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Association of social isolation and loneliness with risk of incident hospital-treated infections: an analysis of data from the UK Biobank and Finnish Health and Social Support studies

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Τίτλος: Association of social isolation and loneliness with risk of incident hospital-treated infections: an analysis of data from the UK Biobank and Finnish Health and Social Support studies
Συγγραφείς: Elovainio, M, Komulainen, K, Sipilä, PN, Pulkki-Råback, L, Cachón Alonso, L, Pentti, J, Nyberg, ST, Suominen, S, Vahtera, J, Lipsanen, J, Batty, GD, Hakulinen, C, Kivimäki, M
Πηγή: The Lancet Public Health , 8 (2) e109-e118. (2023)
Στοιχεία εκδότη: Elsevier BV
Έτος έκδοσης: 2023
Συλλογή: University College London: UCL Discovery
Θεματικοί όροι: Male, Humans, Female, Loneliness, Finland, Biological Specimen Banks, Social Support, United Kingdom, Communicable Diseases
Περιγραφή: BACKGROUND: Although loneliness and social isolation have been linked to an increased risk of non-communicable diseases such as cardiovascular disease and dementia, their association with the risk of severe infection is uncertain. We aimed to examine the associations between loneliness and social isolation and the risk of hospital-treated infections using data from two independent cohort studies. METHODS: We assessed the association between loneliness and social isolation and incident hospital-treated infections using data for participants from the UK Biobank study aged 38–73 years at baseline and participants from the nationwide population-based Finnish Health and Social Support (HeSSup) study aged 20–54 years at baseline. For inclusion in the study, participants had to be linked to national health registries, have no history of hospital-treated infections at or before baseline, and have complete data on loneliness or social isolation. Participants with missing data on hospital-treated infections, loneliness, and social isolation were excluded from both cohorts. The outcome was defined as a hospital admission with a primary diagnosis of infection, ascertained via linkage to electronic health records. FINDINGS: After exclusion of 8·6 million participants for not responding or not providing appropriate consent, the UK Biobank cohort consisted of 456 905 participants (249 586 women and 207 319 men). 26 860 (6·2%) of 436 001 participants with available data were reported as being lonely and 40 428 (9·0%) of 448 114 participants with available data were socially isolated. During a median 8·9 years (IQR 8·0–9·6) of follow-up, 51 361 participants were admitted to hospital due to an infectious disease. After adjustment for age, sex, demographic and lifestyle factors, and morbidities, loneliness was associated with an increased risk of a hospital-treated infection (hazard ratio [HR] 1·12 [95% CI 1·07–1·16]), whereas social isolation was not (HR 1·01 [95% CI 0·97–1·04]). Of 64 797 individuals in the HeSSup cohort, 18 468 ...
Τύπος εγγράφου: article in journal/newspaper
Περιγραφή αρχείου: text
Γλώσσα: English
Relation: https://discovery.ucl.ac.uk/id/eprint/10166669/
Διαθεσιμότητα: https://discovery.ucl.ac.uk/id/eprint/10166669/2/Kivimaki_1-s2.0-S2468266722002535-main.pdf
https://discovery.ucl.ac.uk/id/eprint/10166669/
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  Data: Association of social isolation and loneliness with risk of incident hospital-treated infections: an analysis of data from the UK Biobank and Finnish Health and Social Support studies
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  Data: <searchLink fieldCode="AR" term="%22Elovainio%2C+M%22">Elovainio, M</searchLink><br /><searchLink fieldCode="AR" term="%22Komulainen%2C+K%22">Komulainen, K</searchLink><br /><searchLink fieldCode="AR" term="%22Sipilä%2C+PN%22">Sipilä, PN</searchLink><br /><searchLink fieldCode="AR" term="%22Pulkki-Råback%2C+L%22">Pulkki-Råback, L</searchLink><br /><searchLink fieldCode="AR" term="%22Cachón+Alonso%2C+L%22">Cachón Alonso, L</searchLink><br /><searchLink fieldCode="AR" term="%22Pentti%2C+J%22">Pentti, J</searchLink><br /><searchLink fieldCode="AR" term="%22Nyberg%2C+ST%22">Nyberg, ST</searchLink><br /><searchLink fieldCode="AR" term="%22Suominen%2C+S%22">Suominen, S</searchLink><br /><searchLink fieldCode="AR" term="%22Vahtera%2C+J%22">Vahtera, J</searchLink><br /><searchLink fieldCode="AR" term="%22Lipsanen%2C+J%22">Lipsanen, J</searchLink><br /><searchLink fieldCode="AR" term="%22Batty%2C+GD%22">Batty, GD</searchLink><br /><searchLink fieldCode="AR" term="%22Hakulinen%2C+C%22">Hakulinen, C</searchLink><br /><searchLink fieldCode="AR" term="%22Kivimäki%2C+M%22">Kivimäki, M</searchLink>
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  Data: The Lancet Public Health , 8 (2) e109-e118. (2023)
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  Data: Elsevier BV
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  Data: 2023
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  Data: University College London: UCL Discovery
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  Data: <searchLink fieldCode="DE" term="%22Male%22">Male</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Loneliness%22">Loneliness</searchLink><br /><searchLink fieldCode="DE" term="%22Finland%22">Finland</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+Specimen+Banks%22">Biological Specimen Banks</searchLink><br /><searchLink fieldCode="DE" term="%22Social+Support%22">Social Support</searchLink><br /><searchLink fieldCode="DE" term="%22United+Kingdom%22">United Kingdom</searchLink><br /><searchLink fieldCode="DE" term="%22Communicable+Diseases%22">Communicable Diseases</searchLink>
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  Data: BACKGROUND: Although loneliness and social isolation have been linked to an increased risk of non-communicable diseases such as cardiovascular disease and dementia, their association with the risk of severe infection is uncertain. We aimed to examine the associations between loneliness and social isolation and the risk of hospital-treated infections using data from two independent cohort studies. METHODS: We assessed the association between loneliness and social isolation and incident hospital-treated infections using data for participants from the UK Biobank study aged 38–73 years at baseline and participants from the nationwide population-based Finnish Health and Social Support (HeSSup) study aged 20–54 years at baseline. For inclusion in the study, participants had to be linked to national health registries, have no history of hospital-treated infections at or before baseline, and have complete data on loneliness or social isolation. Participants with missing data on hospital-treated infections, loneliness, and social isolation were excluded from both cohorts. The outcome was defined as a hospital admission with a primary diagnosis of infection, ascertained via linkage to electronic health records. FINDINGS: After exclusion of 8·6 million participants for not responding or not providing appropriate consent, the UK Biobank cohort consisted of 456 905 participants (249 586 women and 207 319 men). 26 860 (6·2%) of 436 001 participants with available data were reported as being lonely and 40 428 (9·0%) of 448 114 participants with available data were socially isolated. During a median 8·9 years (IQR 8·0–9·6) of follow-up, 51 361 participants were admitted to hospital due to an infectious disease. After adjustment for age, sex, demographic and lifestyle factors, and morbidities, loneliness was associated with an increased risk of a hospital-treated infection (hazard ratio [HR] 1·12 [95% CI 1·07–1·16]), whereas social isolation was not (HR 1·01 [95% CI 0·97–1·04]). Of 64 797 individuals in the HeSSup cohort, 18 468 ...
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