Academic Journal
Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer’s Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study
| Title: | Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer’s Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study |
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| Authors: | Babiloni, Claudio, Noce, Giuseppe, Ferri, Raffaele, Lizio, Roberta, Lopez, Susanna, Lorenzo, Ivan, Tucci, Federico, Soricelli, Andrea, Zurrón, Montserrat, Díaz, Fernando, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Buttinelli, Carla, Giubilei, Franco, Cipollini, Virginia, Marizzoni, Moira, Güntekin, Bahar, Yıldırım, Ebru, Hanoğlu, Lutfu, Yener, Görsev, Gündüz, Duygu Hünerli, Onorati, Paolo, Stocchi, Fabrizio, Vacca, Laura, Maestú, Fernando, Frisoni, Giovanni B, Del Percio, Claudio |
| Source: | Cerebral Cortex. 32:2197-2215 |
| Publisher Information: | Oxford University Press (OUP), 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Male, Mild cognitive impairment due to Alzheimer's disease (ADMCI), Rest, Rest / physiology, Resting state electroencephalographic (rsEEG) rhythms, 618.97, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Alpha Rhythm / physiology, Exact low-resolution brain electromagnetic source tomography (eLORETA), Cognitive Dysfunction / psychology, Humans, Cognitive Dysfunction, Electroencephalography / methods, Aged, Retrospective Studies, Cerebral Cortex, exact low-resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer's disease (ADMCI), resting state electroencephalographic (rsEEG) rhythms, sex, Alzheimer Disease / psychology, Electroencephalography, Exact Low-Resolution Brain Electromagnetic Source Tomography (eLORETA), Alpha Rhythm, Mild Cognitive Impairment due to Alzheimer's Disease (ADMCI), Resting State Electroencephalographic (rsEEG) Rhythms, Sex, Female |
| Description: | In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer’s disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14–30 Hz) and gamma (30–40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (Aβ42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhab348 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/34613369 https://www.ncbi.nlm.nih.gov/pubmed/34613369 http://academic.oup.com/cercor/advance-article-pdf/doi/10.1093/cercor/bhab348/40513513/bhab348.pdf https://archive-ouverte.unige.ch/unige:171557 https://doi.org/10.1093/cercor/bhab348 https://hdl.handle.net/11367/99265 https://doi.org/10.1093/cercor/bhab348 https://hdl.handle.net/11567/1060814 https://doi.org/10.1093/cercor/bhab348 |
| Rights: | OUP Standard Publication Reuse |
| Accession Number: | edsair.doi.dedup.....c086d5c42627603ce7fbf7af7fc0f7f5 |
| Database: | OpenAIRE |
| ISSN: | 14602199 10473211 |
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| DOI: | 10.1093/cercor/bhab348 |