Academic Journal
The use of serum methotrexate level as an assessment of biochemical drug adherence in psoriasis
| Title: | The use of serum methotrexate level as an assessment of biochemical drug adherence in psoriasis |
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| Authors: | Amelle G Ra, Zoe Littlewood, Anne Barton, Brian Keevil, Malcolm McTaggart, Richard B Warren, James Bluett |
| Source: | Ra, A G, Littlewood, Z, Barton, A, Keevil, B, McTaggart, M, Warren, R B & Bluett, J 2024, 'The use of serum methotrexate level as an assessment of biochemical drug adherence in psoriasis', The British journal of dermatology, vol. 190, no. 6, pp. 927-929. https://doi.org/10.1093/bjd/ljae096 |
| Publisher Information: | Oxford University Press (OUP), 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Adult, Assessment of Medication Adherence, Middle Aged, 3. Good health, 03 medical and health sciences, Methotrexate/blood, Methotrexate, 0302 clinical medicine, Psoriasis/drug therapy, Medication Adherence/statistics & numerical data, Humans, Psoriasis, Female, Dermatologic Agents, Dermatologic Agents/therapeutic use, Aged |
| Description: | Psoriasis is a common inflammatory skin condition affecting approximately 2–3% of people worldwide. Methotrexate (MTX) is a cheap and effective drug that is often recommended as the first-choice systemic agent for psoriasis. Around 40–50% of patients achieve a good response; however, mechanisms of nonresponse are poorly understood. It is not known whether biochemical MTX adherence in patients with psoriasis is suboptimal and requires intervention. Our aim was to audit biochemical MTX adherence using a sensitive liquid chromatography–tandem mass spectrometry in patients prescribed oral MTX for the treatment of psoriasis at our tertiary dermatology centre. Ethical approval for this audit was not required as confirmed by the Health Research Authority. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1093/bjd/ljae096 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38454565 https://research.manchester.ac.uk/en/publications/e13b5d43-c10f-46fd-955e-cdc020469a7f https://doi.org/10.1093/bjd/ljae096 https://research.manchester.ac.uk/en/publications/e13b5d43-c10f-46fd-955e-cdc020469a7f http://www.scopus.com/inward/record.url?scp=85193561273&partnerID=8YFLogxK https://doi.org/10.1093/bjd/ljae096 |
| Rights: | OUP Standard Publication Reuse |
| Accession Number: | edsair.doi.dedup.....a96d75502896d6f0aacdb123dec1cf1a |
| Database: | OpenAIRE |
| ISSN: | 13652133 00070963 |
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| DOI: | 10.1093/bjd/ljae096 |