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Analysis of well-annotated next-generation sequencing data reveals increasing cases of SARS-CoV-2 reinfection with Omicron

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Analysis of well-annotated next-generation sequencing data reveals increasing cases of SARS-CoV-2 reinfection with Omicron
Συγγραφείς: Burkholz, Scott, Rubsamen, Michael, Blankenberg, Luke, Carback, III, Richard T., Mochly-Rosen, Daria, Harris, Paul Emerson
Έτος έκδοσης: 2023
Συλλογή: Columbia University: Academic Commons
Θεματικοί όροι: Virus diseases, COVID-19 (Disease)--Data processing, Genetics--Data processing, High-throughput nucleotide sequencing
Περιγραφή: SARS-CoV-2 has extensively mutated creating variants of concern (VOC) resulting in global infection surges. The Omicron VOC reinfects individuals exposed to earlier variants of SARS-CoV-2 at a higher frequency than previously seen for non-Omicron VOC. An analysis of the sub-lineages associated with an Omicron primary infection and Omicron reinfection reveals that the incidence of Omicron-Omicron reinfections is occurring over a shorter time interval than seen after a primary infection with a non-Omicron VOC. Our analysis suggests that a single infection from SARS-CoV-2 may not generate the protective immunity required to defend against reinfections from emerging Omicron lineages. This analysis was made possible by Next-generation sequencing (NGS) of a Danish cohort with clinical metadata on both infections occurring in the same individual. We suggest that the continuation of COVID-19 NGS and inclusion of clinical metadata is necessary to ensure effective surveillance of SARS-CoV-2 genomics, assist in treatment and vaccine development, and guide public health recommendations.
Τύπος εγγράφου: article in journal/newspaper
Γλώσσα: English
DOI: 10.7916/c86y-0g98
Διαθεσιμότητα: https://doi.org/10.7916/c86y-0g98
Αριθμός Καταχώρησης: edsbas.16DCD1A9
Βάση Δεδομένων: BASE
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  – Url: https://doi.org/10.7916/c86y-0g98#
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  Data: Analysis of well-annotated next-generation sequencing data reveals increasing cases of SARS-CoV-2 reinfection with Omicron
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  Data: <searchLink fieldCode="AR" term="%22Burkholz%2C+Scott%22">Burkholz, Scott</searchLink><br /><searchLink fieldCode="AR" term="%22Rubsamen%2C+Michael%22">Rubsamen, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Blankenberg%2C+Luke%22">Blankenberg, Luke</searchLink><br /><searchLink fieldCode="AR" term="%22Carback%2C+III%2C+Richard+T%2E%22">Carback, III, Richard T.</searchLink><br /><searchLink fieldCode="AR" term="%22Mochly-Rosen%2C+Daria%22">Mochly-Rosen, Daria</searchLink><br /><searchLink fieldCode="AR" term="%22Harris%2C+Paul+Emerson%22">Harris, Paul Emerson</searchLink>
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  Data: 2023
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  Data: Columbia University: Academic Commons
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  Data: <searchLink fieldCode="DE" term="%22Virus+diseases%22">Virus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+%28Disease%29--Data+processing%22">COVID-19 (Disease)--Data processing</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics--Data+processing%22">Genetics--Data processing</searchLink><br /><searchLink fieldCode="DE" term="%22High-throughput+nucleotide+sequencing%22">High-throughput nucleotide sequencing</searchLink>
– Name: Abstract
  Label: Description
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  Data: SARS-CoV-2 has extensively mutated creating variants of concern (VOC) resulting in global infection surges. The Omicron VOC reinfects individuals exposed to earlier variants of SARS-CoV-2 at a higher frequency than previously seen for non-Omicron VOC. An analysis of the sub-lineages associated with an Omicron primary infection and Omicron reinfection reveals that the incidence of Omicron-Omicron reinfections is occurring over a shorter time interval than seen after a primary infection with a non-Omicron VOC. Our analysis suggests that a single infection from SARS-CoV-2 may not generate the protective immunity required to defend against reinfections from emerging Omicron lineages. This analysis was made possible by Next-generation sequencing (NGS) of a Danish cohort with clinical metadata on both infections occurring in the same individual. We suggest that the continuation of COVID-19 NGS and inclusion of clinical metadata is necessary to ensure effective surveillance of SARS-CoV-2 genomics, assist in treatment and vaccine development, and guide public health recommendations.
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  Data: 10.7916/c86y-0g98
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