Academic Journal
Treatment‐Free Remission Outcomes in a BCR::ABL1 Digital PCR Selected Clinical Cohort of CML Patients: :ABL1 Digital PCR Selected Clinical Cohort of CML Patients
| Τίτλος: | Treatment‐Free Remission Outcomes in a BCR::ABL1 Digital PCR Selected Clinical Cohort of CML Patients: :ABL1 Digital PCR Selected Clinical Cohort of CML Patients |
|---|---|
| Συγγραφείς: | Kockerols, C., Valk, P. J. M., Hogenbirk, P., Geelen, I., Blijlevens, N. M. A., Janssen, J. J. W. M., Hoogendoorn, M., Kersting, S., Klein, S. K., Daenen, L. G. M., Donker, M., te Boekhorst, P. A. W., Jie, K. -S. G., Corsten, M., Cruijsen, M. J., Levenga, H., Smit, W. M., Levin, M. D., de Jongh, E., de Jonge, S., Vlot, A. J., Durian, M. F., Zwaginga, J. J., Mohlmann, M., Wustman, T. J., Blommers, R., Cornelissen, J. J., Westerweel, P. E., Bilgin, Y., Broers, A. E. C., Brouwer, R., Castelijn, D. A. R., de Graaf, A. N., Demandt, A. M. P., Droogendijk, J., de Weerdt, E. C., van Kampen, R., Libourel, E., Ludwig, I., Oosterveld, M., Oostvogels, R., Oudhoff, J. P., van Rhenen, A., Stevens, W., Swart-Heikens, J., te Raa, D., van der Klift, M., van Lammeren, D., van Rijn, R., van Rooijen, C., Verpoorte, I. P. G., Willemsen, D., Wouters, B. J., Ypma, P. F. |
| Πηγή: | Eur J Haematol European Journal of Haematology, 114, 5, pp. 900-907 |
| Στοιχεία εκδότη: | Wiley, 2025. |
| Έτος έκδοσης: | 2025 |
| Θεματικοί όροι: | Male, Adult, treatment-free remission, Leukemia, Protein Kinase Inhibitors/therapeutic use, Polymerase Chain Reaction/methods, Remission Induction, bcr-abl/genetics, Fusion Proteins, Middle Aged, BCR-ABL Positive/genetics, Young Adult, Treatment Outcome, chronic myeloid leukemia, Humans, BCR::ABL1 digital PCR, Original Article, Female, tyrosine kinase inhibitor treatment discontinuation, Chronic, Haematology - Radboud University Medical Center, Myelogenous, Aged |
| Περιγραφή: | Approximately 40%–60% of patients reaching a stable deep molecular response during TKI treatment will maintain a state of remission after TKI discontinuation, denoted as treatment‐free remission (TFR). Depth of molecular response assessed by BCR::ABL1 digital PCR prior to TKI discontinuation has demonstrated its significance as a reliable predictive parameter for TFR. A clinically applicable prediction cutoff of 0.0023%IS has been established and externally validated. In this study, BCR::ABL1 digital PCR, as most sensitive and stable assay of its kind, was investigated as a TFR prediction tool in the Netherlands, and evaluated for its predictive value to stop TKI treatment below the aforementioned cutoff. The primary endpoint of molecular recurrence (MolR, BCR::ABL1 > 0.1%IS) at 12 months was prospectively assessed. Overall, 67 discontinued patients below the set BCR::ABL1 digital PCR cutoff were included. The overall MolR probability was 50% (95% CI, 36%–62%). In 38 patients treated for more than 6 years as commonly recommended as desirable treatment duration before TFR attempt, the MolR probability dropped to 36% (95% CI, 18%–50%). Patients attempting an early TKI discontinuation (treated for less than 6 years) had a high MolR probability of 76% (95% CI, 65%–89%). BCR::ABL1 digital PCR was successfully used in Dutch clinical practice. Our study indicates that in patients with a low BCR::ABL1 digital PCR result, a total TKI treatment duration of six or more years remains associated with a lower MolR rate and should generally be pursued. In patients treated for more than 6 years, BCR::ABL1 digital PCR was capable to identify stop candidates with a higher probability of TFR success. |
| Τύπος εγγράφου: | Article Other literature type |
| Γλώσσα: | English |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/ejh.14368 |
| Σύνδεσμος πρόσβασης: | https://pubmed.ncbi.nlm.nih.gov/39957332 https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/319059 https://doi.org/10.1111/ejh.14368 https://pure.eur.nl/en/publications/44e720bf-72de-4f82-bda8-c448ba51be25 https://doi.org/10.1111/ejh.14368 https://repository.ubn.ru.nl//bitstream/handle/2066/319059/319059.pdf https://hdl.handle.net/2066/319059 |
| Rights: | CC BY NC |
| Αριθμός Καταχώρησης: | edsair.doi.dedup.....c080e7b51af4d83e731e6862441b212a |
| Βάση Δεδομένων: | OpenAIRE |
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