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Early-Life Adversity, CRF Dysregulation, and Vulnerability to Mood and Anxiety Disorders

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Τίτλος: Early-Life Adversity, CRF Dysregulation, and Vulnerability to Mood and Anxiety Disorders
Συγγραφείς: Charles B, Nemeroff CB
Πηγή: Psychopharmacology bulletin. 38(1)
Στοιχεία εκδότη: 2016.
Έτος έκδοσης: 2016
Θεματικοί όροι: 03 medical and health sciences, Depressive Disorder, Hypothalamo-Hypophyseal System, 0302 clinical medicine, Corticotropin-Releasing Hormone, Depression, Animals, Humans, Anxiety Disorders, Antidepressive Agents, 3. Good health
Περιγραφή: A large and growing literature suggests that traumatic experiences early in life increase the risk of mood and anxiety disorders in genetically predisposed persons. Findings from laboratory animal studies as well as studies of women with histories of early-life trauma demonstrate that long-lived alterations in the corticotropin-releasing factor (CRF) system and stress responses underlie this vulnerability. Women with histories of abuse plus current depression exhibit the greatest abnormalities in the hypothalamic-pituitary response to stress and may represent a unique cohort of patients. Studies in laboratory animals also suggest that persistent changes in the CRF system may be reversed by antidepressants or surrogate parenting, which underscores the urgent need for primary and secondary prevention studies in children who are living in adverse or dangerous environments. Psychopharmacology Bulletin. 2004;38(Suppl 1): 14-20.
Τύπος εγγράφου: Article
Γλώσσα: English
ISSN: 0048-5764
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/15278013
Αριθμός Καταχώρησης: edsair.pmid..........af7ad6d37abd845e2bcfb6da3d6cc1dc
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  Data: <searchLink fieldCode="DE" term="%2203+medical+and+health+sciences%22">03 medical and health sciences</searchLink><br /><searchLink fieldCode="DE" term="%22Depressive+Disorder%22">Depressive Disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Hypothalamo-Hypophyseal+System%22">Hypothalamo-Hypophyseal System</searchLink><br /><searchLink fieldCode="DE" term="%220302+clinical+medicine%22">0302 clinical medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Corticotropin-Releasing+Hormone%22">Corticotropin-Releasing Hormone</searchLink><br /><searchLink fieldCode="DE" term="%22Depression%22">Depression</searchLink><br /><searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+Disorders%22">Anxiety Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressive+Agents%22">Antidepressive Agents</searchLink><br /><searchLink fieldCode="DE" term="%223%2E+Good+health%22">3. Good health</searchLink>
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  Data: A large and growing literature suggests that traumatic experiences early in life increase the risk of mood and anxiety disorders in genetically predisposed persons. Findings from laboratory animal studies as well as studies of women with histories of early-life trauma demonstrate that long-lived alterations in the corticotropin-releasing factor (CRF) system and stress responses underlie this vulnerability. Women with histories of abuse plus current depression exhibit the greatest abnormalities in the hypothalamic-pituitary response to stress and may represent a unique cohort of patients. Studies in laboratory animals also suggest that persistent changes in the CRF system may be reversed by antidepressants or surrogate parenting, which underscores the urgent need for primary and secondary prevention studies in children who are living in adverse or dangerous environments. Psychopharmacology Bulletin. 2004;38(Suppl 1): 14-20.
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      – SubjectFull: Depressive Disorder
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      – SubjectFull: Hypothalamo-Hypophyseal System
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      – SubjectFull: Animals
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