Academic Journal
Προβολή σε EDS

Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)
Συγγραφείς: Shah, Dilip, Das, Pragnya, Acharya, Suchismita, Agarwal, Beamon, Christensen, Dale J., Robertson, Stella M., Bhandari, Vineet
Πηγή: International Journal of Molecular Sciences
Στοιχεία εκδότη: MDPI
Έτος έκδοσης: 2022
Συλλογή: UNTHSC Scholarly Repository (University. of North Texas Health Science Center)
Θεματικοί όροι: Avr-25, Avr-48, acute lung injury, lung inflammation, pulmonary edema, sepsis, Acute Lung Injury / drug therapy, Animals, Chitin / pharmacology, Disease Models, Animal, Female, Immunologic Factors / pharmacology, Lipopolysaccharides / pharmacology, Lung / drug effects, Male, Mice, Inbred C57BL, Pneumonia / drug therapy, Pulmonary Edema / drug therapy, Rats, Sprague-Dawley, Respiratory Distress Syndrome / drug therapy, Sepsis / drug therapy, Small Molecule Libraries / pharmacology
Περιγραφή: BACKGROUND: Acute lung injury (ALI) or its most advanced form, acute respiratory distress syndrome (ARDS) is a severe inflammatory pulmonary process triggered by a variety of insults including sepsis, viral or bacterial pneumonia, and mechanical ventilator-induced trauma. Currently, there are no effective therapies available for ARDS. We have recently reported that a novel small molecule AVR-25 derived from chitin molecule (a long-chain polymer of N-acetylglucosamine) showed anti-inflammatory effects in the lungs. The goal of this study was to determine the efficacy of two chitin-derived compounds, AVR-25 and AVR-48, in multiple mouse models of ALI/ARDS. We further determined the safety and pharmacokinetic (PK) profile of the lead compound AVR-48 in rats. METHODS: ALI in mice was induced by intratracheal instillation of a single dose of lipopolysaccharide (LPS; 100 µg) for 24 h or exposed to hyperoxia (100% oxygen) for 48 h or undergoing cecal ligation and puncture (CLP) procedure and observation for 10 days. RESULTS: Both chitin derivatives, AVR-25 and AVR-48, showed decreased neutrophil recruitment and reduced inflammation in the lungs of ALI mice. Further, AVR-25 and AVR-48 mediated diminished lung inflammation was associated with reduced expression of lung adhesion molecules with improvement in pulmonary endothelial barrier function, pulmonary edema, and lung injury. Consistent with these results, CLP-induced sepsis mice treated with AVR-48 showed a significant increase in survival of the mice (80%) and improved lung histopathology in the treated CLP group. AVR-48, the lead chitin derivative compound, demonstrated a good safety profile. CONCLUSION: Both AVR-25 and AVR-48 demonstrate the potential to be developed as therapeutic agents to treat ALI/ARDS. ; This research was funded, in part, by a research contract received from AyuVis Research Inc.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: application/pdf
Γλώσσα: unknown
Relation: https://doi.org/10.3390/ijms22052573; Shah, D., Das, P., Acharya, S., Agarwal, B., Christensen, D. J., Robertson, S. M., & Bhandari, V. (2021). Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). International journal of molecular sciences, 22(5), 2573. https://doi.org/10.3390/ijms22052573; https://hdl.handle.net/20.500.12503/31592; 22
Διαθεσιμότητα: https://hdl.handle.net/20.500.12503/31592
Rights: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ ; © 2021 by the authors.
Αριθμός Καταχώρησης: edsbas.256BDB8
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://hdl.handle.net/20.500.12503/31592#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.256BDB8
RelevancyScore: 920
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 920.2763671875
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Shah%2C+Dilip%22">Shah, Dilip</searchLink><br /><searchLink fieldCode="AR" term="%22Das%2C+Pragnya%22">Das, Pragnya</searchLink><br /><searchLink fieldCode="AR" term="%22Acharya%2C+Suchismita%22">Acharya, Suchismita</searchLink><br /><searchLink fieldCode="AR" term="%22Agarwal%2C+Beamon%22">Agarwal, Beamon</searchLink><br /><searchLink fieldCode="AR" term="%22Christensen%2C+Dale+J%2E%22">Christensen, Dale J.</searchLink><br /><searchLink fieldCode="AR" term="%22Robertson%2C+Stella+M%2E%22">Robertson, Stella M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bhandari%2C+Vineet%22">Bhandari, Vineet</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: International Journal of Molecular Sciences
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: MDPI
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2022
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: UNTHSC Scholarly Repository (University. of North Texas Health Science Center)
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Avr-25%22">Avr-25</searchLink><br /><searchLink fieldCode="DE" term="%22Avr-48%22">Avr-48</searchLink><br /><searchLink fieldCode="DE" term="%22acute+lung+injury%22">acute lung injury</searchLink><br /><searchLink fieldCode="DE" term="%22lung+inflammation%22">lung inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22pulmonary+edema%22">pulmonary edema</searchLink><br /><searchLink fieldCode="DE" term="%22sepsis%22">sepsis</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+Lung+Injury+%2F+drug+therapy%22">Acute Lung Injury / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Chitin+%2F+pharmacology%22">Chitin / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+Models%22">Disease Models</searchLink><br /><searchLink fieldCode="DE" term="%22Animal%22">Animal</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+Factors+%2F+pharmacology%22">Immunologic Factors / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Lipopolysaccharides+%2F+pharmacology%22">Lipopolysaccharides / pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+%2F+drug+effects%22">Lung / drug effects</searchLink><br /><searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Inbred+C57BL%22">Inbred C57BL</searchLink><br /><searchLink fieldCode="DE" term="%22Pneumonia+%2F+drug+therapy%22">Pneumonia / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+Edema+%2F+drug+therapy%22">Pulmonary Edema / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Sprague-Dawley%22">Sprague-Dawley</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+Distress+Syndrome+%2F+drug+therapy%22">Respiratory Distress Syndrome / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Sepsis+%2F+drug+therapy%22">Sepsis / drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Small+Molecule+Libraries+%2F+pharmacology%22">Small Molecule Libraries / pharmacology</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: BACKGROUND: Acute lung injury (ALI) or its most advanced form, acute respiratory distress syndrome (ARDS) is a severe inflammatory pulmonary process triggered by a variety of insults including sepsis, viral or bacterial pneumonia, and mechanical ventilator-induced trauma. Currently, there are no effective therapies available for ARDS. We have recently reported that a novel small molecule AVR-25 derived from chitin molecule (a long-chain polymer of N-acetylglucosamine) showed anti-inflammatory effects in the lungs. The goal of this study was to determine the efficacy of two chitin-derived compounds, AVR-25 and AVR-48, in multiple mouse models of ALI/ARDS. We further determined the safety and pharmacokinetic (PK) profile of the lead compound AVR-48 in rats. METHODS: ALI in mice was induced by intratracheal instillation of a single dose of lipopolysaccharide (LPS; 100 µg) for 24 h or exposed to hyperoxia (100% oxygen) for 48 h or undergoing cecal ligation and puncture (CLP) procedure and observation for 10 days. RESULTS: Both chitin derivatives, AVR-25 and AVR-48, showed decreased neutrophil recruitment and reduced inflammation in the lungs of ALI mice. Further, AVR-25 and AVR-48 mediated diminished lung inflammation was associated with reduced expression of lung adhesion molecules with improvement in pulmonary endothelial barrier function, pulmonary edema, and lung injury. Consistent with these results, CLP-induced sepsis mice treated with AVR-48 showed a significant increase in survival of the mice (80%) and improved lung histopathology in the treated CLP group. AVR-48, the lead chitin derivative compound, demonstrated a good safety profile. CONCLUSION: Both AVR-25 and AVR-48 demonstrate the potential to be developed as therapeutic agents to treat ALI/ARDS. ; This research was funded, in part, by a research contract received from AyuVis Research Inc.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: application/pdf
– Name: Language
  Label: Language
  Group: Lang
  Data: unknown
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: https://doi.org/10.3390/ijms22052573; Shah, D., Das, P., Acharya, S., Agarwal, B., Christensen, D. J., Robertson, S. M., & Bhandari, V. (2021). Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). International journal of molecular sciences, 22(5), 2573. https://doi.org/10.3390/ijms22052573; https://hdl.handle.net/20.500.12503/31592; 22
– Name: URL
  Label: Availability
  Group: URL
  Data: https://hdl.handle.net/20.500.12503/31592
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/ ; © 2021 by the authors.
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.256BDB8
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.256BDB8
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Text: unknown
    Subjects:
      – SubjectFull: Avr-25
        Type: general
      – SubjectFull: Avr-48
        Type: general
      – SubjectFull: acute lung injury
        Type: general
      – SubjectFull: lung inflammation
        Type: general
      – SubjectFull: pulmonary edema
        Type: general
      – SubjectFull: sepsis
        Type: general
      – SubjectFull: Acute Lung Injury / drug therapy
        Type: general
      – SubjectFull: Animals
        Type: general
      – SubjectFull: Chitin / pharmacology
        Type: general
      – SubjectFull: Disease Models
        Type: general
      – SubjectFull: Animal
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Immunologic Factors / pharmacology
        Type: general
      – SubjectFull: Lipopolysaccharides / pharmacology
        Type: general
      – SubjectFull: Lung / drug effects
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Mice
        Type: general
      – SubjectFull: Inbred C57BL
        Type: general
      – SubjectFull: Pneumonia / drug therapy
        Type: general
      – SubjectFull: Pulmonary Edema / drug therapy
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Sprague-Dawley
        Type: general
      – SubjectFull: Respiratory Distress Syndrome / drug therapy
        Type: general
      – SubjectFull: Sepsis / drug therapy
        Type: general
      – SubjectFull: Small Molecule Libraries / pharmacology
        Type: general
    Titles:
      – TitleFull: Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Shah, Dilip
      – PersonEntity:
          Name:
            NameFull: Das, Pragnya
      – PersonEntity:
          Name:
            NameFull: Acharya, Suchismita
      – PersonEntity:
          Name:
            NameFull: Agarwal, Beamon
      – PersonEntity:
          Name:
            NameFull: Christensen, Dale J.
      – PersonEntity:
          Name:
            NameFull: Robertson, Stella M.
      – PersonEntity:
          Name:
            NameFull: Bhandari, Vineet
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
          Titles:
            – TitleFull: International Journal of Molecular Sciences
              Type: main
ResultId 1