Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Novel risk loci for COVID-19 hospitalization among admixed American populations |
| Συγγραφείς: |
Diz-de Almeida, Silvia, Cruz, Raquel, Luchessi, Andre D, Lorenzo-Salazar, José M, López de Heredia, Miguel, Quintela, Inés, González-Montelongo, Rafaela, Nogueira Silbiger, Vivian, Porras, Marta Sevilla, Tenorio Castaño, Jair Antonio, Nevado, Julián, Aguado, José María, Aguilar, Carlos, Aguilera-Albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, Arango, Celso, Arranz, María J, Artiga, Maria-Jesus, Baptista-Rosas, Raúl C, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F, Bezerra, Marcos A C, Boix-Palop, Lucía, Brion, María, Brugada, Ramón, Bustos, Matilde, Calderón, Enrique J, Carbonell, Cristina, Castano, Luis, Castelao, Jose E, Conde-Vicente, Rosa, Cordero-Lorenzana, M Lourdes, Cortes-Sanchez, Jose L, Corton, Marta, Darnaude, M Teresa, De Martino-Rodríguez, Alba, Del Campo-Pérez, Victor, Diaz de Bustamante, Aranzazu, Domínguez-Garrido, Elena, Eirós, Rocío, Fariñas, María Carmen, Fernandez-Nestosa, María J, Fernández-Robelo, Uxía, Fernandez-Rodriguez, Amanda, Fernández-Villa, Tania, Gago-Dominguez, Manuela, Gil-Fournier, Belén, Gómez-Arrue, Javier, González Álvarez, Beatriz, González Bernaldo de Quirós, Fernan, González-Neira, Anna, González-Peñas, Javier, Gutiérrez-Bautista, Juan F, Herrero, María José, Herrero-Gonzalez, Antonio, Jimenez-Sousa, Maria Angeles, Lattig, María Claudia, Liger Borja, Anabel, Lopez-Rodriguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martinez-Nieto, Oscar, Martinez-Lopez, Iciar, Martinez-Resendez, Michel F, Martinez-Perez, Angel, Mazzeu, Juliana F, Merayo Macías, Eleuterio, Minguez, Pablo, Moreno Cuerda, Victor, Oliveira, Silviene F, Ortega-Paino, Eva, Pompa-Mera, Ericka N, Parellada, Mara, Paz-Artal, Estela, Santos, Ney PC, Pérez-Matute, Patricia, Perez, Patricia, Pérez-Tomás, M Elena, Perucho, Teresa, Pinsach-Abuin, Mel·lina, Pita, Guillermo, Porras-Hurtado, Gloria L, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodriguez-Garcia, José A, Ruiz-Cabello, Francisco, Ruiz-Hornillos, Javier, Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Tamayo, Eduardo, Tamayo-Velasco, Álvaro, Taracido-Fernandez, Juan Carlos, Teper, Alejandro, Torres-Tobar, Lilian, Urioste, Miguel, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, de Rojas, Itziar, Ruiz, Agustín, Sánchez, Pascual, Real, Luis Miguel, SCOURGE Cohort Group, Guillén-Navarro, Encarna, Ayuso, Carmen, Parra, Esteban, Riancho, José A, Rojas-Martinez, Augusto, Flores, Carlos |
| Συνεισφορές: |
Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Banco Santander, Fundación La Caixa, Agencia Estatal de Investigación (España), Gobierno de Canarias (España), Fundación Canaria de Investigación Sanitaria, Xunta de Galicia (España), Fundación Amancio Ortega, Estrella de Levante, Colabora Mujer |
| Στοιχεία εκδότη: |
eLife Sciences Publications, 2024. |
| Έτος έκδοσης: |
2024 |
| Θεματικοί όροι: |
Male, SARS-CoV-2, COVID-19, SNP, Genomics, Middle Aged, Polymorphism, Single Nucleotide, Hospitalization, Latin America, Genetic Loci, Risk Factors, None, Genetics, GWAS, Humans, Female, Genetic Predisposition to Disease, Aged, Genome-Wide Association Study |
| Περιγραφή: |
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations ( and ). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in . Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research. |
| Τύπος εγγράφου: |
Article |
| Περιγραφή αρχείου: |
application/pdf; application/octet-stream |
| Γλώσσα: |
Spanish; Castilian |
| Σύνδεσμος πρόσβασης: |
https://hdl.handle.net/20.500.12105/26351 |
| Rights: |
CC BY |
| Αριθμός Καταχώρησης: |
edsair.od......4734..6538aa7ad4f34227bffc5770067968e5 |
| Βάση Δεδομένων: |
OpenAIRE |