Academic Journal
Προβολή σε EDS

Cannabinoids in integumentary wound care : a systematic review of emerging preclinical and clinical evidence

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Cannabinoids in integumentary wound care : a systematic review of emerging preclinical and clinical evidence
Συγγραφείς: Niyangoda, D., Muayad, M., Tesfaye, W., Bushell, M., Ahmad, D., Samarawickrema, I., Sinclair, Justin (R19074), Kebriti, S., Maida, V., Thomas, J.
Στοιχεία εκδότη: Switzerland, MDPI
Έτος έκδοσης: 2024
Συλλογή: University of Western Sydney (UWS): Research Direct
Θεματικοί όροι: XXXXXX - Unknown
Περιγραφή: This systematic review critically evaluates preclinical and clinical data on the antibacterial and wound healing properties of cannabinoids in integument wounds. Comprehensive searches were conducted across multiple databases, including CINAHL, Cochrane library, Medline, Embase, PubMed, Web of Science, and LILACS, encompassing records up to May 22, 2024. Eighteen studies met the inclusion criteria. Eleven were animal studies, predominantly utilizing murine models (n = 10) and one equine model, involving 437 animals. The seven human studies ranged from case reports to randomized controlled trials, encompassing 92 participants aged six months to ninety years, with sample sizes varying from 1 to 69 patients. The studies examined the effects of various cannabinoid formulations, including combinations with other plant extracts, crude extracts, and purified and synthetic cannabis-based medications administered topically, intraperitoneally, orally, or sublingually. Four animal and three human studies reported complete wound closure. Hemp fruit oil extract, cannabidiol (CBD), and GP1a resulted in complete wound closure in twenty-three (range: 5–84) days with a healing rate of 66–86% within ten days in animal studies. One human study documented a wound healing rate of 3.3 cm2 over 30 days, while three studies on chronic, non-healing wounds reported an average healing time of 54 (21–150) days for 17 patients by oral oils with tetrahydrocannabinol (THC) and CBD and topical gels with THC, CBD, and terpenes. CBD and tetrahydrocannabidiol demonstrated significant potential in reducing bacterial loads in murine models. However, further high-quality research is imperative to fully elucidate the therapeutic potential of cannabinoids in the treatment of bacterial skin infections and wounds. Additionally, it is crucial to delineate the impact of medicinal cannabis on the various phases of wound healing. This study was registered in PROSPERO (CRD42021255413).
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: print
Γλώσσα: English
Relation: Pharmaceutics--1999-4923-- Vol. 16 Issue. 8 No. 1081 pp: -
DOI: 10.3390/pharmaceutics16081081
Διαθεσιμότητα: https://doi.org/10.3390/pharmaceutics16081081
https://hdl.handle.net/1959.7/uws:78908
Rights: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
Αριθμός Καταχώρησης: edsbas.1CE61D29
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://doi.org/10.3390/pharmaceutics16081081#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.1CE61D29
RelevancyScore: 945
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 944.983581542969
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cannabinoids in integumentary wound care : a systematic review of emerging preclinical and clinical evidence
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Niyangoda%2C+D%2E%22">Niyangoda, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Muayad%2C+M%2E%22">Muayad, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tesfaye%2C+W%2E%22">Tesfaye, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Bushell%2C+M%2E%22">Bushell, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ahmad%2C+D%2E%22">Ahmad, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Samarawickrema%2C+I%2E%22">Samarawickrema, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Sinclair%2C+Justin+%28R19074%29%22">Sinclair, Justin (R19074)</searchLink><br /><searchLink fieldCode="AR" term="%22Kebriti%2C+S%2E%22">Kebriti, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Maida%2C+V%2E%22">Maida, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Thomas%2C+J%2E%22">Thomas, J.</searchLink>
– Name: Publisher
  Label: Publisher Information
  Group: PubInfo
  Data: Switzerland, MDPI
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2024
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: University of Western Sydney (UWS): Research Direct
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22XXXXXX+-+Unknown%22">XXXXXX - Unknown</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: This systematic review critically evaluates preclinical and clinical data on the antibacterial and wound healing properties of cannabinoids in integument wounds. Comprehensive searches were conducted across multiple databases, including CINAHL, Cochrane library, Medline, Embase, PubMed, Web of Science, and LILACS, encompassing records up to May 22, 2024. Eighteen studies met the inclusion criteria. Eleven were animal studies, predominantly utilizing murine models (n = 10) and one equine model, involving 437 animals. The seven human studies ranged from case reports to randomized controlled trials, encompassing 92 participants aged six months to ninety years, with sample sizes varying from 1 to 69 patients. The studies examined the effects of various cannabinoid formulations, including combinations with other plant extracts, crude extracts, and purified and synthetic cannabis-based medications administered topically, intraperitoneally, orally, or sublingually. Four animal and three human studies reported complete wound closure. Hemp fruit oil extract, cannabidiol (CBD), and GP1a resulted in complete wound closure in twenty-three (range: 5–84) days with a healing rate of 66–86% within ten days in animal studies. One human study documented a wound healing rate of 3.3 cm2 over 30 days, while three studies on chronic, non-healing wounds reported an average healing time of 54 (21–150) days for 17 patients by oral oils with tetrahydrocannabinol (THC) and CBD and topical gels with THC, CBD, and terpenes. CBD and tetrahydrocannabidiol demonstrated significant potential in reducing bacterial loads in murine models. However, further high-quality research is imperative to fully elucidate the therapeutic potential of cannabinoids in the treatment of bacterial skin infections and wounds. Additionally, it is crucial to delineate the impact of medicinal cannabis on the various phases of wound healing. This study was registered in PROSPERO (CRD42021255413).
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: print
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: Pharmaceutics--1999-4923-- Vol. 16 Issue. 8 No. 1081 pp: -
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.3390/pharmaceutics16081081
– Name: URL
  Label: Availability
  Group: URL
  Data: https://doi.org/10.3390/pharmaceutics16081081<br />https://hdl.handle.net/1959.7/uws:78908
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.1CE61D29
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.1CE61D29
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3390/pharmaceutics16081081
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: XXXXXX - Unknown
        Type: general
    Titles:
      – TitleFull: Cannabinoids in integumentary wound care : a systematic review of emerging preclinical and clinical evidence
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Niyangoda, D.
      – PersonEntity:
          Name:
            NameFull: Muayad, M.
      – PersonEntity:
          Name:
            NameFull: Tesfaye, W.
      – PersonEntity:
          Name:
            NameFull: Bushell, M.
      – PersonEntity:
          Name:
            NameFull: Ahmad, D.
      – PersonEntity:
          Name:
            NameFull: Samarawickrema, I.
      – PersonEntity:
          Name:
            NameFull: Sinclair, Justin (R19074)
      – PersonEntity:
          Name:
            NameFull: Kebriti, S.
      – PersonEntity:
          Name:
            NameFull: Maida, V.
      – PersonEntity:
          Name:
            NameFull: Thomas, J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
ResultId 1