Bibliographic Details
| Title: |
Muscle strength recovery in patients with idiopathic inflammatory myopathy with different myositis-specific autoantibodies |
| Authors: |
Naoki Mugii, Yasuhito Hamaguchi, Fujiko Someya, Pleiades Tiharu Inaoka, Sho Horie, Natsumi Fushida, Tasuku Kitano, Ko Fujii, Jiro Nishio, Kyosuke Oishi, Takashi Matsushita |
| Source: |
Immunological Medicine, Pp 1-9 (2025) |
| Publisher Information: |
Informa UK Limited, 2025. |
| Publication Year: |
2025 |
| Subject Terms: |
idiopathic inflammatory myopathy, myositis-specific autoantibody, physical exercise, Hand held dynamometer, muscle strength recovery, Immunologic diseases. Allergy, RC581-607 |
| Description: |
This study aims to assess muscle strength recovery in patients with idiopathic inflammatory myopathy (IIM) with three myositis-specific autoantibodies (MSAs). Forty-eight IIM patients (19 with anti-TIF1-γ Ab, 21 with anti-ARS Ab, and 8 with anti-SRP Ab) were included. Physical exercise began one week after starting medication. Muscle strength was measured using a hand held dynamometer. CK levels, muscle strength recovery, manual muscle test 8 (MMT8), and the Barthel index (BI) scores were evaluated before and after treatment among patients with anti-TIF1-γ, anti-ARS or anti-SRP Abs. CK levels decreased after one week of medication, and physical exercise did not worsen muscle involvement. Patients with anti-TIF1-γ and anti-ARS Abs exhibited rapid muscle strength improvement, while those with anti-SRP Ab had slower recovery. MMT8 followed a similar trend. BI scores significantly improved in patients with anti-TIF1-γ and anti-ARS Abs. All eight patients with anti-SRP Ab achieved a BI score of 100 despite no significant changes due to high variability. Muscle strength improved significantly, even in patients with a BI score ≤ 60. Muscle strength was recovered regardless of their MSA profile, and physical exercise may be safe for restoring muscle strength. |
| Document Type: |
Article |
| Language: |
English |
| ISSN: |
2578-5826 |
| DOI: |
10.1080/25785826.2025.2537472 |
| Access URL: |
https://doaj.org/article/c750b9eb0eb4492a9af26e257ae5fe8b |
| Rights: |
CC BY |
| Accession Number: |
edsair.doi.dedup.....f8b6f06b16b5253ae2df654312e36b46 |
| Database: |
OpenAIRE |