Academic Journal
Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment
| Τίτλος: | Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment |
|---|---|
| Συγγραφείς: | Javitt, Daniel C., Martinez, Antigona, Sehatpour, Pejman, Beloborodova, Anna, Habeck, Christian, Gazes, Yunglin, Bermudez, Dalton, Razlighi, Qolamreza R., Devanand, D. P., Stern, Yaakov |
| Έτος έκδοσης: | 2023 |
| Συλλογή: | Columbia University: Academic Commons |
| Θεματικοί όροι: | Amyloid beta-protein, Cognition--Social aspects, Alzheimer's disease--Pathogenesis, Visual perception--Data processing, Older people--Health risk assessment |
| Περιγραφή: | Background Amyloid deposition is a primary predictor of Alzheimer’s disease (AD) and related neurodegenerative disorders. Retinal changes involving the structure and function of the ganglion cell layer are increasingly documented in both established and prodromal AD. Visual event-related potentials (vERP) are sensitive to dysfunction in the magno- and parvocellular visual systems, which originate within the retinal ganglion cell layer. The present study evaluates vERP as a function of amyloid deposition in aging, and in mild cognitive impairment (MCI). Methods vERP to stimulus-onset, motion-onset, and alpha-frequency steady-state (ssVEP) stimuli were obtained from 16 amyloid-positive and 41 amyloid-negative healthy elders and 15 MCI individuals and analyzed using time–frequency approaches. Social cognition was assessed in a subset of individuals using The Awareness of Social Inference Test (TASIT). Results Neurocognitively intact but amyloid-positive participants and MCI individuals showed significant deficits in stimulus-onset (theta) and motion-onset (delta) vERP generation relative to amyloid-negative participants (all p < .01). Across healthy elders, a composite index of these measures correlated highly (r = − .52, p < .001) with amyloid standardized uptake value ratios (SUVR) and TASIT performance. A composite index composed of vERP measures significant differentiated amyloid-positive and amyloid-negative groups with an overall classification accuracy of > 70%. Discussion vERP may assist in the early detection of amyloid deposition among older individuals without observable neurocognitive impairments and in linking previously documented retinal deficits in both prodromal AD and MCI to behavioral impairments in social cognition. |
| Τύπος εγγράφου: | article in journal/newspaper |
| Γλώσσα: | English |
| DOI: | 10.7916/7w1z-sf80 |
| Διαθεσιμότητα: | https://doi.org/10.7916/7w1z-sf80 |
| Αριθμός Καταχώρησης: | edsbas.154F7925 |
| Βάση Δεδομένων: | BASE |
| FullText | Text: Availability: 0 CustomLinks: – Url: https://doi.org/10.7916/7w1z-sf80# Name: EDS - BASE (ns324271) Category: fullText Text: View record from BASE |
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| Header | DbId: edsbas DbLabel: BASE An: edsbas.154F7925 RelevancyScore: 929 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 929.480346679688 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Javitt%2C+Daniel+C%2E%22">Javitt, Daniel C.</searchLink><br /><searchLink fieldCode="AR" term="%22Martinez%2C+Antigona%22">Martinez, Antigona</searchLink><br /><searchLink fieldCode="AR" term="%22Sehatpour%2C+Pejman%22">Sehatpour, Pejman</searchLink><br /><searchLink fieldCode="AR" term="%22Beloborodova%2C+Anna%22">Beloborodova, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Habeck%2C+Christian%22">Habeck, Christian</searchLink><br /><searchLink fieldCode="AR" term="%22Gazes%2C+Yunglin%22">Gazes, Yunglin</searchLink><br /><searchLink fieldCode="AR" term="%22Bermudez%2C+Dalton%22">Bermudez, Dalton</searchLink><br /><searchLink fieldCode="AR" term="%22Razlighi%2C+Qolamreza+R%2E%22">Razlighi, Qolamreza R.</searchLink><br /><searchLink fieldCode="AR" term="%22Devanand%2C+D%2E+P%2E%22">Devanand, D. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Stern%2C+Yaakov%22">Stern, Yaakov</searchLink> – Name: DatePubCY Label: Publication Year Group: Date Data: 2023 – Name: Subset Label: Collection Group: HoldingsInfo Data: Columbia University: Academic Commons – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Amyloid+beta-protein%22">Amyloid beta-protein</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition--Social+aspects%22">Cognition--Social aspects</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease--Pathogenesis%22">Alzheimer's disease--Pathogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+perception--Data+processing%22">Visual perception--Data processing</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people--Health+risk+assessment%22">Older people--Health risk assessment</searchLink> – Name: Abstract Label: Description Group: Ab Data: Background Amyloid deposition is a primary predictor of Alzheimer’s disease (AD) and related neurodegenerative disorders. Retinal changes involving the structure and function of the ganglion cell layer are increasingly documented in both established and prodromal AD. Visual event-related potentials (vERP) are sensitive to dysfunction in the magno- and parvocellular visual systems, which originate within the retinal ganglion cell layer. The present study evaluates vERP as a function of amyloid deposition in aging, and in mild cognitive impairment (MCI). Methods vERP to stimulus-onset, motion-onset, and alpha-frequency steady-state (ssVEP) stimuli were obtained from 16 amyloid-positive and 41 amyloid-negative healthy elders and 15 MCI individuals and analyzed using time–frequency approaches. Social cognition was assessed in a subset of individuals using The Awareness of Social Inference Test (TASIT). Results Neurocognitively intact but amyloid-positive participants and MCI individuals showed significant deficits in stimulus-onset (theta) and motion-onset (delta) vERP generation relative to amyloid-negative participants (all p < .01). Across healthy elders, a composite index of these measures correlated highly (r = − .52, p < .001) with amyloid standardized uptake value ratios (SUVR) and TASIT performance. A composite index composed of vERP measures significant differentiated amyloid-positive and amyloid-negative groups with an overall classification accuracy of > 70%. Discussion vERP may assist in the early detection of amyloid deposition among older individuals without observable neurocognitive impairments and in linking previously documented retinal deficits in both prodromal AD and MCI to behavioral impairments in social cognition. – Name: TypeDocument Label: Document Type Group: TypDoc Data: article in journal/newspaper – Name: Language Label: Language Group: Lang Data: English – Name: DOI Label: DOI Group: ID Data: 10.7916/7w1z-sf80 – Name: URL Label: Availability Group: URL Data: https://doi.org/10.7916/7w1z-sf80 – Name: AN Label: Accession Number Group: ID Data: edsbas.154F7925 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsbas&AN=edsbas.154F7925 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7916/7w1z-sf80 Languages: – Text: English Subjects: – SubjectFull: Amyloid beta-protein Type: general – SubjectFull: Cognition--Social aspects Type: general – SubjectFull: Alzheimer's disease--Pathogenesis Type: general – SubjectFull: Visual perception--Data processing Type: general – SubjectFull: Older people--Health risk assessment Type: general Titles: – TitleFull: Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Javitt, Daniel C. – PersonEntity: Name: NameFull: Martinez, Antigona – PersonEntity: Name: NameFull: Sehatpour, Pejman – PersonEntity: Name: NameFull: Beloborodova, Anna – PersonEntity: Name: NameFull: Habeck, Christian – PersonEntity: Name: NameFull: Gazes, Yunglin – PersonEntity: Name: NameFull: Bermudez, Dalton – PersonEntity: Name: NameFull: Razlighi, Qolamreza R. – PersonEntity: Name: NameFull: Devanand, D. P. – PersonEntity: Name: NameFull: Stern, Yaakov IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Type: published Y: 2023 Identifiers: – Type: issn-locals Value: edsbas – Type: issn-locals Value: edsbas.oa |
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