Academic Journal
Self-regulated and temporal control of a 'breathing' microgel mediated by enzymatic reaction
| Title: | Self-regulated and temporal control of a 'breathing' microgel mediated by enzymatic reaction |
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| Authors: | Che, H., Buddingh, B.C., van Hest, J.C.M. |
| Source: | Che, H, Buddingh, B C & van Hest, J C M 2017, 'Self-regulated and temporal control of a "breathing" microgel mediated by enzymatic reaction', Angewandte Chemie - International Edition, vol. 56, no. 41, 41, pp. 12581-12585. https://doi.org/10.1002/anie.201706716 |
| Publication Year: | 2017 |
| Subject Terms: | breathing microgels, enzyme catalysis, feedback mechanism, non-equilibrium processes, self-regulation, Biocatalysis, Fluorescence, Particle Size, Nylons/chemistry, Urease/chemistry, Enzymes, Immobilized/chemistry, Methacrylates/chemistry, Urea/chemistry, Gels/chemistry, Hydrogen-Ion Concentration |
| Description: | Naturally occurring systems have the ability to self-regulate, which plays a key role in their structural and functional adaptation. The autonomous behavior in living systems is biocatalytically controlled by the continuous consumption of energy to remain in a non-equilibrium condition. In this work, we show the construction of a self-regulated breathing microgel that uses chemical fuels to keep the system in the out-of-equilibrium state. The enzyme urease is utilized to program a feedback-induced pH change, which in turn tunes the size switch and fluorescence intensity of the microgel. A continuous supply of chemical fuels to the system allows the process to be reversible. This microgel with tunable autonomous properties provides insights into the design of artificial systems and dynamic soft materials. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0570-0833 1521-3773 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/28772021; info:eu-repo/semantics/altIdentifier/wos/000411810600028; info:eu-repo/semantics/altIdentifier/pissn/0570-0833; info:eu-repo/semantics/altIdentifier/eissn/1521-3773 |
| DOI: | 10.1002/anie.201706716 |
| Availability: | https://research.tue.nl/en/publications/6352e8e3-2fc5-4a87-a42d-e0b7fcb610f6 https://doi.org/10.1002/anie.201706716 https://pure.tue.nl/ws/files/79763571/cheself_2017.pdf https://www.scopus.com/pages/publications/85029916633 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.140C4A2 |
| Database: | BASE |
| ISSN: | 05700833 15213773 |
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| DOI: | 10.1002/anie.201706716 |