Bibliographic Details
| Title: |
Novel risk loci for COVID-19 hospitalization among admixed American populations |
| Authors: |
Diz-de Almeida, Silvia, Cruz, Raquel, D Luchessi, Andre, M Lorenzo-salazar, José, López De Heredia, Miguel, Quintela, Inés, González-montelongo, Rafaela, Nogueira Silbiger, Vivian, Sevilla Porras, Marta, Antonio Tenorio Castaño, Jair, Nevado, Julian, María Aguado, Jose, Aguilar, Carlos, Aguilera-albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-bernabeu, Álvaro, Arana-arri, Eunate, Arango, Celso, J Arranz, María, Artiga, Maria-jesus, C Baptista-rosas, Raúl, Barreda- Sánchez, María, Belhassen-garcia, Moncef, F Bezerra, Joao, Ac Bezerra, Marcos, Boix-palop, Lucía, Brion, María, Brugada, Ramón, Bustos, Matilde, J Calderón, Enrique, Carbonell, Cristina, Castano, Luis, E Castelao, Jose, Conde-vicente, Rosa, Lourdes Cordero-lorenzana, M, L Cortes-sanchez, Jose, Corton, Marta, Teresa Darnaude, M, De Martino-rodríguez, Alba, Del Campo-pérez, Victor, Diaz De Bustamante, Aranzazu, Domínguez-garrido, Elena, Eirós, Rocío, Carmen Fariñas, María, J Fernandez-nestosa, María, Fernández-robelo, Uxía, Fernández-rodríguez, Amanda, Fernández-villa, Tania, Gago-dominguez, Manuela, Gil-fournier, Belén, Gómez-arrue, Javier, González Álvarez, Beatriz, Gonzalez Bernaldo De Quirós, Fernan, González-neira, Anna, González-peñas, Javier, F Gutiérrez-bautista, Juan, José Herrero, María, Herrero-gonzalez, Antonio, A Jimenez-sousa, María, Claudia Lattig, María, Liger Borja, Anabel, Lopez-rodriguez, Rosario, Mancebo, Esther, Martín-lópez, Caridad, Martín, Vicente, Martinez-nieto, Oscar, Martinez-lopez, Iciar, F Martinez-resendez, Michel, Martinez-perez, Angel, F Mazzeu, Juliana, Merayo Macías, Eleuterio, Minguez, Pablo, Moreno Cuerda, Victor, F Oliveira, Silviene, Ortega-paino, Eva, Parellada, Mara, Paz-artal, Estela, Pc Santos, Ney, Pérez-matute, Patricia, Perez, Patricia, Elena Pérez-tomás, M, Perucho, Teresa, Pinsach-abuin, Mellina, Pita, Guillermo, N Pompa-mera, Ericka, L Porras-hurtado, Gloria, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, R Fernandes, Marianne, Rodríguez-ruiz, Emilio, Rodriguez-artalejo, Fernando, A Rodriguez-garcia, José, Ruiz-cabello, Francisco, Ruiz-hornillos, Javier, Ryan, Pablo, Manuel Soria, José, Carlos Souto, Juan |
| Source: |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| Publisher Information: |
eLife Sciences Publications, Ltd, 2025. |
| Publication Year: |
2025 |
| Description: |
The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research. |
| Document Type: |
Article |
| File Description: |
application/pdf |
| Language: |
English |
| Access URL: |
https://hdl.handle.net/2445/222851 |
| Accession Number: |
edsair.od.......963..b6a06b43c21471c1f82e3b944d52ba8f |
| Database: |
OpenAIRE |