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Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy

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Title: Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy
Authors: Winnand, Philipp, Ooms, Mark, Heitzer, Marius, Vohl, Nils, Lammert, Matthias, Hölzle, Frank, Boernsen, K. Olaf, Modabber, Ali
Source: http://lobid.org/resources/99370672697806441#!, 28(9):474.
Publication Year: 2024
Collection: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Subject Terms: Female [MeSH], Laser-induced breakdown spectroscopy, Mouth Neoplasms/pathology [MeSH], Spectrum Analysis/methods [MeSH], Aged [MeSH], Rapid bone analysis, Humans [MeSH], Margins of Excision [MeSH], Middle Aged [MeSH], Neoplasm Invasiveness [MeSH], Bone-invasive oral cancer, Lasers [MeSH], Mouth Neoplasms/surgery [MeSH], Male [MeSH], Potassium/analysis [MeSH], Research, Mandible/surgery [MeSH], Calcium/analysis [MeSH], Bone tumor resection margins, Mandible/pathology [MeSH]
Description: Abstract Objectives Inadequate resection margins of less than 5 mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS). Materials and methods LIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins < 1 mm were defined as very close, from 1–5 mm as close, and > 5 mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined. Results LIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis/fibrosis and lymphocyte/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (p < 0.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%. Conclusions LIBS can reliably determine the boundary of bone-infiltrating tumors and might ...
Document Type: article in journal/newspaper
Language: English
Relation: https://repository.publisso.de/resource/frl:6521299; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306308/
DOI: 10.1007/s00784-024-05862-5
Availability: https://repository.publisso.de/resource/frl:6521299
https://doi.org/10.1007/s00784-024-05862-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306308/
Rights: https://creativecommons.org/licenses/by/4.0/
Accession Number: edsbas.197BD5C2
Database: BASE
Description
DOI:10.1007/s00784-024-05862-5