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Costs-effectiveness and cost components of pharmaceutical and non-pharmaceutical interventions affecting antibiotic resistance outcomes in hospital patients: a systematic literature review

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Τίτλος: Costs-effectiveness and cost components of pharmaceutical and non-pharmaceutical interventions affecting antibiotic resistance outcomes in hospital patients: a systematic literature review
Συγγραφείς: Allel, K. (Kasim), Hernández-Leal, M.J. (María José), Naylor, N.R. (Nichola R.), Undurraga, E.A. (Eduardo A.), Abou-Jaoude, G.J. (Gerard Joseph), Bhandari, P. (Priyanka), Flanagan, E. (Ellen), Haghparast-Bidgoli, H. (Hassan), Pouwels, K.B. (Koen B.), Yakob, L. (Laith)
Έτος έκδοσης: 2024
Συλλογή: dadun - Depósito Académico Digital Universidad de Navarra
Θεματικοί όροι: Área Economía
Περιγραφή: Introduction: Limited information on costs and the cost-effectiveness of hospital interventions to reduce antibiotic resistance (ABR) hinder efficient resource allocation. Methods: We conducted a systematic literature review for studies evaluating the costs and cost-effectiveness of pharmaceutical and non-pharmaceutical interventions aimed at reducing, monitoring and controlling ABR in patients. Articles published until 12 December 2023 were explored using EconLit, EMBASE and PubMed. We focused on critical or high-priority bacteria, as defined by the WHO, and intervention costs and incremental cost-effectiveness ratio (ICER). Following Preferred Reporting Items for Systematic review and Meta-Analysis guidelines, we extracted unit costs, ICERs and essential study information including country, intervention, bacteria-drug combination, discount rates, type of model and outcomes. Costs were reported in 2022 US dollars ($), adopting the healthcare system perspective. Country willingness-to-pay (WTP) thresholds from Woods et al 2016 guided cost-effectiveness assessments. We assessed the studies reporting checklist using Drummond¿s method. Results: Among 20.958 articles, 59 (32 pharmaceutical and 27 non-pharmaceutical interventions) met the inclusion criteria. Non-pharmaceutical interventions, such as hygiene measures, had unit costs as low as $1 per patient, contrasting with generally higher pharmaceutical intervention costs. Several studies found that linezolid-based treatments for methicillin-resistant Staphylococcus aureus were cost-effective compared with vancomycin (ICER up to $21¿488 per treatment success, all 16 studies¿ ICERs
Τύπος εγγράφου: review
Περιγραφή αρχείου: application/pdf
Γλώσσα: English
Relation: https://gh.bmj.com/content/9/2/e013205.abstract; https://hdl.handle.net/10171/69982
Διαθεσιμότητα: https://hdl.handle.net/10171/69982
Rights: info:eu-repo/semantics/openAccess
Αριθμός Καταχώρησης: edsbas.14CB7CE
Βάση Δεδομένων: BASE
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  – Url: https://hdl.handle.net/10171/69982#
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  Data: Costs-effectiveness and cost components of pharmaceutical and non-pharmaceutical interventions affecting antibiotic resistance outcomes in hospital patients: a systematic literature review
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  Data: <searchLink fieldCode="AR" term="%22Allel%2C+K%2E+%28Kasim%29%22">Allel, K. (Kasim)</searchLink><br /><searchLink fieldCode="AR" term="%22Hernández-Leal%2C+M%2EJ%2E+%28María+José%29%22">Hernández-Leal, M.J. (María José)</searchLink><br /><searchLink fieldCode="AR" term="%22Naylor%2C+N%2ER%2E+%28Nichola+R%2E%29%22">Naylor, N.R. (Nichola R.)</searchLink><br /><searchLink fieldCode="AR" term="%22Undurraga%2C+E%2EA%2E+%28Eduardo+A%2E%29%22">Undurraga, E.A. (Eduardo A.)</searchLink><br /><searchLink fieldCode="AR" term="%22Abou-Jaoude%2C+G%2EJ%2E+%28Gerard+Joseph%29%22">Abou-Jaoude, G.J. (Gerard Joseph)</searchLink><br /><searchLink fieldCode="AR" term="%22Bhandari%2C+P%2E+%28Priyanka%29%22">Bhandari, P. (Priyanka)</searchLink><br /><searchLink fieldCode="AR" term="%22Flanagan%2C+E%2E+%28Ellen%29%22">Flanagan, E. (Ellen)</searchLink><br /><searchLink fieldCode="AR" term="%22Haghparast-Bidgoli%2C+H%2E+%28Hassan%29%22">Haghparast-Bidgoli, H. (Hassan)</searchLink><br /><searchLink fieldCode="AR" term="%22Pouwels%2C+K%2EB%2E+%28Koen+B%2E%29%22">Pouwels, K.B. (Koen B.)</searchLink><br /><searchLink fieldCode="AR" term="%22Yakob%2C+L%2E+%28Laith%29%22">Yakob, L. (Laith)</searchLink>
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  Data: 2024
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  Data: Introduction: Limited information on costs and the cost-effectiveness of hospital interventions to reduce antibiotic resistance (ABR) hinder efficient resource allocation. Methods: We conducted a systematic literature review for studies evaluating the costs and cost-effectiveness of pharmaceutical and non-pharmaceutical interventions aimed at reducing, monitoring and controlling ABR in patients. Articles published until 12 December 2023 were explored using EconLit, EMBASE and PubMed. We focused on critical or high-priority bacteria, as defined by the WHO, and intervention costs and incremental cost-effectiveness ratio (ICER). Following Preferred Reporting Items for Systematic review and Meta-Analysis guidelines, we extracted unit costs, ICERs and essential study information including country, intervention, bacteria-drug combination, discount rates, type of model and outcomes. Costs were reported in 2022 US dollars ($), adopting the healthcare system perspective. Country willingness-to-pay (WTP) thresholds from Woods et al 2016 guided cost-effectiveness assessments. We assessed the studies reporting checklist using Drummond¿s method. Results: Among 20.958 articles, 59 (32 pharmaceutical and 27 non-pharmaceutical interventions) met the inclusion criteria. Non-pharmaceutical interventions, such as hygiene measures, had unit costs as low as $1 per patient, contrasting with generally higher pharmaceutical intervention costs. Several studies found that linezolid-based treatments for methicillin-resistant Staphylococcus aureus were cost-effective compared with vancomycin (ICER up to $21¿488 per treatment success, all 16 studies¿ ICERs<WTP). Infection control measures such as hand hygiene and gown usage (ICER=$1160/QALY or $4949 per ABR case averted, all ICERs<WTP) and PCR or chromogenic agar screening for ABR detection were highly cost-effective (eg, ICER=$1206 and $1115 per life-year saved in Europe and the USA). Comparisons were hindered by within-study differences. Conclusion: Robust information on ABR ...
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