Academic Journal
Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger: A NOTION-2 substudy
| Τίτλος: | Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger: A NOTION-2 substudy |
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| Συγγραφείς: | Troels Højsgaard Jørgensen, Hans Gustav Hørsted Thyregod, Mikko Savontaus, Öjvind Bleie, Evald H Christiansen, Matti Niemela, Oskar Angerås, Ingibjörg J. Gudmundsdóttir, Mika Laine, Andreas Rück, Bernard Prendergast, Martin Leon, Lars Søndergaard, Ole De Backer |
| Πηγή: | Jørgensen, T H, Thyregod, H G H, Savontaus, M, Bleie, Ö, Christiansen, E H, Niemela, M, Angerås, O, Gudmundsdóttir, I J, Laine, M, Rück, A, Prendergast, B, Leon, M, Søndergaard, L, De Backer, O & NOTION-2 investigators 2025, ' Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger : A NOTION-2 substudy ', American Heart Journal, vol. 284, pp. 67-70 . https://doi.org/10.1016/j.ahj.2025.02.003 Christiansen, E H & NOTION-2 investigators 2025, 'Transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis aged 70 years or younger : A NOTION-2 substudy', American Heart Journal, vol. 284, pp. 67-70. https://doi.org/10.1016/j.ahj.2025.02.003 |
| Στοιχεία εκδότη: | Elsevier BV, 2025. |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | Transcatheter Aortic Valve Replacement/methods, Stroke/etiology, Postoperative Complications/epidemiology, Male, Heart Valve Prosthesis Implantation, Heart Valve Prosthesis Implantation/methods, Age Factors, Heart Valve Diseases, Bicuspid Aortic Valve Disease/surgery, Aortic Valve Stenosis, Middle Aged, Severity of Illness Index, Transcatheter Aortic Valve Replacement, Postoperative Complications, Treatment Outcome, Bicuspid Aortic Valve Disease, Risk Factors, Aortic Valve, Humans, Female, Aortic Valve Stenosis/surgery, Aortic Valve/surgery, Aged |
| Περιγραφή: | This NOTION-2 sub-study revealed distinct outcomes for transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in low surgical risk patients aged ≤ 70 years with a tricuspid or bicuspid aortic valve stenosis (AS). One year after intervention, the risk of death, stroke or rehospitalization in patients with tricuspid AS was similar after TAVR when compared to SAVR (absolute risk difference: -2.0%; 95% confidence interval (CI): -11.8% to 7.7%) Conversely, in patients with bicuspid AS, TAVR was associated with a significantly higher risk of adverse outcomes (absolute risk difference: 13.8%; 95% CI: 1.2% to 26.3%). These analyses are exploratory, but highlight the importance of tailoring the intervention to the patient's clinical risk profile, life expectancy, native aortic valve morphology and the anticipated risks associated with TAVR or SAVR. |
| Τύπος εγγράφου: | Article |
| Περιγραφή αρχείου: | application/pdf |
| Γλώσσα: | English |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/j.ahj.2025.02.003 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/39952377 https://curis.ku.dk/ws/files/431398649/1_s2.0_S0002870325000341_main.pdf http://www.scopus.com/inward/record.url?scp=85219260086&partnerID=8YFLogxK https://doi.org/10.1016/j.ahj.2025.02.003 https://pure.au.dk/portal/en/publications/0c636d63-6931-47f2-a9f4-e7e5f5b9cea1 |
| Rights: | CC BY |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....c0d91e2e78a5d24dae2ff8146aca3a96 |
| Βάση Δεδομένων: | OpenAIRE |
| ISSN: | 00028703 |
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| DOI: | 10.1016/j.ahj.2025.02.003 |