Academic Journal
Age‐dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury
| Τίτλος: | Age‐dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury |
|---|---|
| Συγγραφείς: | Heather C. Bouchard, Delin Sun, Emily L. Dennis, Mary R. Newsome, Seth G. Disner, Jeremy Elman, Annelise Silva, Carmen Velez, Andrei Irimia, Nicholas D. Davenport, Scott R. Sponheim, Carol E. Franz, William S. Kremen, Michael J. Coleman, M. Wright Williams, Elbert Geuze, Inga K. Koerte, Martha E. Shenton, Maheen M. Adamson, Raul Coimbra, Gerald Grant, Lori Shutter, Mark S. George, Ross D. Zafonte, Thomas W. McAllister, Murray B. Stein, Paul M. Thompson, Elisabeth A. Wilde, David F. Tate, Aristeidis Sotiras, Rajendra A. Morey |
| Συνεισφορές: | MGGZ, Brain, Cardiologie, Psychiatry, School of Medicine |
| Πηγή: | Hum Brain Mapp Human Brain Mapping, vol 43, iss 8 |
| Στοιχεία εκδότη: | Wiley, 2022. |
| Έτος έκδοσης: | 2022 |
| Θεματικοί όροι: | Other Analytical, Traumatic, Psychiatry and Psychology, Sports Sciences, Nervous System, Nonnegative matrix factorization, diffusion MRI, Stress Disorders, Post-Traumatic, Traumatic brain injury, 0302 clinical medicine, Brain Injuries, Traumatic, Medicine and Health Sciences, Psychology, 2.1 Biological and endogenous factors, Cognitive and computational psychology, military, Research Articles, Stress Disorders, Veterans, Diagnostic and Therapeutic Techniques and Equipment, Neuroscience and Neurobiology, Radiological and Ultrasound Technology, White Matter/diagnostic imaging, Clinical and Health Psychology, traumatic brain injury, ENIGMA, Life Sciences, nonnegative matrix factorization, Brain, Experimental Psychology, Other Neuroscience and Neurobiology, White Matter, Rehabilitation and Therapy, Military Personnel, Neurology, Radiology Nuclear Medicine and imaging, Cognitive Sciences, Anatomy, Physical Injury - Accidents and Adverse Effects, Clinical Neurology, Traumatic Brain Injury (TBI), Brain Concussion/diagnostic imaging, Brain Injuries/etiology, Diffusion MRI, Behavior and Behavior Mechanisms, 03 medical and health sciences, mTBI, Military, Journal Article, Humans, Traumatic Head and Spine Injury, Brain Concussion, Brain Injuries, Traumatic/complications, Neurosciences, Analytical, Brain/diagnostic imaging, Other Psychiatry and Psychology, Brain Disorders, Stress Disorders, Post-Traumatic/complications, Brain Injuries, Multivariate Analysis, Post-Traumatic, Biological psychology, Meta-Analysis |
| Περιγραφή: | Mild Traumatic brain injury (mTBI) is a signature wound in military personnel, and repetitive mTBI has been linked to age‐related neurogenerative disorders that affect white matter (WM) in the brain. However, findings of injury to specific WM tracts have been variable and inconsistent. This may be due to the heterogeneity of mechanisms, etiology, and comorbid disorders related to mTBI. Non‐negative matrix factorization (NMF) is a data‐driven approach that detects covarying patterns (components) within high‐dimensional data. We applied NMF to diffusion imaging data from military Veterans with and without a self‐reported TBI history. NMF identified 12 independent components derived from fractional anisotropy (FA) in a large dataset (n = 1,475) gathered through the ENIGMA (Enhancing Neuroimaging Genetics through Meta‐Analysis) Military Brain Injury working group. Regressions were used to examine TBI‐ and mTBI‐related associations in NMF‐derived components while adjusting for age, sex, post‐traumatic stress disorder, depression, and data acquisition site/scanner. We found significantly stronger age‐dependent effects of lower FA in Veterans with TBI than Veterans without in four components (q |
| Τύπος εγγράφου: | Article Other literature type |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.25811 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/35289463 https://dspace.library.uu.nl/handle/1874/446058 https://escholarship.org/uc/item/7xf3m37b https://escholarship.org/content/qt7xf3m37b/qt7xf3m37b.pdf |
| Rights: | CC BY NC |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....e6a6b6f3d56753cee97267d9f0e7777c |
| Βάση Δεδομένων: | OpenAIRE |
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