data: The relationship between alcohol use and dementia in adults aged more than 60 years : a combined analysis of prospective, individual-participant data from 15 international studies
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  Data: <searchLink fieldCode="AR" term="%22Mewton%2C+L%2E%22">Mewton, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Visontay%2C+R%2E%22">Visontay, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Hoy%2C+N%2E%22">Hoy, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Lipnicki%2C+D%2E%22">Lipnicki, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Sunderland%2C+M%2E%22">Sunderland, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lipton%2C+R%2EB%2E%22">Lipton, R.B.</searchLink><br /><searchLink fieldCode="AR" term="%22Guerchet%2C+Maëlenn%22">Guerchet, Maëlenn</searchLink><br /><searchLink fieldCode="AR" term="%22Ritchie%2C+K%2E%22">Ritchie, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Najar%2C+J%2E%22">Najar, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Scarmeas%2C+N%2E%22">Scarmeas, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+K%2EW%2E%22">Kim, K.W.</searchLink><br /><searchLink fieldCode="AR" term="%22Riedel+Heller%2C+S%2E%22">Riedel Heller, S.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Boxtel%2C+M%2E%22">van Boxtel, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Jacobsen%2C+E%2E%22">Jacobsen, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Brodaty%2C+H%2E%22">Brodaty, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Anstey%2C+K%2EJ%2E%22">Anstey, K.J.</searchLink><br /><searchLink fieldCode="AR" term="%22Haan%2C+M%2E%22">Haan, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Scazufca%2C+M%2E%22">Scazufca, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lobo%2C+E%2E%22">Lobo, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Sachdev%2C+P%2ES%2E%22">Sachdev, P.S.</searchLink>
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  Data: Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT)<br />Institut de Recherche pour le Développement (IRD)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth)<br />Université de Limoges (UNILIM)-Université de Limoges (UNILIM)
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  Data: <i>ISSN: 0965-2140</i>.
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  Data: 2022
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  Data: Inserm: HAL (Institut national de la santé et de la recherche médicale)
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  Data: Aim : To synthesize international findings on the alcohol-dementia relationship, including representation from low and middle income countries. Methods : Individual participant data meta analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. Cox regression investigated the dementia risk associated with alcohol use in older adults aged over 60 years. Additional analyses assessed the alcohol-dementia relationship in the sample stratified by sex and by continent. Participants included 24 478 community dwelling individuals without a history of dementia at baseline and at least one follow up dementia assessment. The main outcome measure was all cause dementia as determined by clinical interview.Results : At baseline, the mean age across studies was 71.8 (standard deviation = 7.5, range = 60-102 years), 14 260 (58.3%) were female and 13 269 (54.2%) were current drinkers. During 151 636 person years of follow up, there were 2124 incident cases of dementia (14.0 per 1000 person years). When compared with abstainers, the risk for dementia was lower in occasional [hazard ratio (HR) = 0.78; 95% confidence interval (CI) = 0.68-0.89], light-moderate (HR = 0.78; 95% CI = 0.70-0.87) and moderate-heavy drinkers (HR = 0.62; 95% CI = 0.51-0.77). There was no evidence of differences between life time abstainers and former drinkers in terms of dementia risk (HR = 0.98; 95% CI = 0.81-1.18). In dose-response analyses, moderate drinking up to 40 g/day was associated with a lower risk of dementia when compared with lifetime abstaining. Among current drinkers, there was no consistent evidence for differences in terms of dementia risk. Results were similar when the sample was stratified by sex. When analysed at the continent level, there was considerable heterogeneity in the alcohol-dementia relationship. Conclusions : Abstinence from alcohol appears to be associated with an increased risk for all cause dementia. Among current drinkers, there appears to be no consistent evidence to suggest ...
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