Academic Journal
Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals: a sham-controlled study in healthy individuals
| Title: | Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals: a sham-controlled study in healthy individuals |
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| Authors: | Stefanie De Smet, Isabell Int-Veen, Gert Vanhollebeke, Matias M. Pulopulos, Beatrix Barth, Sarah Pasche, Chris Baeken, Hans-Christoph Nuerk, Christian Plewnia, Vanessa Nieratschker, Andreas Jochen Fallgatter, Ann-Christine Ehlis, Marie-Anne Vanderhasselt, David Rosenbaum |
| Contributors: | Neuroprotection & Neuromodulation, Clinical sciences, Brain, Body and Cognition, Psychiatry, Faculty of Psychology and Educational Sciences |
| Source: | CLINICAL NEUROPHYSIOLOGY |
| Publisher Information: | Elsevier BV, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Adult, TRANSCRANIAL MAGNETIC STIMULATION, SYMPTOMS, Rumination, Cognitive/physiology, Trier Social Stress Test, Hydrocortisone, Adolescent, DORSOLATERAL PREFRONTAL CORTEX, PERSEVERATIVE COGNITION, Prefrontal Cortex, HF-RTMS SESSION, Hydrocortisone/metabolism, Prefrontal Cortex (PFC), Cortisol, Transcranial Magnetic Stimulation/methods, ACTIVATION, Stimulation (rTMS), Young Adult, Dorsolateral Prefrontal Cortex, Heart Rate, Rumination, Medicine and Health Sciences, Humans, Repetitive Transcranial Magnetic Stimulation (rTMS), Theta Rhythm, Saliva, DEPRESSIVE RUMINATION, Theta Rhythm/physiology, CORTISOL, Dorsolateral Prefrontal Cortex/physiology, Saliva/chemistry, Stress, Psychological/physiopathology, Theta Burst Stimulation (TBS), Transcranial Magnetic Stimulation, Healthy Volunteers, VARIABILITY, Rumination, Cognitive, Prefrontal Cortex/physiology, young adult, Female, Heart Rate/physiology, Stress, Psychological, Repetitive Transcranial Magnetic, RESPONSES, Psychophysiology |
| Description: | Previous studies suggest that theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising approach to modulate stress-reactive rumination and the associated psychophysiological stress response. Crucially, individuals showing higher levels of trait rumination might benefit more from prefrontal stimulation.In this sham-controlled study, 127 healthy individuals, with varying ruminative tendencies, received a single-session of intermittent TBS (iTBS), continuous TBS (cTBS) or sham TBS (sTBS) over the left DLPFC before being confronted with a Trier Social Stress Test.Results showed significant TBS effects on salivary cortisol as a function of trait rumination. cTBS, as compared to sTBS and iTBS, resulted in an attenuated stress-induced cortisol response in high compared to low trait ruminators. Although independent of trait rumination levels, cTBS showed positive effects on stress-related changes in mood and, both cTBS and iTBS (versus sham) presented an enhanced heart rate recovery following the stressor. We found no evidence for (trait rumination-dependent) TBS effects on stress-reactive rumination, negative affect, subjective stress or heart rate variability.cTBS shows beneficial effects on certain measures of stress, especially in high trait ruminators.These findings highlight the importance of accounting for individual differences when examining TBS effects. |
| Document Type: | Article |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2024.03.016 |
| DOI: | 10.15496/publikation-102515 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38556367 https://research.tue.nl/en/publications/b1d9749a-3539-47d5-98d1-04038d53f6f1 https://doi.org/10.1016/j.clinph.2024.03.016 https://cris.maastrichtuniversity.nl/en/publications/60947598-5f1f-431f-820a-42c4fc1649de https://doi.org/10.1016/j.clinph.2024.03.016 https://biblio.vub.ac.be/vubir/(910c804b-fca6-4e05-865f-49ae722129e1).html http://hdl.handle.net/1854/LU-01HRRXMYRN8Z58WH3067QTZSP0 http://doi.org/10.1016/j.clinph.2024.03.016 https://biblio.ugent.be/publication/01HRRXMYRN8Z58WH3067QTZSP0 https://biblio.ugent.be/publication/01HRRXMYRN8Z58WH3067QTZSP0/file/01HV0ZZWG3KY8D0DKS6P05NP9K |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....c057ececfc454095a58a7a24eeffd39e |
| Database: | OpenAIRE |
| ISSN: | 13882457 |
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| DOI: | 10.1016/j.clinph.2024.03.016 |