Academic Journal
Προβολή σε EDS

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
Συγγραφείς: Lagou, V, Jiang, L, Ulrich, A, Zudina, L, González, KSG, Balkhiyarova, Z, Faggian, A, Maina, JG, Chen, S, Todorov, PV, Sharapov, S, David, A, Marullo, L, Mägi, R, Rujan, R-M, Ahlqvist, E, Thorleifsson, G, Gao, Η, Εvangelou, Ε, Benyamin, B, Scott, RA, Isaacs, A, Zhao, JH, Willems, SM, Johnson, T, Gieger, C, Grallert, H, Meisinger, C, Müller-Nurasyid, M, Strawbridge, RJ, Goel, A, Rybin, D, Albrecht, E, Jackson, AU, Stringham, HM, Corrêa, IR, Farber-Eger, E, Steinthorsdottir, V, Uitterlinden, AG, Munroe, PB, Brown, MJ, Schmidberger, J, Holmen, O, Thorand, B, Hveem, K, Wilsgaard, T, Mohlke, KL, Wang, Z, GWA-PA Consortium, Shmeliov, A, den Hoed, M, Loos, RJF, Kratzer, W, Haenle, M, Koenig, W, Boehm, BO, Tan, TM, Tomas, A, Salem, V, Barroso, I, Tuomilehto, J, Boehnke, M, Florez, JC, Hamsten, A, Watkins, H, Njølstad, I, Wichmann, H-E, Caulfield, MJ, Khaw, K-T, van Duijn, CM, Hofman, A, Wareham, NJ, Langenberg, C, Whitfield, JB, Martin, NG, Montgomery, G, Scapoli, C, Tzoulaki, I, Elliott, P, Thorsteinsdottir, U, Stefansson, K, Brittain, EL, McCarthy, MI, Froguel, P, Sexton, PM, Wootten, D, Groop, L, Dupuis, J, Meigs, JB, Deganutti, G, Demirkan, A, Pers, TH, Reynolds, CA, Aulchenko, YS, Kaakinen, MA, Jones, B, Prokopenko, I, Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC)
Έτος έκδοσης: 2023
Συλλογή: Queen Mary University of London: Queen Mary Research Online (QMRO)
Θεματικοί όροι: Humans, Glucose, Genome-Wide Association Study, Blood Glucose, Diabetes Mellitus, Type 2, Colon
Περιγραφή: Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations. We discovered 120 RG loci represented by 150 distinct signals, including 13 with sex-dimorphic effects, two cross-ancestry and seven rare frequency signals. Of these, 44 loci are new for glycemic traits. Regulatory, glycosylation and metagenomic annotations highlight ileum and colon tissues, indicating an underappreciated role of the gastrointestinal tract in controlling blood glucose. Functional follow-up and molecular dynamics simulations of lower frequency coding variants in glucagon-like peptide-1 receptor (GLP1R), a type 2 diabetes treatment target, reveal that optimal selection of GLP-1R agonist therapy will benefit from tailored genetic stratification. We also provide evidence from Mendelian randomization that lung function is modulated by blood glucose and that pulmonary dysfunction is a diabetes complication. Our investigation yields new insights into the biology of glucose regulation, diabetes complications and pathways for treatment stratification.
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: 1448 - 1461
Γλώσσα: English
Relation: Nat Genet; https://qmro.qmul.ac.uk/xmlui/handle/123456789/91149
DOI: 10.1038/s41588-023-01462-3
Διαθεσιμότητα: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91149
https://doi.org/10.1038/s41588-023-01462-3
Rights: Attribution 3.0 United States ; http://creativecommons.org/licenses/by/3.0/us/
Αριθμός Καταχώρησης: edsbas.1C059B2C
Βάση Δεδομένων: BASE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91149#
    Name: EDS - BASE (ns324271)
    Category: fullText
    Text: View record from BASE
Header DbId: edsbas
DbLabel: BASE
An: edsbas.1C059B2C
RelevancyScore: 926
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 926.330688476563
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lagou%2C+V%22">Lagou, V</searchLink><br /><searchLink fieldCode="AR" term="%22Jiang%2C+L%22">Jiang, L</searchLink><br /><searchLink fieldCode="AR" term="%22Ulrich%2C+A%22">Ulrich, A</searchLink><br /><searchLink fieldCode="AR" term="%22Zudina%2C+L%22">Zudina, L</searchLink><br /><searchLink fieldCode="AR" term="%22González%2C+KSG%22">González, KSG</searchLink><br /><searchLink fieldCode="AR" term="%22Balkhiyarova%2C+Z%22">Balkhiyarova, Z</searchLink><br /><searchLink fieldCode="AR" term="%22Faggian%2C+A%22">Faggian, A</searchLink><br /><searchLink fieldCode="AR" term="%22Maina%2C+JG%22">Maina, JG</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+S%22">Chen, S</searchLink><br /><searchLink fieldCode="AR" term="%22Todorov%2C+PV%22">Todorov, PV</searchLink><br /><searchLink fieldCode="AR" term="%22Sharapov%2C+S%22">Sharapov, S</searchLink><br /><searchLink fieldCode="AR" term="%22David%2C+A%22">David, A</searchLink><br /><searchLink fieldCode="AR" term="%22Marullo%2C+L%22">Marullo, L</searchLink><br /><searchLink fieldCode="AR" term="%22Mägi%2C+R%22">Mägi, R</searchLink><br /><searchLink fieldCode="AR" term="%22Rujan%2C+R-M%22">Rujan, R-M</searchLink><br /><searchLink fieldCode="AR" term="%22Ahlqvist%2C+E%22">Ahlqvist, E</searchLink><br /><searchLink fieldCode="AR" term="%22Thorleifsson%2C+G%22">Thorleifsson, G</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Η%22">Gao, Η</searchLink><br /><searchLink fieldCode="AR" term="%22Εvangelou%2C+Ε%22">Εvangelou, Ε</searchLink><br /><searchLink fieldCode="AR" term="%22Benyamin%2C+B%22">Benyamin, B</searchLink><br /><searchLink fieldCode="AR" term="%22Scott%2C+RA%22">Scott, RA</searchLink><br /><searchLink fieldCode="AR" term="%22Isaacs%2C+A%22">Isaacs, A</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+JH%22">Zhao, JH</searchLink><br /><searchLink fieldCode="AR" term="%22Willems%2C+SM%22">Willems, SM</searchLink><br /><searchLink fieldCode="AR" term="%22Johnson%2C+T%22">Johnson, T</searchLink><br /><searchLink fieldCode="AR" term="%22Gieger%2C+C%22">Gieger, C</searchLink><br /><searchLink fieldCode="AR" term="%22Grallert%2C+H%22">Grallert, H</searchLink><br /><searchLink fieldCode="AR" term="%22Meisinger%2C+C%22">Meisinger, C</searchLink><br /><searchLink fieldCode="AR" term="%22Müller-Nurasyid%2C+M%22">Müller-Nurasyid, M</searchLink><br /><searchLink fieldCode="AR" term="%22Strawbridge%2C+RJ%22">Strawbridge, RJ</searchLink><br /><searchLink fieldCode="AR" term="%22Goel%2C+A%22">Goel, A</searchLink><br /><searchLink fieldCode="AR" term="%22Rybin%2C+D%22">Rybin, D</searchLink><br /><searchLink fieldCode="AR" term="%22Albrecht%2C+E%22">Albrecht, E</searchLink><br /><searchLink fieldCode="AR" term="%22Jackson%2C+AU%22">Jackson, AU</searchLink><br /><searchLink fieldCode="AR" term="%22Stringham%2C+HM%22">Stringham, HM</searchLink><br /><searchLink fieldCode="AR" term="%22Corrêa%2C+IR%22">Corrêa, IR</searchLink><br /><searchLink fieldCode="AR" term="%22Farber-Eger%2C+E%22">Farber-Eger, E</searchLink><br /><searchLink fieldCode="AR" term="%22Steinthorsdottir%2C+V%22">Steinthorsdottir, V</searchLink><br /><searchLink fieldCode="AR" term="%22Uitterlinden%2C+AG%22">Uitterlinden, AG</searchLink><br /><searchLink fieldCode="AR" term="%22Munroe%2C+PB%22">Munroe, PB</searchLink><br /><searchLink fieldCode="AR" term="%22Brown%2C+MJ%22">Brown, MJ</searchLink><br /><searchLink fieldCode="AR" term="%22Schmidberger%2C+J%22">Schmidberger, J</searchLink><br /><searchLink fieldCode="AR" term="%22Holmen%2C+O%22">Holmen, O</searchLink><br /><searchLink fieldCode="AR" term="%22Thorand%2C+B%22">Thorand, B</searchLink><br /><searchLink fieldCode="AR" term="%22Hveem%2C+K%22">Hveem, K</searchLink><br /><searchLink fieldCode="AR" term="%22Wilsgaard%2C+T%22">Wilsgaard, T</searchLink><br /><searchLink fieldCode="AR" term="%22Mohlke%2C+KL%22">Mohlke, KL</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Z%22">Wang, Z</searchLink><br /><searchLink fieldCode="AR" term="%22GWA-PA+Consortium%22">GWA-PA Consortium</searchLink><br /><searchLink fieldCode="AR" term="%22Shmeliov%2C+A%22">Shmeliov, A</searchLink><br /><searchLink fieldCode="AR" term="%22den+Hoed%2C+M%22">den Hoed, M</searchLink><br /><searchLink fieldCode="AR" term="%22Loos%2C+RJF%22">Loos, RJF</searchLink><br /><searchLink fieldCode="AR" term="%22Kratzer%2C+W%22">Kratzer, W</searchLink><br /><searchLink fieldCode="AR" term="%22Haenle%2C+M%22">Haenle, M</searchLink><br /><searchLink fieldCode="AR" term="%22Koenig%2C+W%22">Koenig, W</searchLink><br /><searchLink fieldCode="AR" term="%22Boehm%2C+BO%22">Boehm, BO</searchLink><br /><searchLink fieldCode="AR" term="%22Tan%2C+TM%22">Tan, TM</searchLink><br /><searchLink fieldCode="AR" term="%22Tomas%2C+A%22">Tomas, A</searchLink><br /><searchLink fieldCode="AR" term="%22Salem%2C+V%22">Salem, V</searchLink><br /><searchLink fieldCode="AR" term="%22Barroso%2C+I%22">Barroso, I</searchLink><br /><searchLink fieldCode="AR" term="%22Tuomilehto%2C+J%22">Tuomilehto, J</searchLink><br /><searchLink fieldCode="AR" term="%22Boehnke%2C+M%22">Boehnke, M</searchLink><br /><searchLink fieldCode="AR" term="%22Florez%2C+JC%22">Florez, JC</searchLink><br /><searchLink fieldCode="AR" term="%22Hamsten%2C+A%22">Hamsten, A</searchLink><br /><searchLink fieldCode="AR" term="%22Watkins%2C+H%22">Watkins, H</searchLink><br /><searchLink fieldCode="AR" term="%22Njølstad%2C+I%22">Njølstad, I</searchLink><br /><searchLink fieldCode="AR" term="%22Wichmann%2C+H-E%22">Wichmann, H-E</searchLink><br /><searchLink fieldCode="AR" term="%22Caulfield%2C+MJ%22">Caulfield, MJ</searchLink><br /><searchLink fieldCode="AR" term="%22Khaw%2C+K-T%22">Khaw, K-T</searchLink><br /><searchLink fieldCode="AR" term="%22van+Duijn%2C+CM%22">van Duijn, CM</searchLink><br /><searchLink fieldCode="AR" term="%22Hofman%2C+A%22">Hofman, A</searchLink><br /><searchLink fieldCode="AR" term="%22Wareham%2C+NJ%22">Wareham, NJ</searchLink><br /><searchLink fieldCode="AR" term="%22Langenberg%2C+C%22">Langenberg, C</searchLink><br /><searchLink fieldCode="AR" term="%22Whitfield%2C+JB%22">Whitfield, JB</searchLink><br /><searchLink fieldCode="AR" term="%22Martin%2C+NG%22">Martin, NG</searchLink><br /><searchLink fieldCode="AR" term="%22Montgomery%2C+G%22">Montgomery, G</searchLink><br /><searchLink fieldCode="AR" term="%22Scapoli%2C+C%22">Scapoli, C</searchLink><br /><searchLink fieldCode="AR" term="%22Tzoulaki%2C+I%22">Tzoulaki, I</searchLink><br /><searchLink fieldCode="AR" term="%22Elliott%2C+P%22">Elliott, P</searchLink><br /><searchLink fieldCode="AR" term="%22Thorsteinsdottir%2C+U%22">Thorsteinsdottir, U</searchLink><br /><searchLink fieldCode="AR" term="%22Stefansson%2C+K%22">Stefansson, K</searchLink><br /><searchLink fieldCode="AR" term="%22Brittain%2C+EL%22">Brittain, EL</searchLink><br /><searchLink fieldCode="AR" term="%22McCarthy%2C+MI%22">McCarthy, MI</searchLink><br /><searchLink fieldCode="AR" term="%22Froguel%2C+P%22">Froguel, P</searchLink><br /><searchLink fieldCode="AR" term="%22Sexton%2C+PM%22">Sexton, PM</searchLink><br /><searchLink fieldCode="AR" term="%22Wootten%2C+D%22">Wootten, D</searchLink><br /><searchLink fieldCode="AR" term="%22Groop%2C+L%22">Groop, L</searchLink><br /><searchLink fieldCode="AR" term="%22Dupuis%2C+J%22">Dupuis, J</searchLink><br /><searchLink fieldCode="AR" term="%22Meigs%2C+JB%22">Meigs, JB</searchLink><br /><searchLink fieldCode="AR" term="%22Deganutti%2C+G%22">Deganutti, G</searchLink><br /><searchLink fieldCode="AR" term="%22Demirkan%2C+A%22">Demirkan, A</searchLink><br /><searchLink fieldCode="AR" term="%22Pers%2C+TH%22">Pers, TH</searchLink><br /><searchLink fieldCode="AR" term="%22Reynolds%2C+CA%22">Reynolds, CA</searchLink><br /><searchLink fieldCode="AR" term="%22Aulchenko%2C+YS%22">Aulchenko, YS</searchLink><br /><searchLink fieldCode="AR" term="%22Kaakinen%2C+MA%22">Kaakinen, MA</searchLink><br /><searchLink fieldCode="AR" term="%22Jones%2C+B%22">Jones, B</searchLink><br /><searchLink fieldCode="AR" term="%22Prokopenko%2C+I%22">Prokopenko, I</searchLink><br /><searchLink fieldCode="AR" term="%22Meta-Analysis+of+Glucose+and+Insulin-Related+Traits+Consortium+%28MAGIC%29%22">Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC)</searchLink>
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2023
– Name: Subset
  Label: Collection
  Group: HoldingsInfo
  Data: Queen Mary University of London: Queen Mary Research Online (QMRO)
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose%22">Glucose</searchLink><br /><searchLink fieldCode="DE" term="%22Genome-Wide+Association+Study%22">Genome-Wide Association Study</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+Glucose%22">Blood Glucose</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+Mellitus%22">Diabetes Mellitus</searchLink><br /><searchLink fieldCode="DE" term="%22Type+2%22">Type 2</searchLink><br /><searchLink fieldCode="DE" term="%22Colon%22">Colon</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations. We discovered 120 RG loci represented by 150 distinct signals, including 13 with sex-dimorphic effects, two cross-ancestry and seven rare frequency signals. Of these, 44 loci are new for glycemic traits. Regulatory, glycosylation and metagenomic annotations highlight ileum and colon tissues, indicating an underappreciated role of the gastrointestinal tract in controlling blood glucose. Functional follow-up and molecular dynamics simulations of lower frequency coding variants in glucagon-like peptide-1 receptor (GLP1R), a type 2 diabetes treatment target, reveal that optimal selection of GLP-1R agonist therapy will benefit from tailored genetic stratification. We also provide evidence from Mendelian randomization that lung function is modulated by blood glucose and that pulmonary dysfunction is a diabetes complication. Our investigation yields new insights into the biology of glucose regulation, diabetes complications and pathways for treatment stratification.
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: article in journal/newspaper
– Name: Format
  Label: File Description
  Group: SrcInfo
  Data: 1448 - 1461
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: NoteTitleSource
  Label: Relation
  Group: SrcInfo
  Data: Nat Genet; https://qmro.qmul.ac.uk/xmlui/handle/123456789/91149
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1038/s41588-023-01462-3
– Name: URL
  Label: Availability
  Group: URL
  Data: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91149<br />https://doi.org/10.1038/s41588-023-01462-3
– Name: Copyright
  Label: Rights
  Group: Cpyrght
  Data: Attribution 3.0 United States ; http://creativecommons.org/licenses/by/3.0/us/
– Name: AN
  Label: Accession Number
  Group: ID
  Data: edsbas.1C059B2C
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.1C059B2C
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41588-023-01462-3
    Languages:
      – Text: English
    Subjects:
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Glucose
        Type: general
      – SubjectFull: Genome-Wide Association Study
        Type: general
      – SubjectFull: Blood Glucose
        Type: general
      – SubjectFull: Diabetes Mellitus
        Type: general
      – SubjectFull: Type 2
        Type: general
      – SubjectFull: Colon
        Type: general
    Titles:
      – TitleFull: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lagou, V
      – PersonEntity:
          Name:
            NameFull: Jiang, L
      – PersonEntity:
          Name:
            NameFull: Ulrich, A
      – PersonEntity:
          Name:
            NameFull: Zudina, L
      – PersonEntity:
          Name:
            NameFull: González, KSG
      – PersonEntity:
          Name:
            NameFull: Balkhiyarova, Z
      – PersonEntity:
          Name:
            NameFull: Faggian, A
      – PersonEntity:
          Name:
            NameFull: Maina, JG
      – PersonEntity:
          Name:
            NameFull: Chen, S
      – PersonEntity:
          Name:
            NameFull: Todorov, PV
      – PersonEntity:
          Name:
            NameFull: Sharapov, S
      – PersonEntity:
          Name:
            NameFull: David, A
      – PersonEntity:
          Name:
            NameFull: Marullo, L
      – PersonEntity:
          Name:
            NameFull: Mägi, R
      – PersonEntity:
          Name:
            NameFull: Rujan, R-M
      – PersonEntity:
          Name:
            NameFull: Ahlqvist, E
      – PersonEntity:
          Name:
            NameFull: Thorleifsson, G
      – PersonEntity:
          Name:
            NameFull: Gao, Η
      – PersonEntity:
          Name:
            NameFull: Εvangelou, Ε
      – PersonEntity:
          Name:
            NameFull: Benyamin, B
      – PersonEntity:
          Name:
            NameFull: Scott, RA
      – PersonEntity:
          Name:
            NameFull: Isaacs, A
      – PersonEntity:
          Name:
            NameFull: Zhao, JH
      – PersonEntity:
          Name:
            NameFull: Willems, SM
      – PersonEntity:
          Name:
            NameFull: Johnson, T
      – PersonEntity:
          Name:
            NameFull: Gieger, C
      – PersonEntity:
          Name:
            NameFull: Grallert, H
      – PersonEntity:
          Name:
            NameFull: Meisinger, C
      – PersonEntity:
          Name:
            NameFull: Müller-Nurasyid, M
      – PersonEntity:
          Name:
            NameFull: Strawbridge, RJ
      – PersonEntity:
          Name:
            NameFull: Goel, A
      – PersonEntity:
          Name:
            NameFull: Rybin, D
      – PersonEntity:
          Name:
            NameFull: Albrecht, E
      – PersonEntity:
          Name:
            NameFull: Jackson, AU
      – PersonEntity:
          Name:
            NameFull: Stringham, HM
      – PersonEntity:
          Name:
            NameFull: Corrêa, IR
      – PersonEntity:
          Name:
            NameFull: Farber-Eger, E
      – PersonEntity:
          Name:
            NameFull: Steinthorsdottir, V
      – PersonEntity:
          Name:
            NameFull: Uitterlinden, AG
      – PersonEntity:
          Name:
            NameFull: Munroe, PB
      – PersonEntity:
          Name:
            NameFull: Brown, MJ
      – PersonEntity:
          Name:
            NameFull: Schmidberger, J
      – PersonEntity:
          Name:
            NameFull: Holmen, O
      – PersonEntity:
          Name:
            NameFull: Thorand, B
      – PersonEntity:
          Name:
            NameFull: Hveem, K
      – PersonEntity:
          Name:
            NameFull: Wilsgaard, T
      – PersonEntity:
          Name:
            NameFull: Mohlke, KL
      – PersonEntity:
          Name:
            NameFull: Wang, Z
      – PersonEntity:
          Name:
            NameFull: GWA-PA Consortium
      – PersonEntity:
          Name:
            NameFull: Shmeliov, A
      – PersonEntity:
          Name:
            NameFull: den Hoed, M
      – PersonEntity:
          Name:
            NameFull: Loos, RJF
      – PersonEntity:
          Name:
            NameFull: Kratzer, W
      – PersonEntity:
          Name:
            NameFull: Haenle, M
      – PersonEntity:
          Name:
            NameFull: Koenig, W
      – PersonEntity:
          Name:
            NameFull: Boehm, BO
      – PersonEntity:
          Name:
            NameFull: Tan, TM
      – PersonEntity:
          Name:
            NameFull: Tomas, A
      – PersonEntity:
          Name:
            NameFull: Salem, V
      – PersonEntity:
          Name:
            NameFull: Barroso, I
      – PersonEntity:
          Name:
            NameFull: Tuomilehto, J
      – PersonEntity:
          Name:
            NameFull: Boehnke, M
      – PersonEntity:
          Name:
            NameFull: Florez, JC
      – PersonEntity:
          Name:
            NameFull: Hamsten, A
      – PersonEntity:
          Name:
            NameFull: Watkins, H
      – PersonEntity:
          Name:
            NameFull: Njølstad, I
      – PersonEntity:
          Name:
            NameFull: Wichmann, H-E
      – PersonEntity:
          Name:
            NameFull: Caulfield, MJ
      – PersonEntity:
          Name:
            NameFull: Khaw, K-T
      – PersonEntity:
          Name:
            NameFull: van Duijn, CM
      – PersonEntity:
          Name:
            NameFull: Hofman, A
      – PersonEntity:
          Name:
            NameFull: Wareham, NJ
      – PersonEntity:
          Name:
            NameFull: Langenberg, C
      – PersonEntity:
          Name:
            NameFull: Whitfield, JB
      – PersonEntity:
          Name:
            NameFull: Martin, NG
      – PersonEntity:
          Name:
            NameFull: Montgomery, G
      – PersonEntity:
          Name:
            NameFull: Scapoli, C
      – PersonEntity:
          Name:
            NameFull: Tzoulaki, I
      – PersonEntity:
          Name:
            NameFull: Elliott, P
      – PersonEntity:
          Name:
            NameFull: Thorsteinsdottir, U
      – PersonEntity:
          Name:
            NameFull: Stefansson, K
      – PersonEntity:
          Name:
            NameFull: Brittain, EL
      – PersonEntity:
          Name:
            NameFull: McCarthy, MI
      – PersonEntity:
          Name:
            NameFull: Froguel, P
      – PersonEntity:
          Name:
            NameFull: Sexton, PM
      – PersonEntity:
          Name:
            NameFull: Wootten, D
      – PersonEntity:
          Name:
            NameFull: Groop, L
      – PersonEntity:
          Name:
            NameFull: Dupuis, J
      – PersonEntity:
          Name:
            NameFull: Meigs, JB
      – PersonEntity:
          Name:
            NameFull: Deganutti, G
      – PersonEntity:
          Name:
            NameFull: Demirkan, A
      – PersonEntity:
          Name:
            NameFull: Pers, TH
      – PersonEntity:
          Name:
            NameFull: Reynolds, CA
      – PersonEntity:
          Name:
            NameFull: Aulchenko, YS
      – PersonEntity:
          Name:
            NameFull: Kaakinen, MA
      – PersonEntity:
          Name:
            NameFull: Jones, B
      – PersonEntity:
          Name:
            NameFull: Prokopenko, I
      – PersonEntity:
          Name:
            NameFull: Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC)
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-locals
              Value: edsbas
            – Type: issn-locals
              Value: edsbas.oa
ResultId 1