Academic Journal
Absence of mutations in the human OB gene in obese diabetic subjects
| Τίτλος: | Absence of mutations in the human OB gene in obese diabetic subjects |
|---|---|
| Συγγραφείς: | Maffei, M, Stoffel, M, Barone, M, Moon, B, Dammerman, M, Ravussin, E, Bogardus, C, Ludwig, DS, Flier, JS, Talley, M, Auerbach, S, Friedman, JM |
| Πηγή: | Diabetes (N.Y.N.Y.) 45 (1996): 679–682. doi:10.2337/diabetes.45.5.679 ; info:cnr-pdr/source/autori:Maffei, M; Stoffel, M; Barone, M; Moon, B; Dammerman, M; Ravussin, E; Bogardus, C; Ludwig, DS; Flier, JS; Talley, M; Auerbach, S; Friedman, JM/titolo:Absence of mutations in the human OB gene in obese diabetic subjects/doi:10.2337diabetes.45.5.679/rivista:Diabetes (N.Y.N.Y.)/anno:1996/pagina_da:679/pagina_a:682/intervallo_pagine:679–682/volume:45 |
| Στοιχεία εκδότη: | American Diabetes Association], [New York,, Stati Uniti d'America |
| Έτος έκδοσης: | 1996 |
| Συλλογή: | PUMAlab (ISTI CNR - Consiglio Nazionale delle Ricerche / National Research Council) |
| Περιγραφή: | The product of the obese (ob) gene, leptin, is a secreted protein that is important in the regulation of body weight. Mice with mutations in the ob gene are obese and diabetic and manifest reduced physical as well as metabolic activity. In this study, we tested the possibility that mutations tin the OB gene may contribute to human obesity, We report the isolation and partial sequence of the human OB gene and the screening of 105 obese patients for mutations in the protein coding sequence using the technique of single-strand conformational polymorphism. No coding sequence polymorphism was found, suggesting that mutations in the coding sequence of the OB gene do not constitute a common cause of increased body weight in humans, We also identified a highly polymorphic simple dinucleotide repeat DNA polymorphism in this gene that will be useful for genetic studies. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| Relation: | info:cnr-pdr/author/matricola:11486/MAFFEI/MARGHERITA; http://www.cnr.it/prodotto/i/317990; https://publications.cnr.it/doc/317990; https://dx.doi.org/10.2337/diabetes.45.5.679; info:doi:10.2337/diabetes.45.5.679 |
| DOI: | 10.2337/diabetes.45.5.679 |
| Διαθεσιμότητα: | http://www.cnr.it/prodotto/i/317990 https://publications.cnr.it/doc/317990 https://doi.org/10.2337/diabetes.45.5.679 |
| Αριθμός Καταχώρησης: | edsbas.1F3E31D2 |
| Βάση Δεδομένων: | BASE |
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