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Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy

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Title: Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy
Authors: Winnand, Philipp, Ooms, Mark, Heitzer, Marius, Vohl, Nils, Lammert, Matthias, Hölzle, Frank, Boernsen, K. Olaf, Modabber, Ali
Source: http://lobid.org/resources/99370672697806441#!, 28(9):474.
Publication Year: 2024
Collection: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
Subject Terms: Female [MeSH], Laser-induced breakdown spectroscopy, Mouth Neoplasms/pathology [MeSH], Spectrum Analysis/methods [MeSH], Aged [MeSH], Rapid bone analysis, Humans [MeSH], Margins of Excision [MeSH], Middle Aged [MeSH], Neoplasm Invasiveness [MeSH], Bone-invasive oral cancer, Lasers [MeSH], Mouth Neoplasms/surgery [MeSH], Male [MeSH], Potassium/analysis [MeSH], Research, Mandible/surgery [MeSH], Calcium/analysis [MeSH], Bone tumor resection margins, Mandible/pathology [MeSH]
Description: Abstract Objectives Inadequate resection margins of less than 5 mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS). Materials and methods LIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins < 1 mm were defined as very close, from 1–5 mm as close, and > 5 mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined. Results LIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis/fibrosis and lymphocyte/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (p < 0.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%. Conclusions LIBS can reliably determine the boundary of bone-infiltrating tumors and might ...
Document Type: article in journal/newspaper
Language: English
Relation: https://repository.publisso.de/resource/frl:6521299; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306308/
DOI: 10.1007/s00784-024-05862-5
Availability: https://repository.publisso.de/resource/frl:6521299
https://doi.org/10.1007/s00784-024-05862-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306308/
Rights: https://creativecommons.org/licenses/by/4.0/
Accession Number: edsbas.197BD5C2
Database: BASE
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  Data: Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Winnand%2C+Philipp%22&quot;&gt;Winnand, Philipp&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ooms%2C+Mark%22&quot;&gt;Ooms, Mark&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Heitzer%2C+Marius%22&quot;&gt;Heitzer, Marius&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vohl%2C+Nils%22&quot;&gt;Vohl, Nils&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lammert%2C+Matthias%22&quot;&gt;Lammert, Matthias&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22H&#246;lzle%2C+Frank%22&quot;&gt;H&#246;lzle, Frank&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Boernsen%2C+K%2E+Olaf%22&quot;&gt;Boernsen, K. Olaf&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Modabber%2C+Ali%22&quot;&gt;Modabber, Ali&lt;/searchLink&gt;
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  Data: 2024
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  Data: Publisso (ZB MED-Publikationsportal Lebenswissenschaften)
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Female+[MeSH]%22&quot;&gt;Female [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Laser-induced+breakdown+spectroscopy%22&quot;&gt;Laser-induced breakdown spectroscopy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mouth+Neoplasms%2Fpathology+[MeSH]%22&quot;&gt;Mouth Neoplasms/pathology [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Spectrum+Analysis%2Fmethods+[MeSH]%22&quot;&gt;Spectrum Analysis/methods [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Aged+[MeSH]%22&quot;&gt;Aged [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Rapid+bone+analysis%22&quot;&gt;Rapid bone analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Humans+[MeSH]%22&quot;&gt;Humans [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Margins+of+Excision+[MeSH]%22&quot;&gt;Margins of Excision [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Middle+Aged+[MeSH]%22&quot;&gt;Middle Aged [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neoplasm+Invasiveness+[MeSH]%22&quot;&gt;Neoplasm Invasiveness [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bone-invasive+oral+cancer%22&quot;&gt;Bone-invasive oral cancer&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Lasers+[MeSH]%22&quot;&gt;Lasers [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mouth+Neoplasms%2Fsurgery+[MeSH]%22&quot;&gt;Mouth Neoplasms/surgery [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Male+[MeSH]%22&quot;&gt;Male [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Potassium%2Fanalysis+[MeSH]%22&quot;&gt;Potassium/analysis [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research%22&quot;&gt;Research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mandible%2Fsurgery+[MeSH]%22&quot;&gt;Mandible/surgery [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Calcium%2Fanalysis+[MeSH]%22&quot;&gt;Calcium/analysis [MeSH]&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bone+tumor+resection+margins%22&quot;&gt;Bone tumor resection margins&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mandible%2Fpathology+[MeSH]%22&quot;&gt;Mandible/pathology [MeSH]&lt;/searchLink&gt;
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  Data: &lt;jats:title&gt;Abstract&lt;/jats:title&gt;&lt;jats:sec&gt; &lt;jats:title&gt;Objectives&lt;/jats:title&gt; &lt;jats:p&gt;Inadequate resection margins of less than 5 mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS).&lt;/jats:p&gt; &lt;/jats:sec&gt;&lt;jats:sec&gt; &lt;jats:title&gt;Materials and methods&lt;/jats:title&gt; &lt;jats:p&gt;LIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins &lt; 1 mm were defined as very close, from 1–5 mm as close, and &gt; 5 mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined.&lt;/jats:p&gt; &lt;/jats:sec&gt;&lt;jats:sec&gt; &lt;jats:title&gt;Results&lt;/jats:title&gt; &lt;jats:p&gt;LIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis/fibrosis and lymphocyte/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (&lt;jats:italic&gt;p&lt;/jats:italic&gt; &lt; 0.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%.&lt;/jats:p&gt; &lt;/jats:sec&gt;&lt;jats:sec&gt; &lt;jats:title&gt;Conclusions&lt;/jats:title&gt; &lt;jats:p&gt;LIBS can reliably determine the boundary of bone-infiltrating tumors and might ...
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  Data: 10.1007/s00784-024-05862-5
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        Value: 10.1007/s00784-024-05862-5
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      – Text: English
    Subjects:
      – SubjectFull: Female [MeSH]
        Type: general
      – SubjectFull: Laser-induced breakdown spectroscopy
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      – SubjectFull: Mouth Neoplasms/pathology [MeSH]
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      – SubjectFull: Aged [MeSH]
        Type: general
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      – SubjectFull: Humans [MeSH]
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      – SubjectFull: Margins of Excision [MeSH]
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      – SubjectFull: Middle Aged [MeSH]
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      – SubjectFull: Neoplasm Invasiveness [MeSH]
        Type: general
      – SubjectFull: Bone-invasive oral cancer
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      – SubjectFull: Male [MeSH]
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      – SubjectFull: Calcium/analysis [MeSH]
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      – TitleFull: Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy
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              Type: published
              Y: 2024
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