Academic Journal
The RNA Atlas expands the catalog of human non-coding RNAs
| Τίτλος: | The RNA Atlas expands the catalog of human non-coding RNAs |
|---|---|
| Συγγραφείς: | Justine Nuytens, Pavel Sumazin, Gary P. Schroth, Govardhan Anande, Marc R. Wilkins, Tom Taghon, Karim Vermaelen, Katrien Vanderheyden, Ting-Wen Chen, Francisco Avila Cobos, Yvan Saeys, Robrecht Cannoodt, Marieke Vromman, Nandan P. Deshpande, Jan Koster, Nele Nijs, Lucia Lorenzi, Scott Kuersten, Pieter Mestdagh, Jørgen Kjems, Jo Vandesompele, Aidan P. Tay, Tim De Meyer, Steve Lefever, Jasper Anckaert, Eric James de Bony, Ken R. Bracke, Thomas B. Hansen, Fien Gysens, Pieter-Jan Volders, Wim Trypsteen, Katleen De Preter, Tine Goovaerts, Ashwin Unnikrishnan, Hua-Sheng Chiu, Stephen M. Gross |
| Πηγή: | Lorenzi, L, Chiu, H S, Avila Cobos, F, Gross, S, Volders, P J, Cannoodt, R, Nuytens, J, Vanderheyden, K, Anckaert, J, Lefever, S, Tay, A P, de Bony, E J, Trypsteen, W, Gysens, F, Vromman, M, Goovaerts, T, Hansen, T B, Kuersten, S, Nijs, N, Taghon, T, Vermaelen, K, Bracke, K R, Saeys, Y, De Meyer, T, Deshpande, N P, Anande, G, Chen, T W, Wilkins, M R, Unnikrishnan, A, De Preter, K, Kjems, J, Koster, J, Schroth, G P, Vandesompele, J, Sumazin, P & Mestdagh, P 2021, 'The RNA Atlas expands the catalog of human non-coding RNAs', Nature Biotechnology, vol. 39, no. 11, pp. 1453-1465. https://doi.org/10.1038/s41587-021-00936-1 Nature Biotechnology |
| Publication Status: | Preprint |
| Στοιχεία εκδότη: | Springer Science and Business Media LLC, 2021. |
| Έτος έκδοσης: | 2021 |
| Θεματικοί όροι: | RNA, Untranslated, Human Genome, Messenger, Untranslated, 3105 Genetics, 3. Good health, 3102 Bioinformatics and Computational Biology, anzsrc-for: 3105 Genetics, MicroRNAs, Genetics, 2.1 Biological and endogenous factors, RNA, Humans, Long Noncoding, RNA, Long Noncoding, Generic health relevance, RNA, Messenger, anzsrc-for: 31 Biological Sciences, anzsrc-for: 3102 Bioinformatics and Computational Biology, Transcriptome, 31 Biological Sciences, Biotechnology |
| Περιγραφή: | Existing compendia of non-coding RNA (ncRNA) are incomplete, in part because they are derived almost exclusively from small and polyadenylated RNAs. Here we present a more comprehensive atlas of the human transcriptome, which includes small and polyA RNA as well as total RNA from 300 human tissues and cell lines. We report thousands of previously uncharacterized RNAs, increasing the number of documented ncRNAs by approximately 8%. To infer functional regulation by known and newly characterized ncRNAs, we exploited pre-mRNA abundance estimates from total RNA sequencing, revealing 316 microRNAs and 3,310 long non-coding RNAs with multiple lines of evidence for roles in regulating protein-coding genes and pathways. Our study both refines and expands the current catalog of human ncRNAs and their regulatory interactions. All data, analyses and results are available for download and interrogation in the R2 web portal, serving as a basis for future exploration of RNA biology and function. |
| Τύπος εγγράφου: | Article |
| Γλώσσα: | English |
| ISSN: | 1546-1696 1087-0156 |
| DOI: | 10.1038/s41587-021-00936-1 |
| DOI: | 10.5281/zenodo.5909808 |
| DOI: | 10.5281/zenodo.5909807 |
| Σύνδεσμος πρόσβασης: | https://zenodo.org/record/5909808/files/s41587-021-00936-1.pdf https://pubmed.ncbi.nlm.nih.gov/34140680 https://www.scilit.net/article/e8f72da1ec95db8d06ba219b76929e96?action=show-references https://www.nature.com/articles/s41587-021-00936-1.pdf https://www.narcis.nl/publication/RecordID/oai%3Apure.amc.nl%3Apublications%2F41219244-6b7d-4a10-9920-3776fc670878 https://scholar.nycu.edu.tw/zh/publications/the-rna-atlas-expands-the-catalog-of-human-non-coding-rnas https://biblio.ugent.be/publication/8715077 https://europepmc.org/article/MED/34140680 |
| Rights: | Springer TDM CC BY CC BY NC ND |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....c28c0dc79d11cbb4d61d9ccee5d6f076 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 15461696 10870156 |
|---|---|
| DOI: | 10.1038/s41587-021-00936-1 |