Academic Journal
Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study
| Title: | Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study |
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| Authors: | Junker, Daniela, Wu, Mingming, Reik, Anna, Raspe, Johannes, Rupp, Selina, Han, Jessie, Näbauer, Stella M, Wiechert, Meike, Somasundaram, Arun, Burian, Egon, Waschulzik, Birgit, Makowski, Marcus R, Hauner, Hans, Holzapfel, Christina, Karampinos, Dimitrios C |
| Contributors: | University of Zurich, Junker, Daniela |
| Source: | Int J Obes (Lond) |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Adult, 0301 basic medicine, 10042 Clinic for Diagnostic and Interventional Radiology, Weight Loss/physiology [MeSH], 692/699/2743/393, Female [MeSH], 59/57, 692/699/1702/393, Adult [MeSH], Humans [MeSH], Prospective Studies [MeSH], Middle Aged [MeSH], Obesity/diet therapy [MeSH], 692/698, Adipose Tissue/pathology [MeSH], Body Mass Index [MeSH], Article, Intra-Abdominal Fat/diagnostic imaging [MeSH], Male [MeSH], Subcutaneous Fat/diagnostic imaging [MeSH], 692/308, Caloric Restriction/methods [MeSH], Magnetic Resonance Imaging/methods [MeSH], article, Subcutaneous Fat, 610 Medicine & health, 2701 Medicine (miscellaneous), Middle Aged, Intra-Abdominal Fat, Magnetic Resonance Imaging, ddc, Body Mass Index, 2712 Endocrinology, Diabetes and Metabolism, 03 medical and health sciences, 0302 clinical medicine, Adipose Tissue, Weight Loss, 2916 Nutrition and Dietetics, Humans, Female, Obesity, Prospective Studies, Caloric Restriction |
| Description: | Background/Objectives Weight loss outcomes vary individually. Magnetic resonance imaging (MRI)-based evaluation of adipose tissue (AT) might help to identify AT characteristics that predict AT loss. This study aimed to assess the impact of an 8-week low-calorie diet (LCD) on different AT depots and to identify predictors of short-term AT loss using MRI in adults with obesity. Methods Eighty-one adults with obesity (mean BMI 34.08 ± 2.75 kg/m², mean age 46.3 ± 10.97 years, 49 females) prospectively underwent baseline MRI (liver dome to femoral head) and anthropometric measurements (BMI, waist-to-hip-ratio, body fat), followed by a post-LCD-examination. Visceral and subcutaneous AT (VAT and SAT) volumes and AT fat fraction were extracted from the MRI data. Apparent lipid volumes based on MRI were calculated as approximation for the lipid contained in the AT. SAT and VAT volumes were subdivided into equidistant thirds along the craniocaudal axis and normalized by length of the segmentation. T-tests compared baseline and follow-up measurements and sex differences. Effect sizes on subdivided AT volumes were compared. Spearman Rank correlation explored associations between baseline parameters and AT loss. Multiple regression analysis identified baseline predictors for AT loss. Results Following the LCD, participants exhibited significant weight loss (11.61 ± 3.07 kg, p p p p Conclusions The LCD primarily reduces lower abdominopelvic SAT and VAT. Furthermore, lower abdominopelvic SAT volume was detected as a potential predictor for short-term AT loss in persons with obesity. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf; ZORA276152.pdf - application/pdf |
| Language: | English |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/s41366-024-01568-6 |
| DOI: | 10.5167/uzh-276152 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38926461 https://repository.publisso.de/resource/frl:6503746 https://mediatum.ub.tum.de/1770233 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....93c51c6ee48d57c73494aab9d655cd37 |
| Database: | OpenAIRE |
| ISSN: | 14765497 03070565 |
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| DOI: | 10.1038/s41366-024-01568-6 |