Academic Journal
Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism
| Title: | Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism |
|---|---|
| Authors: | Byoung Seok Ye, Seong Ho Jeong, Sung Woo Kang, Young H. Sohn, Alzheimer’s Disease Neuroimaging Initiative, Min Cheol Park, Phil Hyu Lee, Kyoungwon Baik, Jin Ho Jung, Younggun Lee |
| Contributors: | Young-Gun Lee, Mincheol Park, Seong Ho Jeong, Sung Woo Kang, Kyoungwon Baik, Jin Ho Jung, Phil Hyu Lee, Young Ho Sohn, Byoung Seok Ye, Sohn, Young Ho |
| Source: | Neurobiology of Aging. 106:223-231 |
| Publisher Information: | Elsevier BV, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Male, 0301 basic medicine, Heterozygote, Genotype, Brain / diagnostic imaging, Apolipoprotein E4, Alzheimer Disease / prevention & control, Antioxidants, Cognitive Dysfunction / prevention & control, Brain metabolism, 03 medical and health sciences, Serum uric acid, Cognition, 0302 clinical medicine, Alzheimer Disease, 80 and over, Cognitive Dysfunction / psychology, Humans, Cognitive Dysfunction, Uric Acid / blood, Aged, Aged, 80 and over, Sex Characteristics, Alzheimer Disease / metabolism, Brain, Brain / metabolism, Alzheimer's disease, Uric Acid, 3. Good health, Alzheimer Disease / genetics, Cognitive Dysfunction / metabolism, Positron-Emission Tomography, Cognitive Dysfunction / genetics, Disease Progression, Alzheimer Disease / psychology, Apolipoprotein E4 / genetics, Female |
| Description: | Serum uric acid, a natural antioxidant, may have a protective effect on the progression of Alzheimer's disease (AD). To investigate the effect of serum uric acid on longitudinal cognitive and brain metabolic changes, we utilized data on baseline serum uric acid levels, APOE genotyping, and longitudinal cognitive scores from the Alzheimer's Disease Neuroimaging Initiative for 1,343 participants with normal cognition (NC), mild cognitive impairment (MCI), or dementia. In 979 participants, brain metabolism was measured using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images. Higher serum uric acid levels exhibited a detrimental effect on NC, whereas a protective trend was observed in individuals with cognitive impairment. Interestingly, higher uric acid levels were associated with a slower decline in cognitive scores and brain metabolism in females with MCI, and this effect was found in APOE4 carriers, but not in non-carriers. Longitudinal AD-like patterns of brain metabolism on FDG-PET images also appeared to mediate the effects of baseline uric acid levels on longitudinal cognitive decline. In summary, higher serum uric acid may interact with APOE4 to alleviate longitudinal metabolic changes and cognitive decline in female MCI patients. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2021.05.003 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/34311431 https://pubmed.ncbi.nlm.nih.gov/34311431/ https://www.sciencedirect.com/science/article/pii/S0197458021001573 |
| Rights: | Elsevier TDM CC BY NC ND |
| Accession Number: | edsair.doi.dedup.....d2f0c8965021d6cb6f193cfed2565f11 |
| Database: | OpenAIRE |
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